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The epilatory effects of trypsin on human skin, applied via lecithin reverse micelles
Abstract
A method of epilation using reverse micelles containing the proteolytic enzyme, trypsin, is described based on previous experimental findings on degenerative effects of proteolytic enzymes on hair follicles and follicle stem cells of guinea pigs and mice. The method involves rubbing of the preparation on wax epilated skin and leads to removal of hair from various skin regions, such as face, shoulders, arms and legs. The many advantages of this method renders it the method of choice for hair removal in cosmetology.
- Reversed micellar system was briefly introduced, and its application in separation of bioproducts, including proteins mainly, amino acid, antibiotics and nucleic acid was reviewed. Also, the latest advance of application in related fields with reversed micellar extraction was presented.
- Although the loss of scalp hair is distressing and many medical treatments focus on its restoration, the removal of body hair has been adopted since ancient times. Beauty standards, which r eflect the culture of each society, have been presenting the depilated body as absolutely desirable. Through the ages various methods of hair removal have been used depending on the requirements of the individuals. In recent years, Laser and Intense Pulse Light devices have been considered as the most promising solution for excess hair growth, without excluding the efficacy of other methods to induce satisfactory epilatory results. The enzyme-based hair removal method has received little recognition even though experimental and clinical data support its efficacy to provide long term or even permanent epilation. The present review presents these data and examines the likelihood of considering the aforementioned method as ideal.
- The preparation of lecithin organogels and their possible application as drug carriers was examined. Organogels have been prepared from solutions of soyabeen lecithin in the organic solvents isooctane, isopropyl palmitate and isopropyl myristate, by addition of a critical amount of water. The organanogels are transparent, with a high viscosity reaching 1000 Pas. Their water content varies from 0.15 to 1.15% v/v and depends on the nature of the organic solvent and the lecithin concentration, as shown by the phase diagram study. The capacity of the organogels to incorporate molecules with pharmacological action, such as xanthines, can be studied spectroscopically.
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