The FAIR Guiding Principles for scientific data management and stewardship

Abstract

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders—representing academia, industry, funding agencies, and scholarly publishers—have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community.

Full text

Comment: The FAIR Guiding
Principles for scientific data
management and stewardship
Mark D. Wilkinson et al.
#
There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse
set of stakeholders—representing academia, industry, funding agencies, and scholarly publishers—have
come together to design and jointly endorse a concise and measureable set of principles that we refer
to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to
enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human
scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically
find and use the data, in addition to supporting its reuse by individuals. This Comment is the first
formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar
implementations in the community.
Supporting discovery through good data management
Good data management is not a goal in itself, but rather is the key conduit leading to knowledge
discovery and innovation, and to subsequent data and knowledge integration and reuse by the
community after the data publication process. Unfortunately, the existing digital ecosystem
surrounding scholarly data publication prevents us from extracting maximum benefitfromour
research investments (e.g., ref. 1). Partially in response to this, science funders, publishers and
governmental agencies are beginning to require data management and stewardship plans for data
generated in publicly funded experiments. Beyond proper collection, annotation, and archival, data
stewardship includes the notion of ‘long-term care’of valuable digital assets, with the goal that they
should be discovered and re-used for downstream investigations, either alone, or in combination with
newly generated data. The outcomes from good data management and stewardship, therefore, are
high quality digital publications that facilitate and simplify this ongoing process of discovery, evaluation,
and reuse in downstream studies. What constitutes ‘good data management’is, however, largely
undefined, and is generally left as a decision for the data or repository owner. Therefore, bringing some
clarity around the goals and desiderata of good data management and stewardship, and defining
simple guideposts to inform those who publish and/or preserve scholarly data, would be of great utility.
This article describes four foundational principles—Findability, Accessibility, Interoperability, and
Reusability—that serve to guide data producers and publishers as they navigate around these
obstacles, thereby helping to maximize the added-value gained by contemporary, formal scholarly
digital publishing. Importantly, it is our intent that the principles apply not only to ‘data’in the
conventional sense, but also to the algorithms, tools, and workflows that led to that data. All
scholarly digital research objects
2
—from data to analytical pipelines—benefit from application of
these principles, since all components of the research process must be available to ensure
transparency, reproducibility, and reusability.
There are numerous and diverse stakeholders who stand to benefit from overcoming these obstacles:
researchers wanting to share, get credit, and reuse each other’s data and interpretations; professional
data publishers offering their services; software and tool-builders providing data analysis and
processing services such as reusable workflows; funding agencies (private and public) increasingly
Correspondence and requests for materials should be addressed to B.M. (email: barend.mons@dtls.nl).
#A full list of authors and their affiliations appears at the end of the paper.
OPEN
SUBJECT CATEGORIES
» Research data
» Publication
characteristics
Received: 10 December 2015
Accepted: 12 February 2016
Published: 15 March 2016
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SCIENTIFIC DATA |3:160018 |DOI: 10.1038/sdata.2016.18 1

concerned with long-term data stewardship; and a data science community mining, integrating and
analysing new and existing data to advance discovery. To facilitate the reading of this manuscript by
these diverse stakeholders, we provide definitions for common abbreviations in Box 1. Humans,
however, are not the only critical stakeholders in the milieu of scientific data. Similar problems are
encountered by the applications and computational agents that we task to undertake data retrieval
and analysis on our behalf. These ‘computational stakeholders’are increasingly relevant, and demand
as much, or more, attention as their importance grows. One of the grand challenges of data-intensive
science, therefore, is to improve knowledge discovery through assisting both humans, and their
computational agents, in the discovery of, access to, and integration and analysis of, task-appropriate
scientific data and other scholarly digital objects.
For certain types of important digital objects, there are well-curated, deeply-integrated,
special-purpose repositories such as Genbank
3
, Worldwide Protein Data Bank (wwPDB
4
), and
UniProt
5
in the life sciences; Space Physics Data Facility (SPDF; http://spdf.gsfc.nasa.gov/) and Set of
Identifications, Measurements and Bibliography for Astronomical Data (SIMBAD
6
) in the space
sciences. These foundational and critical core resources are continuously curating and capturing high-
value reference datasets and fine-tuning them to enhance scholarly output, provide support for both
human and mechanical users, and provide extensive tooling to access their content in rich, dynamic
ways. However, not all datasets or even data types can be captured by, or submitted to, these
repositories. Many important datasets emerging from traditional, low-throughput bench science don’t
fit in the data models of these special-purpose repositories, yet these datasets are no less important
with respect to integrative research, reproducibility, and reuse in general. Apparently in response to
this, we see the emergence of numerous general-purpose data repositories, at scales ranging from
institutional (for example, a single university), to open globally-scoped repositories such as Dataverse
7
,
FigShare (http://figshare.com), Dryad
8
, Mendeley Data (https://data.mendeley.com/), Zenodo (http://
zenodo.org/), DataHub (http://datahub.io), DANS (http://www.dans.knaw.nl/), and EUDat
9
. Such
repositories accept a wide range of data types in a wide variety of formats, generally do not attempt
to integrate or harmonize the deposited data, and place few restrictions (or requirements) on the
descriptors of the data deposition. The resulting data ecosystem, therefore, appears to be moving
away from centralization, is becoming more diverse, and less integrated, thereby exacerbating the
discovery and re-usability problem for both human and computational stakeholders.
Aspecific example of these obstacles could be imagined in the domain of gene regulation and expression
analysis. Suppose a researcher has generated a dataset of differentially-selected polyadenylation sites in
a non-model pathogenic organism grown under a variety of environmental conditions that stimulate its
pathogenic state. The researcher is interested in comparing the alternatively-polyadenylated genes in
this local dataset, to other examples of alternative-polyadenylation, and the expression levels of these
genes—both in this organism and related model organisms—during the infection process. Given that
there is no special-purpose archive for differential polyadenylation data, and no model organism
database for this pathogen, where does the researcher begin?
We will consider the current approach to this problem from a variety of data discovery and integration
perspectives. If the desired datasets existed, where might they have been published, and how would
one begin to search for them, using what search tools? The desired search would need to filter based
on specific species, specific tissues, specific types of data (Poly-A, microarray, NGS), specific
conditions (infection), and specific genes—is that information (‘metadata’) captured by the
repositories, and if so, what formats is it in, is it searchable, and how? Once the data is discovered,
can it be downloaded? In what format(s)? Can that format be easily integrated with private in-house
data (the local dataset of alternative polyadenylation sites) as well as other data publications from
third-parties and with the community’s core gene/protein data repositories? Can this integration be
Box 1|Terms and Abbreviations
BD2K—Big Data 2Knowledge, is a trans-NIH initiative established to enable biomedical research as a digital research enterprise, to facilitate discovery and
support new knowledge, and to maximise community engagement.
DOI—Digital Object Identifier; a code used to permanently and stably identify (usually digital) objects. DOIs provide a standard mechanism for retrieval of
metadata about the object, and generally a means to access the data object itself.
FAIR—Findable, Accessible, Interoperable, Reusable.
FORCE11—The Future of Research Communications and e-Scholarship; a community of scholars, librarians, archivists, publishers and research funders that
has arisen organically to help facilitate the change toward improved knowledge creation and sharing, initiated in 2011.
Interoperability—the ability of data or tools from non-cooperating resources to integrate or work together with minimal effort.
JDDCP—Joint Declaration of Data Citation Principles; Acknowledging data as a first-class research output, and to support good research practices around
data re-use, JDDCP proposes a set of guiding principles for citation of data within scholarly literature, another dataset, or any other research object.
RDF—Resource Description Framework; a globally-accepted framework for data and knowledge representation that is intended to be read and interpreted
by machines.
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done automatically to save time and avoid copy/paste errors? Does the researcher have permission to
use the data from these third-party researchers, under what license conditions, and who should be
cited if a data-point is re-used?
Questions such as these highlight some of the barriers to data discovery and reuse, not only for
humans, but even more so for machines; yet it is precisely these kinds of deeply and broadly
integrative analyses that constitute the bulk of contemporary e-Science. The reason that we often
need several weeks (or months) of specialist technical effort to gather the data necessary to answer
such research questions is not the lack of appropriate technology; the reason is, that we do not pay
our valuable digital objects the careful attention they deserve when we create and preserve them.
Overcoming these barriers, therefore, necessitates that all stakeholders—including researchers,
special-purpose, and general-purpose repositories—evolve to meet the emergent challenges
described above. The goal is for scholarly digital objects of all kinds to become ‘first class citizens’
in the scientific publication ecosystem, where the quality of the publication—and more importantly,
the impact of the publication—is a function of its ability to be accurately and appropriately found, re-
used, and cited over time, by all stakeholders, both human and mechanical.
With this goal in-mind, a workshop was held in Leiden, Netherlands, in 2014, named ‘Jointly
Designing a Data Fairport’. This workshop brought together a wide group of academic and private
stakeholders all of whom had an interest in overcoming data discovery and reuse obstacles. From the
deliberations at the workshop the notion emerged that, through the definition of, and widespread
support for, a minimal set of community-agreed guiding principles and practices, all stakeholders
could more easily discover, access, appropriately integrate and re-use, and adequately cite, the vast
quantities of information being generated by contemporary data-intensive science. The meeting
concluded with a draft formulation of a set of foundational principles that were subsequently
elaborated in greater detail—namely, that all research objects should be Findable, Accessible,
Interoperable and Reusable (FAIR) both for machines and for people. These are now referred to as the
FAIR Guiding Principles. Subsequently, a dedicated FAIR working group, established by several
members of the FORCE11 community
10
fine-tuned and improved the Principles. The results of these
efforts are reported here.
The significance of machines in data-rich research environments
The emphasis placed on FAIRness being applied to both human-driven and machine-driven activities,
is a specific focus of the FAIR Guiding Principles that distinguishes them from many peer initiatives
(discussed in the subsequent section). Humans and machines often face distinct barriers when
attempting to find and process data on the Web. Humans have an intuitive sense of ‘semantics’(the
meaning or intent of a digital object) because we are capable of identifying and interpreting a wide
variety of contextual cues, whether those take the form of structural/visual/iconic cues in the layout of
a Web page, or the content of narrative notes. As such, we are less likely to make errors in the
selection of appropriate data or other digital objects, although humans will face similar difficulties if
sufficient contextual metadata is lacking. The primary limitation of humans, however, is that we are
unable to operate at the scope, scale, and speed necessitated by the scale of contemporary scientific
data and complexity of e-Science. It is for this reason that humans increasingly rely on computational
agents to undertake discovery and integration tasks on their behalf. This necessitates machines to be
capable of autonomously and appropriately acting when faced with the wide range of types, formats,
and access-mechanisms/protocols that will be encountered during their self-guided exploration of the
global data ecosystem. It also necessitates that the machines keep an exquisite record of provenance
such that the data they are collecting can be accurately and adequately cited. Assisting these agents,
therefore, is a critical consideration for all participants in the data management and stewardship
process—from researchers and data producers to data repository hosts.
Throughout this paper, we use the phrase ‘machine actionable’to indicate a continuum of possible
states wherein a digital object provides increasingly more detailed information to an autonomously-
acting, computational data explorer. This information enables the agent—to a degree dependent on
the amount of detail provided—to have the capacity, when faced with a digital object never
encountered before, to: a) identify the type of object (with respect to both structure and intent), b)
determine if it is useful within the context of the agent’s current task by interrogating metadata and/
or data elements, c) determine if it is usable, with respect to license, consent, or other accessibility or
use constraints, and d) take appropriate action, in much the same manner that a human would.
For example, a machine may be capable of determining the data-type of a discovered digital object,
but not capable of parsing it due to it being in an unknown format; or it may be capable of processing
the contained data, but not capable of determining the licensing requirements related to the retrieval
and/or use of that data. The optimal state—where machines fully ‘understand’and can autonomously
and correctly operate-on a digital object—may rarely be achieved. Nevertheless, the FAIR principles
provide ‘steps along a path’toward machine-actionability; adopting, in whole or in part, the FAIR
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principles, leads the resource along the continuum towards this optimal state. In addition, the idea of
being machine-actionable applies in two contexts—first, when referring to the contextual metadata
surrounding a digital object (‘what is it?’), and second, when referring to the content of the digital
object itself (‘how do I process it/integrate it?’). Either, or both of these may be machine-actionable,
and each forms its own continuum of actionability.
Finally, we wish to draw a distinction between data that is machine-actionable as a result of specific
investment in software supporting that data-type, for example, bespoke parsers that understand life
science wwPDB files or space science Space Physics Archive Search and Extract (SPASE) files, and
data that is machine-actionable exclusively through the utilization of general-purpose, open
technologies. To reiterate the earlier point—ultimate machine-actionability occurs when a machine
can make a useful decision regarding data that it has not encountered before. This distinction is
important when considering both (a) the rapidly growing and evolving data environment, with new
technologies and new, more complex data-types continuously being developed, and (b) the growth of
general-purpose repositories, where the data-types likely to be encountered by an agent are
unpredictable. Creating bespoke parsers, in all computer languages, for all data-types and all
analytical tools that require those data-types, is not a sustainable activity. As such, the focus on
assisting machines in their discovery and exploration of data through application of more generalized
interoperability technologies and standards at the data/repository level, becomes a first-priority for
good data stewardship.
The FAIR Guiding Principles in detail
Representatives of the interested stakeholder-groups, discussed above, coalesced around four core
desiderata—the FAIR Guiding Principles—and limited elaboration of these, which have been refined
(Box 2) from the meeting’s original draft, available at (https://www.force11.org/node/6062). A
separate document that dynamically addresses community discussion relating to clarifications and
explanations of the principles, and detailed guidelines for and examples of FAIR implementations, is
currently being constructed (http://datafairport.org/fair-principles-living-document-menu). The FAIR
Guiding Principles describe distinct considerations for contemporary data publishing environments
with respect to supporting both manual and automated deposition, exploration, sharing, and reuse.
While there have been a number of recent, often domain-focused publications advocating for specific
improvements in practices relating to data management and archival
1,11,12
, FAIR differs in that it
describes concise, domain-independent, high-level principles that can be applied to a wide range of
scholarly outputs. Throughout the Principles, we use the phrase ‘(meta)data’in cases where the
Principle should be applied to both metadata and data.
The elements of the FAIR Principles are related, but independent and separable. The Principles define
characteristics that contemporary data resources, tools, vocabularies and infrastructures should
exhibit to assist discovery and reuse by third-parties. By minimally defining each guiding principle, the
barrier-to-entry for data producers, publishers and stewards who wish to make their data holdings
FAIR is purposely maintained as low as possible. The Principles may be adhered to in any combination
and incrementally, as data providers’publishing environments evolve to increasing degrees of
‘FAIRness’. Moreover, the modularity of the Principles, and their distinction between data and
metadata, explicitly support a wide range of special circumstances. One such example is highly
sensitive or personally-identifiable data, where publication of rich metadata to facilitate discovery,
including clear rules regarding the process for accessing the data, provides a high degree of ‘FAIRness’
even in the absence of FAIR publication of the data itself. A second example involves the publication
Box 2|The FAIR Guiding Principles
To be Findable:
F1. (meta)data are assigned a globally unique and persistent identifier
F2. data are described with rich metadata (defined by R1below)
F3. metadata clearly and explicitly include the identifier of the data it describes
F4. (meta)data are registered or indexed in a searchable resource
To be Accessible:
A1. (meta)data are retrievable by their identifier using a standardized communications protocol
A1.1the protocol is open, free, and universally implementable
A1.2the protocol allows for an authentication and authorization procedure, where necessary
A2. metadata are accessible, even when the data are no longer available
To be Interoperable:
I1. (meta)data use a formal, accessible, shared, and broadly applicable language for knowledge representation.
I2. (meta)data use vocabularies that follow FAIR principles
I3. (meta)data include qualified references to other (meta)data
To be Reusable:
R1. meta(data) are richly described with a plurality of accurate and relevant attributes
R1.1. (meta)data are released with a clear and accessible data usage license
R1.2. (meta)data are associated with detailed provenance
R1.3. (meta)data meet domain-relevant community standards
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of non-data research objects. Analytical workflows, for example, are a critical component of the
scholarly ecosystem, and their formal publication is necessary to achieve both transparency and
scientific reproducibility. The FAIR principles can equally be applied to these non-data assets, which
need to be identified, described, discovered, and reused in much the same manner as data.
Specific exemplar efforts that provide varying levels of FAIRness are detailed later in this document.
Additional issues, however, remain to be addressed. First, when community-endorsed vocabularies or
other (meta)data standards do not include the attributes necessary to achieve rich annotation, there
are two possible solutions: either publish an extension of an existing, closely related vocabulary, or—in
the extreme case—create and explicitly publish a new vocabulary resource, following FAIR principles
(‘I2’). Second, to explicitly identify the standard chosen when more than one vocabulary or other
(meta)data standard is available, and given that for instance in the life sciences there are over 600
content standards, the BioSharing registry (https://biosharing.org/) can be of use as it describes the
standards in detail, including versions where applicable.
The Principles precede implementation
These high-level FAIR Guiding Principles precede implementation choices, and do not suggest any
specific technology, standard, or implementation-solution; moreover, the Principles are not,
themselves, a standard or a specification. They act as a guide to data publishers and stewards to
assist them in evaluating whether their particular implementation choices are rendering their digital
research artefacts Findable, Accessible, Interoperable, and Reusable. We anticipate that these high
level principles will enable a broad range of integrative and exploratory behaviours, based on a wide
range of technology choices and implementations. Indeed, many repositories are already
implementing various aspects of FAIR using a variety of technology choices and several examples
are detailed in the next section; examples include Scientific Data itself and how narrative data articles
are anchored to a progressively FAIR structured metadata.
Examples of FAIRness, and the resulting value-added
Dataverse
7
: Dataverse is an open-source data repository software installed in dozens of institutions
globally to support public community repositories or institutional research data repositories. Harvard
Dataverse, with more than 60,000 datasets, is the largest of the current Dataverse repositories, and is
open to all researchers from all research fields. Dataverse generates a formal citation for each deposit,
following the standard defined by Altman and King
13
. Dataverse makes the Digital Object Identifier
(DOI), or other persistent identifiers (Handles), public when the dataset is published (‘F’). This resolves
to a landing page, providing access to metadata, data files, dataset terms, waivers or licenses, and
version information, all of which is indexed and searchable (‘F’,‘A’, and ‘R’). Deposits include
metadata, data files, and any complementary files (such as documentation or code) needed to
understand the data and analysis (‘R’). Metadata is always public, even if the data are restricted or
removed for privacy issues (‘F’,‘A’). This metadata is offered at three levels, extensively supporting the
‘I’and ‘R’FAIR principles: 1) data citation metadata, which maps to DataCite schema or Dublin Core
Terms, 2) domain-specific metadata, which when possible maps to metadata standards used within a
scientific domain, and 3)file-level metadata, which can be deep and extensive for tabular data files
(including column-level metadata). Finally, Dataverse provides public machine-accessible interfaces to
search the data, access the metadata and download the data files, using a token to grant access when
data files are restricted (‘A’).
FAIRDOM (http://fair-dom.org/about): integrates the SEEK
14
and openBIS
15
platforms to produce a
FAIR data and model management facility for Systems Biology. Individual research assets (or
aggregates of data and models) are identified with unique and persistent HTTP URLs, which can be
registered with DOIs for publication (‘F’). Assets can be accessed over the Web in a variety of formats
appropriate for individuals and/or their computers (RDF, XML) (‘I’). Research assets are annotated with
rich metadata, using community standards, formats and ontologies (‘I’). The metadata is stored as
RDF to enable interoperability and assets can be downloaded for reuse (‘R’).
ISA
16
: is a community-driven metadata tracking framework to facilitate standards-compliant
collection, curation, management and reuse of life science datasets. ISA provides progressively FAIR
structured metadata to Nature Scientific Data’s Data Descriptor articles, and many GigaScience data
papers, and underpins the EBI MetaboLights database among other data resources. At the heart is a
general-purpose, extensible ISA model, originally only available as a tabular representation but
subsequently enhanced as an RDF-based representation
17
, and JSON serializations to enable the ‘I’
and ‘R’, becoming ‘FAIR’when published as linked data (http://elixir-uk.org/node-events/201cisa-as-a-
fair-research-object201d-hack-the-spec-event-1) and complementing other research objects
18
.
Open PHACTS
19
: Open PHACTS is a data integration platform for information pertaining to drug
discovery. Access to the platform is mediated through a machine-accessible interface
20
which
provides multiple representations that are both human (HTML) and machine readable (RDF, JSON,
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XML, CSV, etc), providing the ‘A’facet of FAIRness. The interface allows multiple URLs to be used to
access information about a particular entity through a mappings service (‘F’and ‘A’). Thus, a user can
provide a ChEMBL URL to retrieve information sourced from, for example, Chemspider or DrugBank.
Each call provides a canonical URL in its response (‘A’and ‘I’). All data sources used are described
using standardized dataset descriptions, following the global VoID standard, with rich provenance (‘R’
and ‘I’). All interface features are described using RDF following the Linked Data API specification (‘A’).
Finally, a majority of the datasets are described using community agreed upon ontologies (‘I’).
wwPDB
4,21
: wwPDB is a special-purpose, intensively-curated data archive that hosts information
about experimentally-determined 3D structures of proteins and nucleic acids. All wwPDB entries are
stably hosted on an FTP server (‘A’) and represented in machine-readable formats (text and XML); the
latter are machine-actionable using the metadata provided by the wwPDB conforming to the
Macromolecular Information Framework (mmCIF
22
), a data standard of the International Union of
Crystallography (IUCr) (‘F’,‘I’for humans, ‘F’,‘I’for IUCr-aware machines). The wwPDB metadata
contains cross-references to common identifiers such as PubMed and NCBI Taxonomy, and their
wwPDB metadata are described in data dictionaries and schema documents (http://mmcif.wwpdb.org
and http://pdbml.wwpdb.org) which conform to the IUCr data standard for the chemical and
structural biology domains (‘R’). A variety of software tools are available to interpret both wwPDB
data and meta-data (‘I’,‘R’for humans, ‘I’,‘R’for machines with this software). Each entry is
represented by a DOI (‘F’,‘A’for humans and machines). The DOI resolves to a zipped file which
requires special software for further interrogation/interpretation. Other wwPDB access points
23–25
provide access to wwPDB records through URLs that are likely to be stable in the long-term (‘F’), and
all data and metadata is searchable through one or more of the wwPDB-affiliated websites (‘F’)
UniProt
26
: UniProt is a comprehensive resource for protein sequence and annotation data. All entries
are uniquely identified by a stable URL, that provides access to the record in a variety of formats
including a web page, plain-text, and RDF (‘F’and ‘A’). The record contains rich metadata (‘F’) that is
both human-readable (HTML) and machine-readable (text and RDF), where the RDF formatted
response utilizes shared vocabularies and ontologies such as UniProt Core, FALDO, and ECO (‘I’).
Interlinking with more than 150 different databases, every UniProt record has extensive links into, for
example, PubMed, enabling rich citation. These links are machine-actionable in the RDF
representation (‘R’). Finally, in the RDF representation, the UniProt Core Ontology explicitly types
all records, leaving no ambiguity—neither for humans nor machines—about what the data represents
(‘R’), enabling fully-automated retrieval of records and cross-referencing information.
In addition to, and in support of, communities and resources that are already pursuing FAIR
objectives, the Data Citation Implementation Group of Force11 has published specific technical
recommendations for how to implement many of the principles
27
, with a particular focus on
identifiers and their resolution, persistence, and metadata accessibility especially related to citation.
In addition, the ‘Skunkworks’group that emerged from the Lorentz Workshop has been creating
software supporting infrastructures
28
that are, end-to-end, compatible with FAIR principles, and can
be implemented over existing repositories. These code modules have a particular focus on metadata
publication and searchability, compatibility in cases of strict privacy considerations, and the extremely
difficult problem of data and metadata interoperability (manuscript in preparation). Finally, there are
several emergent projects, some listed in Box 3, for which FAIR is a key objective. These projects may
provide valuable advice and guidance for those wishing to become more FAIR.
FAIRness is a prerequisite for proper data management and data stewardship
The ideas within the FAIR Guiding Principles reflect, combine, build upon and extend previous work by
both the Concept Web Alliance (https://conceptweblog.wordpress.com/) partners, who focused on
machine-actionability and harmonization of data structures and semantics, and by the scientific and
scholarly organizations that developed the Joint Declaration of Data Citation Principles (JDDCP
29
),
Box 3|Emergent community/collaborative initiatives with FAIR as a core focus or activity
bioCADDIE (https://biocaddie.org): The NIH BD2K biomedical and healthCAre Data Discovery Index Ecosystem (bioCADDIE) consortium works to develop a
Data Discovery Index (DDI) prototype, which is set to be as transformative and impactful for data as PubMed for the biomedical literature
30
. The DDI focuses
on finding (‘F’) and accessing (‘A’) the datasets stored across different sources, and progressively works to identify relevant metadata
31
(‘I’) and maps them to
community standards (‘R’), linking to BioSharing.
CEDAR
32
: The Center for Expanded Data Annotation and Retrieval (CEDAR) is an NIH BD2K funded center of excellence to develop tools and technologies
that reduce the burden of authoring and enhancing metadata that meet community-based standards. CEDAR will enable the creation of metadata templates
that implement community based standards for experimental metadata, from BioSharing (https://biosharing.org), and that will be uniquely identifiable and
retrievable with HTTP URIs, and annotated with vocabularies and ontologies drawn from BioPortal (http://bioportal.bioontology.org) (‘F’,‘A’,‘I’,‘R’). These
templates will guide users to create rich metadata with unique and stable HTTP identifiers (‘F’) that can be retrieved using HTTP (‘A’) and accessible in a
variety of formats (JSON-LD, TURTLE, RDF/XML, CSV, etc) (‘I’). These metadata will use community standards, as defined by the template, and include
provenance and data usage (‘R’).
These two projects, among others, provide tools and or collaborative opportunities for those who wish to improve the FAIRness of their data.
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who focused on primary scholarly data being made citable, discoverable and available for reuse, so as
to be capable of supporting more rigorous scholarship. An attempt to define the similarities and
overlaps between the FAIR Principles and the JDDCP is provided at (https://www.force11.org/node/
6062). The FAIR Principles are also complementary to the ‘Data Seal of Approval’(DSA) (http://
datasealofapproval.org/media/filer_public/2013/09/27/guidelines_2014-2015.pdf) in that they share
the general aim to render data re-usable for users other than those who originally generated them.
While the DSA focuses primarily on the responsibilities and conduct of data producers and
repositories, FAIR focuses primarily on the data itself. Clearly, the broader community of stakeholders
is coalescing around a set of common, dovetailed visions spanning all facets of the scholarly data
publishing ecosystem.
The end result, when implemented, will be more rigorous management and stewardship of these
valuable digital resources, to the benefit of the entire academic community. As stated at the outset,
good data management and stewardship is not a goal in itself, but rather a pre-condition supporting
knowledge discovery and innovation. Contemporary e-Science requires data to be Findable,
Accessible, Interoperable, and Reusable in the long-term, and these objectives are rapidly becoming
expectations of agencies and publishers. We demonstrate, therefore, that the FAIR Data Principles
provide a set of mileposts for data producers and publishers. They guide the implementation of
the most basic levels of good Data Management and Stewardship practice, thus helping researchers
adhere to the expectations and requirements of their funding agencies. We call on all data producers
and publishers to examine and implement these principles, and actively participate with the
FAIR initiative by joining the Force11 working group. By working together towards shared, common
goals, the valuable data produced by our community will gradually achieve the critical goals
of FAIRness.
References
1. Roche, D. G., Kruuk, L. E. B., Lanfear, R. & Binning, S. A. Public Data Archiving in Ecology and Evolution: How Well Are
We Doing? PLOS Biol. 13, e1002295 (2015).
2. Bechhofer, S. et al. Research Objects: Towards Exchange and Reuse of Digital Knowledge. Nat. Preced. doi:10.1038/
npre.2010.4626.1 (2010).
3. Benson, D. A. et al. GenBank. Nucleic Acids Res. 41, D36–D42 (2013).
4. Berman, H., Henrick, K. & Nakamura, H. Announcing the worldwide Protein Data Bank. Nat. Struct. Biol. 10, 980–980 (2003).
5. The Uniprot Consortium. UniProt: a hub for protein information. Nucleic Acids Res. 43, D204–D212 (2015).
6. Wenger, M. et al. The SIMBAD astronomical database-The CDS reference database for astronomical objects. Astron. Astrophys.
Suppl. Ser. 143, 9–22 (2000).
7. Crosas, M. "The Dataverse Network
®
: An Open-Source Application for Sharing, Discovering and Preserving Data". D-Lib Mag 17
(1),p2 (2011).
8. White, H. C., Carrier, S., Thompson, A., Greenberg, J. & Scherle, R. The Dryad data repository: A Singapore framework metadata
architecture in a DSpace environment. Univ. Göttingen, p157 (2008).
9. Lecarpentier, D. et al. EUDAT: A New Cross-Disciplinary Data Infrastructure for Science. Int. J. Digit. Curation 8,
279–287 (2013).
10. Martone, M. E. FORCE11: Building the Future for Research Communications and e-Scholarship. Bioscience 65, 635 (2015).
11. White, E. et al. Nine simple ways to make it easier to (re)use your data. Ideas Ecol. Evol. 6(2013).
12. Sandve, G. K., Nekrutenko, A., Taylor, J. & Hovig, E. Ten Simple Rules for Reproducible Computational Research. PLoS Comput.
Biol. 9, e1003285 (2013).
13. Altman, M. & King, G. in D-Lib Magazine 13, no. 3/4 (2007).
14. Wolstencroft, K. et al. SEEK: a systems biology data and model management platform. BMC Syst. Biol. 9, 33 (2015).
15. Bauch, A. et al. openBIS: a flexible framework for managing and analyzing complex data in biology research. BMC Bioinformatics
12, 468 (2011).
16. Sansone, S.-A. et al. Toward interoperable bioscience data. Nat. Genet. 44, 121–126 (2012).
17. González-Beltrán, A., Maguire, E., Sansone, S.-A. & Rocca-Serra, P. linkedISA: semantic representation of ISA-Tab experimental
metadata. BMC Bioinformatics 15, S4 (2014).
18. González-Beltrán, A. et al. From Peer-Reviewed to Peer-Reproduced in Scholarly Publishing: The Complementary Roles of Data
Models and Workflows in Bioinformatics. PLoS ONE 10, e0127612 (2015).
19. Harland, L. Open PHACTS: A Semantic Knowledge Infrastructure for Public and Commercial Drug Discovery Research. Knowl.
Eng. Knowl. Manag. Lect. Notes Comput. Sci. 7603/2012, 1–7 (2012).
20. Groth, P. et al. API-centric Linked Data integration: The Open PHACTS Discovery Platform case study. Web Semant. Sci. Serv.
Agents World Wide Web 29, 12–18 (2014).
21. Berman, H. M. et al. The Protein Data Bank. Nucleic Acids Res. 28, 235–242 (2000).
22. Bourne, P. E., Berman, H. M., Watenpaugh, K., Westbrook, J. D. & Fitzgerald, P. M. D. The macromolecular crystallographic
information file (mmCIF). Meth. Enzym 277, 571–590 (1997).
23. Rose, P. W. et al. The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. Nucleic
Acids Res. 43, D345–D356 (2015).
24. Kinjo, A. R. et al. Protein Data Bank Japan (PDBj): maintaining a structural data archive and resource description
framework format. Nucleic Acids Res. 40, D453–D460 (2012).
25. Gutmanas, A. et al. PDBe: Protein Data Bank in Europe. Nucleic Acids Res. 42, D285–D291 (2014).
26. UniProt Consortium. UniProt: a hub for protein information. Nucleic Acids Res. 43, D204–D212 (2015).
27. Starr, J. et al. Achieving human and machine accessibility of cited data in scholarly publications. PeerJ Comput. Sci. 1, e1 (2015).
28. Wilkinson, M., Dumontier, M. & Durbin, P. DataFairPort: The Perl libraries version 0.231 doi:10.5281/zenodo.33584 (2015).
29. Data Citation Synthesis Group: Joint Declaration of Data Citation Principles. San Diego CA: FORCE11. https://www.force11.org/
datacitation (2014).
30. Ohno-machado, L. et al. NIH BD2K bioCADDIE white paper—Data Discovery Index. http://dx.doi.org/10.6084/m9.fig-
share.1362572 (2015).
www.nature.com/sdata/
SCIENTIFIC DATA |3:160018 |DOI: 10.1038/sdata.2016.18 7

31. NIH BD2K bioCADDIE WG3 Members. WG3-MetadataSpecifications: NIH BD2K bioCADDIE Data Discovery Index WG3
Metadata Specification v1 doi:10.5281/zenodo.28019 (2015).
32. Musen, M. A. et al. The center for expanded data annotation and retrieval. J. Am. Med. Informatics Assoc. 22, 1148–1152 (2015).
Acknowledgements
The original Lorentz Workshop ‘Jointly Designing a Data FAIRport’was organized by Barend Mons in
collaboration with and co-sponsored by the Lorentz center, The Dutch Techcenter for the Life Sciences
and the Netherlands eScience Center. The principles and themes described in this manuscript represent
the significant voluntary contributions and participation of the authors at, and/or subsequent to, this
workshop and from the wider Force11, BD2K and ELIXIR communities. We also acknowledge and thank
the organizers and backers of the NBDC/DBCLS BioHackathon 2015, where several of the authors made
significant revisions to the FAIR Principles.
Author Contributions
M.W. was the primary author of the manuscript, and participated extensively in the drafting and editing
of the FAIR Principles. M.D. was significantly involved in the drafting of the FAIR Principles. B.M.
conceived of the FAIR Data Initiative, contributed extensively to the drafting of the principles, and to this
manuscript text. All other authors are listed alphabetically, and contributed to the manuscript either by
their participation in the initial workshop and/or by editing or commenting on the manuscript text.
Additional Information
Competing financial interests: M.A. is the Nature Genetics’Editor in Chief; S.A.S. is Scientific Data’s
Honorary Academic Editor and consultant.
How to cite this article: Wilkinson, M. D. et al. The FAIR Guiding Principles for scientific data
management and stewardship. Sci. Data 3:160018 doi: 10.1038/sdata.2016.18 (2016).
This work is licensed under a Creative Commons Attribution 4.0 International License. The
images or other third party material in this article are included in the article’s Creative
Commons license, unless indicated otherwise in the credit line; if the material is not included under the
Creative Commons license, users will need to obtain permission from the license holder to reproduce the
material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0
Mark D. Wilkinson
1
, Michel Dumontier
2
, IJsbrand Jan Aalbersberg
3
, Gabrielle Appleton
3
,
Myles Axton
4
, Arie Baak
5
, Niklas Blomberg
6
, Jan-Willem Boiten
7
,
Luiz Bonino da Silva Santos
8
, Philip E. Bourne
9
, Jildau Bouwman
10
, Anthony J. Brookes
11
,
Tim Clark
12
, Mercè Crosas
13
, Ingrid Dillo
14
, Olivier Dumon
3
, Scott Edmunds
15
,
Chris T. Evelo
16
, Richard Finkers
17
, Alejandra Gonzalez-Beltran
18
, Alasdair J.G. Gray
19
,
Paul Groth
3
, Carole Goble
20
, Jeffrey S. Grethe
21
, Jaap Heringa
22
, Peter A.C. ’t Hoen
23
,
Rob Hooft
24
, Tobias Kuhn
25
, Ruben Kok
22
, Joost Kok
26
, Scott J. Lusher
27
,
Maryann E. Martone
28
, Albert Mons
29
, Abel L. Packer
30
, Bengt Persson
31
,
Philippe Rocca-Serra
18
, Marco Roos
32
, Rene van Schaik
33
, Susanna-Assunta Sansone
18
,
Erik Schultes
34
, Thierry Sengstag
35
, Ted Slater
36
, George Strawn
37
, Morris A. Swertz
38
,
Mark Thompson
32
, Johan van der Lei
39
, Erik van Mulligen
39
, Jan Velterop
40
,
Andra Waagmeester
41
, Peter Wittenburg
42
, Katherine Wolstencroft
43
, Jun Zhao
44
& Barend Mons
45,46,47
1
Center for Plant Biotechnology and Genomics, Universidad Politécnica de Madrid, Madrid 28223, Spain.
2
Stanford University, Stanford 94305-5411, USA.
3
Elsevier, Amsterdam 1043 NX, The Netherlands.
4
Nature
Genetics, New York 10004-1562, USA.
5
Euretos and Phortos Consultants, Rotterdam 2741 CA, The Netherlands.
6
ELIXIR, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
7
Lygature, Eindhoven 5656 AG, The Netherlands.
8
Vrije Universiteit Amsterdam, Dutch Techcenter for Life Sciences, Amsterdam 1081 HV, The Netherlands.
9
Office of the Director, National Institutes of Health, Rockville 20892, USA.
10
TNO, Zeist 3700 AJ, The
Netherlands.
11
Department of Genetics, University of Leicester, Leicester LE17RH, UK.
12
Harvard Medical
School, Boston, Massachusetts MA 02115, USA.
13
Harvard University, Cambridge, Massachusetts MA 02138,
USA.
14
Data Archiving and Networked Services (DANS), The Hague 2593 HW, The Netherlands.
15
GigaScience,
Beijing Genomics Institute, Shenzhen 518083, China.
16
Department of Bioinformatics, Maastricht University,
Maastricht 6200 MD, The Netherlands.
17
Wageningen UR Plant Breeding, Wageningen 6708 PB, The
Netherlands.
18
Oxford e-Research Center, University of Oxford, Oxford OX13QG, UK.
19
Heriot-Watt University,
Edinburgh EH14 4AS, UK.
20
School of Computer Science, University of Manchester, Manchester M13 9PL, UK.
21
Center for Research in Biological Systems, School of Medicine, University of California San Diego, La Jolla,
California 92093-0446, USA.
22
Dutch Techcenter for the Life Sciences, Utrecht 3501 DE, The Netherlands.
23
Department of Human Genetics, Leiden University Medical Center, Dutch Techcenter for the Life Sciences,
Leiden 2300 RC, The Netherlands.
24
Dutch TechCenter for Life Sciences and ELIXIR-NL, Utrecht 3501 DE, The
www.nature.com/sdata/
SCIENTIFIC DATA |3:160018 |DOI: 10.1038/sdata.2016.18 8

Netherlands.
25
VU University Amsterdam, Amsterdam 1081 HV, The Netherlands.
26
Leiden Center of Data
Science, Leiden University, Leiden 2300 RA, The Netherlands.
27
Netherlands eScience Center, Amsterdam 1098
XG, The Netherlands.
28
National Center for Microscopy and Imaging Research, UCSD, San Diego 92103, USA.
29
Phortos Consultants, San Diego 92011, USA.
30
SciELO/FAPESP Program, UNIFESP Foundation, São Paulo
05468-901, Brazil.
31
Bioinformatics Infrastructure for Life Sciences (BILS), Science for Life Laboratory, Dept of
Cell and Molecular Biology, Uppsala University, S-751 24, Uppsala, Sweden.
32
Leiden University Medical Center,
Leiden 2333 ZA, The Netherlands.
33
Bayer CropScience, Gent Area 1831, Belgium.
34
Leiden Institute for
Advanced Computer Science, Leiden University Medical Center, Leiden 2300 RA, The Netherlands.
35
Swiss
Institute of Bioinformatics and University of Basel, Basel 4056, Switzerland.
36
Cray, Inc., Seattle 98164, USA.
37
Unaffiliated.
38
University Medical Center Groningen (UMCG), University of Groningen, Groningen 9713 GZ, The
Netherlands.
39
Erasmus MC, Rotterdam 3015 CE, The Netherlands.
40
Independent Open Access and Open
Science Advocate, Guildford GU13PW, UK.
41
Micelio, Antwerp 2180, Belgium.
42
Max Planck Compute and Data
Facility, MPS, Garching 85748, Germany.
43
Leiden Institute of Advanced Computer Science, Leiden University,
Leiden 2333 CA, The Netherlands.
44
Department of Computer Science, Oxford University, Oxford OX13QD, UK.
45
Leiden University Medical Center, Leiden and Dutch TechCenter for Life Sciences, Utrecht 2333 ZA, The
Netherlands.
46
Netherlands eScience Center, Amsterdam 1098 XG, The Netherlands.
47
Erasmus MC, Rotterdam
3015 CE, The Netherlands.
www.nature.com/sdata/
SCIENTIFIC DATA |3:160018 |DOI: 10.1038/sdata.2016.18 9