Extended shelf life of fruits is of prime importance to ensure their availability in the market and facilitate longer-distance transportation. In this case, effective pre-harvest treatments are crucial for managing the climacteric nature of mangoes by reducing post-harvest decay during storage. So, implementing pre-harvest spray of nutrients and bagging is vital to reduce deterioration and improve the quality of mango cv. ‘Amrapali’ in storage. A study assessed various interventions, including bagging, 2% CaCl2, 1.5% K2SO4, and 2% CaCl2 + 1.5% K2SO4 + bagging, in preserving postharvest quality and retarding fruit softening of mangoes at ambient storage (25 ± 3 ºC and 80–85% RH). Several physicochemical attributes and disease incidence at 0, 4, 8, 12, and 16 days of storage were analyzed. The findings indicated that 2% CaCl2 + 1.5% K2SO4 + bagging treatment appeared superior compared to control in terms of lower weight loss (5.10–10.84, 6.83–17.34%), pH (2.83–5.15, 3.00–5.48), decay incidence (0–9.87, 1.47–41.37%), ethylene production (0.21–0.84, 0.36–1.92 µl kg−1 h−1), respiration rate (2.92–27.03, 4.48–52.76 ml CO2 kg−1 h−1) while higher in fruit firmness (4.92–2.01, 4.41–1.23 kg cm−2), total soluble solids-TSS (11.67–17.60, 11.33–15.66º Brix), ascorbic acid content (39.86–11.26, 35.26–5.56 mg 100 g−1), total sugar (7.96–16.07, 3.82–14.52 mg 100 g−1), carotenoid (173.53–664.33, 67.00–567.00 µg 100 g−1), total phenol (163.53–113.58, 143.61–51.72 mg 100 g−1), DPPH scavenging activity (431.29–305.53, 308.65–228.49 µmol g−1). 2% CaCl2 + 1.5% K2SO4 + bagging treatment also showed better peel and pulp colour of mango fruits with greater values of L* (brightness), a* (redness), as well as b* (yellowness) compared to control. Notably, fruits that were treated with 2% CaCl2 + 1.5% K2SO4 + bagging had the lowest polyphenol oxidase (PPO), while control showed reduced activity of catalase (CAT) and peroxidase (POD). These findings suggest that 2% CaCl2 + 1.5% K2SO4 + bagging might be a successful approach to improving the quality and postharvest physiology of mangoes cv. Amrapali at ambient storage.