Vitamin B1 abnormalities in persons with fibromyalgia, myofascial pain syndrome and chronic alcoholism

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A study of plasma thiamin pyrophosphate (TPP), erythrocyte transketolase activity (TK), TK affinity for coenzyme (Km TPP), as well as whole blood pyruvate (Pyr) and pyruvate/lactate (Pyr/Lac) has been performed in 14 men and 22 women healthy control (20-25 years old), 4 men and 49 women, age matched fibromyalgia (FM) (ACR criteria) 5 men and 6 women with chronic alcoholism and 3 men and 5 women with myofascial pain syndrome (MPS). Pyr was significantly increased in alcoholics and FM ; Pyr/Lac was significantly increased in FM only. TK was decreased in alcoholics. Km was significantly increased in FM. TPP was significantly decreased in alcoholics and markedly increased in MPS. Nutritional thiamin abnormalities, observed in alcoholics and functional thiamin abnormalities observed in FM, are not demonstrated in MPS, in spite of a trend for increased pyr and pyr/lac.

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... All studies that investigated vitamin B12 (n = 1) [62], folic acid (n = 1) [62], iron (n = 2) [48,50], molybdenum (n = 1) [66], phosphorus (n = 4) [46,49,61,71,72] sodium (n = 3) [42,46,66], and iodine (n = 1) [66], and the majority of studies that investigated potassium (n = 3/4) [42,46,59], and selenium status (n = 4/5) [39,46,66,69] found no statistically significant difference between patients and controls (Table 3). In contrast, all studies that investigated vitamin B1 (n = 1/1) [54], and manganese (n = 1/1) [46], and the majority of studies that investigated vitamin A (n = 2/4) [39,67], found statistically significant lower serum values in patients versus controls. The majority of the studies that were not suitable for inclusion in the meta-analyses reported significantly lower vitamin E in patients versus controls (n = 3/4) [55,56,73]. ...
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Background Many chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) patients (35–68%) use nutritional supplements, while it is unclear whether deficiencies in vitamins and minerals contribute to symptoms in these patients. Objectives were (1) to determine vitamin and mineral status in CFS and FMS patients as compared to healthy controls; (2) to investigate the association between vitamin and mineral status and clinical parameters, including symptom severity and quality of life; and (3) to determine the effect of supplementation on clinical parameters. Methods The databases PubMed, EMBASE, Web of Knowledge, and PsycINFO were searched for eligible studies. Articles published from January 1st 1994 for CFS patients and 1990 for FMS patients till March 1st 2017 were included. Articles were included if the status of one or more vitamins or minerals were reported, or an intervention concerning vitamins or minerals was performed. Two reviewers independently extracted data and assessed the risk of bias. Results A total of 5 RCTs and 40 observational studies were included in the qualitative synthesis, of which 27 studies were included in the meta-analyses. Circulating concentrations of vitamin E were lower in patients compared to controls (pooled standardized mean difference (SMD): -1.57, 95%CI: -3.09, -0.05; p = .042). However, this difference was not present when restricting the analyses to the subgroup of studies with high quality scores. Poor study quality and a substantial heterogeneity in most studies was found. No vitamins or minerals have been repeatedly or consistently linked to clinical parameters. In addition, RCTs testing supplements containing these vitamins and/or minerals did not result in clinical improvements. Discussion Little evidence was found to support the hypothesis that vitamin and mineral deficiencies play a role in the pathophysiology of CFS and FMS, and that the use of supplements is effective in these patients. Registration Study methods were documented in an international prospective register of systematic reviews (PROSPERO) protocol, registration number:
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