Relying on a recent re-conceptualization of psychosis proneness as a personality trait, its relations with the Big Five traits were investigated in a meta-analytic study. This re-conceptualized trait – named Disintegration – is articulated as a broad, hierarchically organized, nine-faceted behavioral disposition. Disintegration is postulated to be a basic personality trait distinct from the Big Five traits. In accordance with this conceptualization, all the articles considered for this meta-analysis carry information on the relationship between Disintegration-like phenomena (referring to various aspects of symptomatology with prefix ‘schizo-’, both at the clinical and the sub-clinical level), and at least one Big Five trait. The benchmark for assuming distinctness of the trait Disintegration was .40, based on the meta-analytically derived correlations found among the Big Five traits. By computing inverse sampling variance weighted mean correlation coefficients under a random-effects assumption, the following associations were found between Disintegration and N, E, O, A, and C, respectively: .24, −.27, 0, −.19, and − 13. The differences in true correlations between the studies were substantial for each coefficient. Three variables were found to moderate Disintegration–personality correlations. The finding about the distinctness of Disintegration from other personality traits can have repercussions on the taxonomy of traits.