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Abstract
A systematic review of published data on oral submucous fibrosis is presented with special reference to its treatment modalities. Typically different medical and surgical modalities are considered that contribute to symptomatic relief and palliative functional improvement to the patients. Eventually, the magnitude of the illness as a pre-malignant disease in a considerable size of patients signifies the need for promising treatment options.
... Majority of the patients diagnosed with OSF are between the age of 20 -40years and shows a malignant transformation rate of about 7 to 13% [7]. Oral submucous fibrosis (OSMF) is a chronic inflammatory disease of the oral soft tissues with progressive juxta-epithelial fibrosis resulting in increasing difficulty in chewing, swallowing, speaking and mouth opening, often associated with burning sensation inside oral cavity that is aggravated on exposure to spicy food [8]. ...
... The habit of chewing betel nut (Areca catechu) is well-thoughtout to be the key etiological agent, with others factors being genetic predisposition, infections and viral agents, carcinogens, nutritional and immunologic factors. 8 The role of chilli in the pathogenesis of OSMF still is debatable and is projected to be an allergic response to capsaicin owing to allergen induced eosinophilia [5]. The combination of areca nut as well as tobacco has steered to a sharp upsurge in the occurrence of OSMF [4]. ...
... Inability/restricted mouth opening complemented with burning sensation are the chief compliant (s) of the patient. Scrutiny shows blanched oral mucosa with marble-like appearance, attributed to inflammation, trailed by hypovascularity and fibrosis that may be associated with small vesicles and mucosal erosions [8]. ...
... Oral submucous fibrosis (OSMF) is a chronic inflammatory disease of the oral soft tissues with progressive juxta-epithelial fibrosis resulting in increasing difficulty in chewing, swallowing, speaking and mouth opening, often associated with burning sensation inside oral cavity that is aggravated on exposure to spicy food [8]. The habit of chewing betel nut (Areca catechu) is considered to be the main etiological agent, with others factors being genetic predisposition, infections and viral agents, carcinogens, nutritional and immunologic factors [8]. ...
... Oral submucous fibrosis (OSMF) is a chronic inflammatory disease of the oral soft tissues with progressive juxta-epithelial fibrosis resulting in increasing difficulty in chewing, swallowing, speaking and mouth opening, often associated with burning sensation inside oral cavity that is aggravated on exposure to spicy food [8]. The habit of chewing betel nut (Areca catechu) is considered to be the main etiological agent, with others factors being genetic predisposition, infections and viral agents, carcinogens, nutritional and immunologic factors [8]. The role of chilliin the pathogenesis of OSMF remains controversial and is postulated as an hypersensitivity reaction to capsaicin due to allergen induced eosinophilia [6]. ...
... Concomitant to tobacco chewing, smoking and consumption of alcohol increases the risk of oropharyngeal malignancies. 7% to 13% lesions of OSMF can transform into oral cancer, especially squamous-cell carcinoma over a period of 10 years [6][7][8]. ...
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