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Monoamine oxidase a dinucleotide repeat and amphetamine dependence
Abstract
Monoamine oxidase A (MAOA) represents a candidate biological marker of vulnerability to neuropsychiatric disorders. We examined the association between amphetamine dependence and dinucleotide (CA)(n) repeat polymorphism in the intron 2 of the MAOA gene in 27 unrelated amphetamine-dependent subjects and in 41 psychiatrically normal males without tabacco smoking, alcohol and coffee drinking habbits or any experience with using drugs of abuse. Genomic DNA was prepared from peripheral blood cells. Fragments of different lengths (8 alleles) were amplified by polymerase chain reaction (PCR) and visualised by electrophoresis in a 6% denaturating polyacrylamide gel. No statistically significant differences in allele frequencies were found between the amphetamine-dependent subjects and the controls.
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found.
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