Stem cell therapeutics is a powerful means to heal the human body. However, instead of cells, we use the molecules released from stem cells. Why? Because the power of stem cell therapeutics is largely the result of molecules that stem cells release (Maguire, 2013). The molecules are packaged into exosomes, a smart nanosphere that is naturally produced by the stem cells (Maguire, 2016), resulting ... [Show full abstract] in protection, perfusion, and delivery of the molecules in a synergistic fashion – i.e. all the molecule types are delivered to the target at the same time and in the same space, yielding synergistic, systems-level effects (Maguire, 2014). The molecules contained in the exosomes include microRNA and proteins, such as heat shock proteins, chaperones, antioxidants, growth factors, and proteasomes. For the exosomes that are released from healthy cells to rescue neurodegenerative cells, an intact extracellular matrix (ECM) is required, along with a tunneling nanotube (TNT) emanating from the cell at risk to the healthy cell. Exosomes are known to rescue neurons by, for example, delivering HSPs and chaperones to repair misfolded, prion-like proteins. Considering neurodegenerative diseases, often the ECM is dysfunctional and not permissive to the formation of TNTs to transmit the exosomes from the healthy cell to the diseased neuron, or other diseased neural cell types. Our goal is to make exosomes with attached TNTs that can be perfused into patients with neurodegenerative diseases, such that the exosomes with added TNT constructs can attach to the diseased neurons and deliver their contents for initiating cellular rescue.