Clinical experience with pipemidic acid in urinary tract infections (Japanese)

Abstract

The following results were obtained in urinary tract infections treated with pipemidic acid.
1. Clinical effects were excellent in 20 and good in 5 of 25 cases of acute urinary tract infections. The rate of effectiveness was 100%.
2. In 18 cases of chronic urinary tract infections having underlying diseases, 5 were excellent, 6 good, 4 moderate and 3 ineffective. The rate of effectiveness was 61. 1%.
3. Among 37 strains isolated from these urinary tract infections, Escherichia coil, Proteus mirabilis and Klebsiella sp. were inhibited by 0. 786. 25 μg of pipemidic acid per ml, and Enterobacter and Pseudomonas sp. by 6. 25-100 μg of the drug per ml. Compared to piromidic acid, nalidixic acid, ampicillin, cephalexin and gentamicin, pipemidic acid followed gentamicin in antibacterial potency.
4. No subjective side effects such as gastro-intestinal disturbances and rash were observed. GOT, GPT, BUN and creatinine levels in plasma did not rise in all cases, but decreases in the number of leucocytes were seen in 2 cases.