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Figure S7

February 2008

License
CC BY 4.0

Authors:

David A. Hughes

University of Bristol

Tsinghua University

Torsten Schöneberg

University of Leipzig

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Visual haplotype graph of the TRPV5 locus from the SeattleSNPs data set. Each horizontal line is a haplotype and each vertical column is a SNP marked by its position in the TRPV5 sequence. Major alleles are marked in blue, and minor alleles are in yellow. All genotypes were used to infer the haplotypes. (3.64 MB TIF)

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Parallel Selection on TRPV6 in Human Populations

Article

February 2008

David A. Hughes · Kun Tang · Rainer Strotmann · Torsten Schöneberg · Mark Stoneking

Project

Nephrogenic Diabetes Insipidus

Project

GPCR and Diseases

Torsten Schöneberg

Project

Molecular mechanisms of Obesity

Torsten Schöneberg

Data

Full-text available

Figure S2

February 2008

Visual haplotype graph and network of the SeattleSNPs sequence data for the TRPV6 locus. A) A visual haplotype graph of the TRPV6 locus. Each horizontal line is an individual haplotype from a given individual, and each vertical column is a SNP marked by the position of that SNP in the sequence. The major alleles are in blue, while minor alleles are in yellow. B) A MJ network for the European and ... [Show full abstract] African SeattleSNP sequence data, with a box around the star-like portion of the network. Branch lengths for the haplotype nodes inside the box were artificially lengthened for illustration purposes. (3.08 MB TIF)

Data

Full-text available

Figure S5

February 2008

Haplotype frequencies of three non-synonymous polymorphisms used as tagging SNPs (rs4987657 (C157R), rs4987667 (M378V) and rs4987682 (M681T)) and genotyped in the CEPH Human Diversity panel and additionally in 31 Ethiopians, 51 Germans, 11 South African Bantu-speakers, and three hunter-gatherer groups from India (44 Koragas, 16 Mullukurunan, and 2 Mullukurumba). The key for inferred haplotypes is ... [Show full abstract] in the bottom right corner, with CGC corresponding to the ancestral haplotype and TAT to the derived haplotype. (4.14 MB TIF)

Data

Full-text available

Table S3

February 2008

World Haplotype Frequencies for C157R, M378V and M681T (0.03 MB DOC)

Data

Full-text available

Figure S4

February 2008

A topology graph of the TRPV6 protein illustrating the location of the three non-synonymous mutations, C157R, M378R and M681T and their relationship with putative important functional areas. (1.42 MB TIF)

Data

Full-text available

Figure S1

February 2008

A scatter plot of molecular Fst and lnRHap values for each of the 221 genes from the SeattleSNPs data set. Genes from the candidate region of chromosome 7q34, including the TRPV6 locus, are identified in the plot. (0.84 MB TIF)