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Physics and Technique of Shock Wave Lithotripsy (SWL)

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  • Storz Medical

Abstract and Figures

Extracorporeal shock wave lithotripsy (SWL) is a gentle and noninvasive treatment ­procedure suitable for a wide range of kidney and ureteral stones. The technique makes use of extremely short transient (<1 μs) pressure pulses with pressure amplitudes up to 100 MPa (1,000 bars). Brittle stone material breaks into small pieces, whereas biological tissue passes shock waves without significant damage. Different shock wave generation principles (electrohydraulic, piezoelectric and electromagnetic) are presented, and basic shock wave parameters are discussed with regard to stone fragmentation and side effects. Modern lithotripsy devices utilize fluoroscopic and/or echographic imaging methods for stone localization and targeting. As with all sophisticated technologies, SWL requires comprehensive technical and anatomical skills to fully benefit from this exciting treatment method.
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301
J.J. Talati et al. (eds.), Urolithiasis,
DOI 10.1007/978-1-4471-4387-1_38, © Springer-Verlag London 2012
Introduction
On February 7, 1980, in Munich, Germany, for the rst time,
kidney stones were successfully fragmented within a patient’s
body by externally generated shock waves. The mechanical
energy of shock waves was transmitted through the intact
skin and concentrated on the stone without signi cant dam-
age of the tissue. The granular fragments were ushed out of
the body in natural way, eliminating the need for invasive
surgery. This date marks the beginning of a new era charac-
terized by application of acoustic energy for noninvasive
stone fragmentation and clearing [ 1, 2 ] . The revolutionary
nding was that shock waves may pass through living tissue
without signi cant injury or side effects while being simulta-
neously strong enough to fragmentize hard urinary stones.
The key reasons are the following: rst, elasticity of living
tissue, which may pass high transient pressures up to 100 MPa
(1,000 bars) and more; second, the liberation of transient
forces predominantly at acoustic interfaces with different
acoustic characteristics (acoustic impedance); and third, the
possibility to couple acoustic energy with low intensity into
the body and concentrate (focus) it on the region of interest,
the stone to be fragmented. This option allows the stone to be
exposed to suf cient shock wave power for fragmentation
while, simultaneously, all other tissue areas, which are passed
by the shock waves, are only affected insigni cantly.
To date, stones in the entire urinary tract are susceptible to
shock wave fragmentation only limited by the occasionally
huge amount of fragments to be passed via naturalis through
the urinary tract.
Abstract
Extracorporeal shock wave lithotripsy (SWL) is a gentle and noninvasive treatment
procedure suitable for a wide range of kidney and ureteral stones. The technique makes
use of extremely short transient (<1 m s) pressure pulses with pressure amplitudes up to
100 MPa (1,000 bars). Brittle stone material breaks into small pieces, whereas biological
tissue passes shock waves without signi cant damage. Different shock wave generation
principles (electrohydraulic, piezoelectric and electromagnetic) are presented, and basic
shock wave parameters are discussed with regard to stone fragmentation and side effects.
Modern lithotripsy devices utilize uoroscopic and/or echographic imaging methods for
stone localization and targeting. As with all sophisticated technologies, SWL requires
comprehensive technical and anatomical skills to fully bene t from this exciting treat-
ment method.
Keywords
Shock waves Extracorporeal lithotripsy Shock wave lithotripsy (SWL) Kidney stones
Electrohydraulic Piezoelectric Electromagnetic
Physics and Technique of Shock
Wave Lithotripsy (SWL)
Othmar J. Wess
3 8
O. J. Wess , Ph.D.
Storz Medical AG ,
Lohstampfestrasse 8 , Product Development, Taegerwilen,
Thurgau 8274 , Switzerland
e-mail: wess.othmar@storzmedical.com
Electronic supplementary material The online version of this chapter
(doi:
10.1007/978-1-4471-4387-1_38 ) contains supplementary material,
which is available to authorized users.
302 O.J. Wess
Nature of Shock Waves
Medically used shock waves are mechanical waves featuring
extremely high-pressure amplitudes in the range of
10–100 MPa (100–1,000 bars). They require an elastic
medium such as gas, uids, or soft tissue for propagation and
cannot be transmitted through vacuum. Shock waves appear
in nature as explosive noise generated by atmospheric lighting
or by detonation of explosive material. A typical pressure–
time pro le of a shock wave in water is shown in Fig. 38.1 .
Usually, medical shock waves are generated in water propa-
gating with approximately the speed of sound (1,500 m/s eq.
5,400 km/h). Due to the very high-pressure amplitudes, how-
ever, normal linear propagation conditions are exceeded so
that the highest pressure components travel slightly faster than
lower pressure components resulting in a steepening of the
pressure ascend of the wave as shown in Fig. 38.2 . Shock
waves in gaseous or uid mediums propagate as longitudinal
waves featuring particle movements in direction of propaga-
tion and reverse. As acoustic waves in general, shock waves
may be re ected, refracted, diffracted, or strayed when pass-
ing inhomogeneities with respect to acoustic features (acous-
tic impedance) of the medium. Shock waves may be focused
for energy concentration at speci c regions within human
bodies in order to expose selected target areas such as tissue
under treatment or kidney and ureteral stones.
Shock Wave Generation Methods
Electrohydraulic Shock Wave Generation
Shock waves may be generated by explosive processes, pri-
marily, expanding faster than the speed of sound in a particu-
lar medium such as water. Instead of explosive material, the
rst clinically used method was based on a high-energy elec-
trical discharge across a 1-mm spark gap ignited in a water
bath. A capacitor bank was charged by approximately 20,000
V (20 kV) and discharged across the electrode generating a
rapidly expanding plasma channel (spark). This plasma
channel pushed the surrounding water by pressures of more
than 100 MPa, which propagated into the medium. Figure 38.3
shows a series of high-speed photographs (frame rate 10
7
frames/s) with a lighting spark between two electrode tips
and a spherically expanding shock wave displayed with
shadow photographic technique. Electrical discharge gener-
ates shock waves in its physical meaning from the origin on
since the expanding velocity of the spark channel is slightly
higher than speed of sound. After a few millimeters of travel,
electrohydraulically generated shock waves are slowed down
to normal propagation velocity (approximately 1,500 m/s).
They may be re ected by acoustic mirrors and focused onto
the target position of the stone.
The primary shock wave generated by this method is a
spherically expanding wave, which propagates with the
speed of sound into the surrounding medium. The energy is
dissipated by expansion and needs to be concentrated on the
target stone for fragmentation. Concentration is done by
Shock Wave
time
tr
tw
tf
pressure
p+
p-
Fig. 38.1 Time pro le of a medical shock wave ( p + peak positive pres-
sure, p peak negative pressure, t r rise time, t w pulse width, t f fall time)
pressurepressurepressure
slower at low pressure
distance
distance
distance
steepening
steep flank
faster at high pressure
faster at high pressure
slower at low pressure
Fig. 38.2 Steepening of pressure rise. The pressure rise is compressed
to shorter rise times due to nonlinear propagation (faster with higher
pressure, slower with lower pressure). At high-pressure amplitudes,
shock fronts with steep rise develop with travel distance
30338 Physics and Technique of Shock Wave Lithotripsy (SWL)
re ection of the spherical wave at the surface of a hollow
ellipsoidal metal re ector (see Fig.
38.4 ).
The spark gap is placed at the rst focal spot of the ellip-
soid, and the primarily diverging wave is concentrated at the
second focal point in a distance. By cutting the ellipsoidal
structure at an intermediate level, this second focal spot can
be placed outside the metal structure to be aimed from out-
side the human body at the target stone within the body.
This pioneering type of shock wave generation and focus-
ing has been very successful and motivated engineers to fur-
ther develop shock wave techniques to overcome some of the
disadvantages of the electrohydraulic principle such as fre-
quent change of worn-out electrodes, uctuations of energy
output, and excessive noise.
A subgroup of electrohydraulic generators, called “elec-
troconductive shock wave generators,” makes use of a con-
ductive uid between the electrode tips in order to reduce
energy uctuations of sequential shocks.
Piezoelectric Shock Wave Generation
A more reproducible method of shock wave generation is
based on the piezo effect, which is widely used in ultrasound
diagnostic devices. Making use of the piezo effect, a large
number of piezo ceramic elements are activated simultane-
ously by applying an electrical tension of several kilovolts
(kV). According to the electrical excitation, the elements
expand, and the displacement of the surface generates a pres-
sure wave that propagates into the adjacent medium.
Piezoelectric elements can be arranged on the inner surface
of a spherical calotte to generate a spherical wave directed to
Fig. 38.3 HF photography of spark and shock wave generated in water
(10
7 frames/s). A spark is ignited between two electrode tips in a dis-
tance of approximately 1 mm. The plasma channel between the tips
expands with supersonic velocity and generates a spherical shock wave.
The shock wave separates from the plasma channel as soon as the
expansion velocity of the spark channel drops below the propagation
velocity in water (1,500 m/s)
F2F1
Fig. 38.4 Spherical shock waves generated in the rst focal spot F1 of
a semi-ellipsoid are partly concentrated on an area around F2 , the sec-
ond focal spot of the ellipsoidal structure. Part of the primary spherical
wave is radiated as dissipating wave without being focused
304 O.J. Wess
the center of the calotte. A piezoelectric shock wave genera-
tor is shown in Fig.
38.5 .
Whereas the electrohydraulically generated shock waves
originate from a tiny small point-shaped area between the
electrode tips with extremely high pressure and high energy
density, piezoelectrically generated shock waves are emitted
by a relatively large area with low energy density. In order to
provide suf cient energy for stone fragmentation within the
focal zone, a relatively large area of active piezo ceramic ele-
ments (several hundred square centimeters) is required. The
acoustic energy is generated as (non-shock wave) pressure
pulse and concentrated to a small area at the center of the
calotte. It becomes a shock wave by steepening on its travel
to the focus as shown in Fig. 38.2 .
Piezoelectric shock wave generators avoid the need for fre-
quent and costly change of electrodes as in the electrohydrau-
lic case and last several million shocks. Due to its complexity,
an exchange of the total shock wave head is more expensive.
Another advantage of piezoelectric generators is the reproduc-
ibility of each single shock and the precise control of the shock
wave parameters. The fragmentation power of piezo elements
is relatively low. It requires quite a large active area to yield
suf cient energy for stone fragmentation. There are attempts
to make use of a sandwich structure of two active areas: one at
the inner surface of the spherical calotte and another at the
outer surface. A slight delay of activation between the two
active spheres allows for a certain pulse shaping. By this tech-
nique, the size of the large calottes may be reduced to more
convenient dimensions. Nevertheless, the overall fragmenta-
tion power seems to be inferior to other techniques.
Electromagnetic Shock Wave Generation
The method of electromagnetic shock wave generation is
based on the physical principle of electromagnetic induction,
as used, for example, in loudspeakers. A strong pulse current
running through an electrical coil generates repelling forces
in a conducting membrane attached to the coil separated only
by a thin insulation foil. The conducting membrane is acti-
vated by eddy currents and pushed toward the adjacent
medium (water). Although the displacement of the membrane
measures only a fraction of a millimeter, the surrounding
water is compressed, and the according pressure distortion is
radiated as pressure wave into the medium (Fig. 38.6a, b ).
Two different con gurations are used in modern shock
wave lithotripsy (SWL) devices. The traditional electromag-
netic generator utilizes a at coil/membrane arrangement
Fig. 38.5 Piezo-calotte. Numerous piezo elements are arranged on a
spherical bowel and activated simultaneously to generate a self-
focussing spherical pulse wave
ab
Fig. 38.6 Flat coil/acoustic lens con fi guration . The electrical fl at coil ( a ) is covered by an insulation foil and a conducting membrane. Primary
plane acoustic waves are focused with the aid of an acoustic lens ( b )
30538 Physics and Technique of Shock Wave Lithotripsy (SWL)
that focuses a primarily plane pressure wave by aid of an
acoustical lens. The most advanced con guration has a cylin-
drical coil/membrane and a special rotational parabolic
re ector for focusing the primarily cylindrical pressure wave
to a precise focal spot (Fig. 38.7 ). As in the case of piezo-
electric generators, pressure waves generated by electromag-
netic principle turn into shock waves by steepening when
concentrated in the focal zone. The coil con guration pro-
vides a central opening for high-precision in-line integration
of X-ray or ultrasound localization devices.
The cylinder con guration does not require acoustical
lenses and offers widest apertures for gentle energy trans-
mission into the body and largest focal depth for treatment of
obese patients with extraordinary stone-to-skin distances.
Physical Characteristic of Shock Waves
Medically used shock wave devices may be characterized by
the type of shock wave generator and the spatial and tempo-
ral parameters of the shock wave eld. Aperture diameters,
focus distances, lateral and axial focus dimension, peak pres-
sure, and energy ux density are parameters affecting frag-
mentation power of a shock wave device as well as pain
sensation and risk of side effects [ 3– 6 ] .
Pressure
The shock wave eld is measured by taking time-pressure
records p ( t ) point by point, scanning a small hydrophone
through the three-dimensional shock wave eld. For each
spatial position, the peak pressure p + and the time pro le p ( t )
of the pressure curve are taken, including rise time and time
duration of each single pulse as shown in Fig. 38.1 . Shock
waves in medicine feature typically peak pressures of
10–100 MPa (100–1,000 bars) and sometimes more. Rise
times are in the range of <10–100 ns (nanosecond), depend-
ing on the type of generation. Time duration of the pressure
curve is approximately 0.5 m s (microsecond). Pulse length in
water/tissue is <1 mm. Each shock wave pulse is associated
with negative (tensile) wave components in the range of
10 % of the peak pressure p + .
−6 dB Focal Zone and 5 MPa Treatment Zone
Shock waves are coupled over a wide surface area into the
body and are concentrated (focused) to a treatment area with
intensi ed energy. The transmission pathway is protected
against high acoustic energy reducing side effects while,
simultaneously, effective treatment and possible side effects
are restricted to the region of interest, the treatment zone.
The therapeutic shock wave eld thus shows a central peak
of highest pressure p + and a continuously declining pressure
around as shown in Fig.
38.8 .
Taking the peak pressure p + as reference, a three-dimen-
sional zone may be de ned with pressure values being equal
or greater than ½ p + , the so-called −6-dB isobar. This zone is
usually taken as focal zone of a lithotripter. Please note that
Fig. 38.7 Cylinder source. The electrical cylinder coil is covered by an
insulation foil and a conducting membrane. The primary cylindrical wave
is re ected and focused by a rotational parabolic re ector. The hollow cen-
ter may be used for in-line uoroscopic or ultrasonic stone localization
Pressure
5 MPa
700650600550500450400350300250200150100
50
0
60 38 26 13 0
Axial [mm]
-13 -25 -38 -60
-10 -5 -6
Lateral [mm]
510
P+
P+
2(-6bB)
Fig. 38.8 Spatial pressure eld. The −6-dB zone is characterized by
50 % of the actual peak pressure p + . The area exceeding the pressure of
5 MPa may change with energy settings (different peak pressure)
306 O.J. Wess
this focus de nition does not re ect the dimensions of the
treatment area itself. It only relates, per physical de nition,
to the peak pressure. The peak pressure p + may vary between
different devices and settings signi cantly without affecting
the focal size. Therefore, the −6-dB focal zone simply re ects
the degree of energy concentration, but is neither a measure
to characterize the power of the shock wave eld nor the area
within which a shock wave eld may break stones.
To enable a comparison between different energy settings
and different devices, one may de ne the zone within a xed
isobar—of, for example, 5 MPa—as an area of therapeutic
(fragmentation) ef ciency. Even though the de nition of 5 MPa
seems to be arbitrary, it re ects the in uence of the energy set-
ting on the spatial dimensions of the effective zone (Fig. 38.9 ) .
Energy
Although p ( t ) being the primary parameter of a three-dimen-
sional shock wave eld, it does not correlate directly with the
fragmentation ef ciency, the main goal of a shock wave lith-
otripter. Shock wave energy (not only pressure) is needed to
break stones. The energy may be calculated for a given area
A by taking pressure curves p ( t ) within the area A and acous-
tical parameters of the propagation medium density ( r ) and
sound velocity ( c ), according to the formula:
The acoustical energy of a shock wave pulse is given in
millijoules (mJ). As a rule, several hundreds or thousands of
shock wave pulses are emitted per treatment, so that the total
emitted energy is yielded by multiplication with the number
of pulses.
Only that portion of the shock wave eld that hits the
stone will contribute to stone fragmentation. For character-
ization of different lithotripsy devices, a medium-sized stone
with a circular cross section with a diameter of 12 mm is
taken for reference by convention. The energy within this
cross-sectional area A gives a comparable number for the
fragmentation power of a lithotripter device.
Published data on the energy content of the −6-dB focal
zone are just physical parameters that do not characterize the
fragmentation power of a lithotripter (see chapter “-6dB
Focal Zone and 5 MPa Treatment Zone”).
Energy Flux Density (ED)
As previously mentioned, the therapeutic effect of shock
waves depends on how much shock wave energy is deposited
on the stone. The part that is missing the stone cannot con-
tribute to fragmentation. Therefore, not only energy values
()
2
/ ( )d energyEAcpttρ=
low
-6dB
5MP 5MPa 5MPa
-6dB -6dB
5MPa 5MPa
5MPa
50% = -6dB
50% = -6dB
50% = -6dB
medium
high
100
50
10
100
50
10
100
50
10
-6dB
5MPa
Fig. 38.9 A −6-dB focus zone versus 5-MPa treatment zone at differ-
ent energy settings. With increasing energy the treatment area, de ned
by the 5-MPa zone, increases accordingly whereas the dimensions of
the physical focus zone (−6 dB) may stay independent in size from the
selected energy setting. Nevertheless, the energy content (see text) of
the focus zone may vary signi fi cantly
30738 Physics and Technique of Shock Wave Lithotripsy (SWL)
are of interest but also the energy ux density (ED), a mea-
sure for the spatial energy concentration (energy E /area A ):
The energy ux density (ED) is given in millijoules per
square millimeter (mJ/mm
2 ).
The total amount of shock wave energy delivered to the
stone may be calculated by integration of the energy ux
density over the cross-sectional area of the stone.
The parameters previously described are usually suf cient
to characterize a shock wave eld for medical applications.
Shock wave devices that work with different generation
principles can differ in relation to the listed parameters. The
“quality” of the shock waves used in the treatment zone,
however, seems to be independent from the generation prin-
ciple. In other words, the measurement of the above param-
eters in the treatment zone does not allow any fundamental
conclusions to be drawn about the type of generation.
Electrohydraulically generated shock waves are not better or
worse than piezoelectrically or electromagnetically gener-
ated shock waves, although secondary parameters such as
accuracy of repetition, dose control, energy range, and oper-
ating costs for consumables may differ signi cantly.
Note that the parameters discussed previously Ohysical
Characteristics of Shock Waves are usually measured in
water. Due to the inhomogeneities in living tissue, however,
deviations from the straight propagation of shock waves
occur. With increasing depth in the body, the peak pressure
as well as ED values may signi cantly be reduced by realis-
tic anatomical conditions. Accordingly, focal dimensions
(−6-dB focus) may be signi cantly (up to 10 mm) expanded
depending on individual anatomical conditions [ 7 ] .
Medical Shock Wave Effects
Wanted Effects
Although shock waves feature extremely high pressures for
very short time duration, elasticity of living tissue allows for
transmission of high-pressure waves usually without
signi cant lesions. Shock wave-speci c forces are generated
at acoustic interfaces characterized by different acoustic
impedances (density r × propagation velocity c ). Since
water, where shock waves are usually generated, and soft tis-
sue feature similar acoustic impedances, shock wave forces
at the water/skin interfaces are small as well as at interfaces
between different soft tissues. At the interface between kid-
ney and stone, however, a signi cant impedance mismatch
creates strong forces by incident and re ected waves.
Fragmentation forces are generated at front and rear surface
of the stone when shock waves are transmitted and re ected
(Fig. 38.10a ). Erosion and spallation (Hopkinson effect) at
rear surface are observed (Fig.
38.10b ). There are different
additional fragmentation effects discussed such as squeez-
ing, fatigue by development of micro rupture lines, and oth-
ers including cavitation effects [ 8– 12 ] .
Cavitation is an important mechanism for stone fragmen-
tation. The tensile trail of shock waves tears open small cavi-
tation bubbles (Fig. 38.11 ). They may collapse by generating
a needlelike water jet when close to an acoustic interface
such as the stone surface. Those microjets are directed toward
the interface and may have the velocity of gun bullets of sev-
eral hundred m/s. The impact of these high-velocity micro-
jets contributes to erosion and is an important factor of stone
fragmentation.
Shock waves were introduced into medicine primarily for
noninvasive stone fragmentation. Meanwhile, however,
another important shock wave effect was discovered. Shock
wave stimulation of soft tissue results in regeneration and
improved blood supply and is widely used in a variety of
medical indications, mainly for treatment of chronic pain
diseases such as chronic pelvic pain syndrome (CPPS),
orthopedic pain diseases, and cardiology.
Unwanted Effects
As with any medical method, there are always side effects
(Paracelsus 1493–1541). Fortunately, shock waves are asso-
ciated with predominately bene cial features, but certain
unwanted side effects may occur. The stone-breaking power
of shock waves may cause tissue lesions mainly by cavita-
tion effects. The mentioned microjets may punch small ves-
sels and cause microbleedings, which may, rarely, result in
signi cant hematomas (Fig. 38.12 ). Administration of anti-
coagulation drugs has to be thoroughly controlled.
Since shock waves may affect the nervous system as well
as the cardiac excitation system, according effects such as
cardiac interference are possible risks. Due to a major mis-
match of acoustic impedances of soft tissue and gas-contain-
ing organs (lungs, intestine), signi cant forces may be
generated at interfaces to such organs. Therefore, these organs
should be kept free from shock wave exposure, at least from
the high energetic focal area. Bony structures exposed to
shock waves will distort shock wave propagation, avoiding
successful stone fragmentation. Last, but not least, shock
wave application for stone treatment causes pain. Depending
on the shock wave generation methods and treatment strategy,
pain killers or even general anesthesia may be appropriate.
How to Apply Shock Waves
As a general rule, the mentioned bene ts (stone fragmenta-
tion, less invasiveness etc.) have to be balanced against rare,
()
2
/ 1/ ( )d ED energy flux densityEA c p t tρ==
308 O.J. Wess
a
b
Fig. 38.10 ( a ) An arti cial stone of plaster (3 × 3 × 1.5 cm) is hit from
the right by a focused shock wave. The front surface ( right ) is eroded
and a crater develops. The whole stone is shattered and pieces break off
the corner. ( b ) Sequential shock waves (incident from right ) hit a 1-cm
cube of plaster. At the rear surface ( left ), spallation due to the Hopkinson
effect is seen, and pieces are expelled from the front surface until the
stone breaks completely
Fig. 38.11 The shock wave at top propagated from the bottom to top
(approximately 75 mm) within 50 m s and generated a cloud of cavita-
tion bubbles. The time history of bubble expansion and the following
collapse can be deduced from their spatial location. Bubbles immedi-
ately behind the shock front were just generated and growing. Bubbles
in the middle have been generated approximately 30 m s before when the
shock front passed this area. They reached maximal diameters and start
to collapse. At the lower third, they collapsed completely after 40–50 m s
and create spherically expanding secondary shock waves ( circles at
lower part of the image )
30938 Physics and Technique of Shock Wave Lithotripsy (SWL)
but possible side effects (tissue lesions, pain, hematoma etc.).
Two aspects have to be considered: (1) skills and diligence of
the operating personnel and (2) technical concepts and
con gurations of the shock wave sources.
First: The operator needs medical training for exact diag-
nosis of stone diseases and in-depth anatomical knowledge
to proper selection of the appropriate shock wave passage to
the stone and optimal patient positioning. It does not suf ce
to see the stone at the predetermined position by the local-
ization device if the transmission pathway through the tis-
sue is obstructed by bony or gaseous structures. If necessary,
the position of the patient has to be corrected repeatedly.
Since with extracorporeal lithotripsy shock wave energy is
generated outside the body, it needs to be transmitted to the
body without signi cant losses. The coupling area of a
shock wave head at the surface of the patient may include
air bubbles that will signi cantly reduce effective energy
coupling even if the bubbles seem to be insigni cantly
small. Great care is required to perform the coupling pro-
cess to satisfaction. These skills and suf cient experience of
the operator are mandatory. They were not always given in
the past and could cause low success rates not to be accused
to the device.
Second: From a technical point of view, the con guration
of the shock wave eld can be optimized to provide suf cient
amount of acoustic energy for stone fragmentation prefera-
bly only at the location of the stone and to keep the energy
exposure low anywhere else. The same rationale holds true
also for the area where bene cial (fragmentation) as well as
impairing cavitational effects may occur. The technical
solution is a shock wave head with a wide aperture for soft
and pain-free energy transmission and an appropriately
sized treatment zone, not too big to affect tissue excessively
around the stone and not too small to make positioning
dif cult. In spite of the differences between treatment zone
and focal zone (see previous), the ability of a device to focus
precisely is preferred if stone localization is frequently
checked. There is no consensus about the optimal size of the
treatment zone. Larger treatment zones may facilitate posi-
tioning but lack generous power reserves for excessively
hard stones when needed. Additionally, even at lower energy
settings, an increased tissue area is exposed to signi cant
shock wave energy far beyond the dimensions of the stone
treated. Whenever the power setting of a device is suf cient
for stone fragmentation, a certain risk, usually small, to gen-
erate tissue lesions cannot be excluded. Single shock wave
devices such as the MODULITH® SLX-F2 ( STORZ
MEDICAL), therefore, offer switchable focus capabilities
for an individually matched treatment strategy regarding
size and hardness of stones, localization, pain sensation, and
other parameters.
Device Concepts
Routine lithotripsy procedures demand for ergonomic device
concepts consisting of a shock wave generator, localization
modality such as ultrasound and/or X-ray, a patient support,
and positioning structure. Ultrasound localization provides
real-time control of stone location and progress of fragmen-
tation but requires according skills of the operator that are
not common in all countries. Fluoroscopic targeting seems to
be preferred more widely. Both localization modalities may
be applied in-line, out of the center of the shock wave source,
Fig. 38.12 Collapse of a cavitation bubble (schematic) close to an
acoustic interface (stone surface). Due to asymmetric streaming condi-
tions at the interface, an asymmetrical collapse occurs and generates a
microjet directed toward the interface. Microjets featuring velocities up
to several hundred m/s affect the interface and contribute to erosion and
stone fragmentation as well as tissue lesions
310 O.J. Wess
meaning coaxially with the direction of shock wave propaga-
tion, or off-line, meaning outside the therapy head. The in-
line con guration enables direct control of the coupling area
as well as the transmission area within the body allowing for
optimized treatment selection with respect to coupling direc-
tion and quality of energy transmission (Fig. 38.13 ).
For busy stone centers with large numbers of SWL patients,
dedicated lithotripsy workstations, just for lithotripsy pur-
poses, may be the best choice. Today’s multifunctional work-
stations include highly exible patient support and positioning
systems as well as high-quality uoroscopic imaging and
localization devices to enable endourologic and percutaneous
stone treatment procedures on the same device. A modern
multifunctional workstation is shown in Fig. 38.14 .
Conclusion
Extracorporeal shock wave lithotripsy is an ef cient and
gentle stone treatment method less invasive than percuta-
neous or transureteral procedures. Although SWL tech-
niques seem to feature low risks and simple operation,
excellent SWL results require special operational skills as
well as technical and anatomical knowledge in order to
gain full bene fi t of modern lithotripsy technology.
Acknowledgement The author worked from 1979 till 1987 in the
eld of extracorporeal shock wave lithotripsy for Dornier Medizintechnik
GmbH, Münich, Germany, and from 1988 till 2009 for STORZ
MEDICAL AG, Taegerwilen, Switzerland. Since 2010, he is consultant
for STORZ MEDICAL AG.
Fig. 38.13 In-line localization. Fluoroscopy or ultrasound localization arranged in-line with shock wave propagation enables precise control of
stone position and quality of shock wave passage
Fig. 38.14 Multifunctional urological workstation for lithotripsy,
endourology, and percutaneous nephrolithotomy ( PCNL )
31138 Physics and Technique of Shock Wave Lithotripsy (SWL)
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... Originally, shock waves were used only to break stones in the kidneys and urinary tract, while recently they are used in orthopedic therapy or to treat patients with Alzheimer's disease. For example, for the first time in 1981 in the USA, shock wave pressure was used in medicine to break stones in the urinary tract [8]. The device where the shock waves are produced and enables their focusing is called a lithotripter. ...
Article
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Among the well-known methods in medicine is the application of mechanical waves, as well as ultrasound and shock wave methods. It is known that the characteristics of mechanical waves are determined by amplitude and frequency. If the frequency of the wave is above 20000Hz, then it cannot be heard by the human ear. These waves are called ultrasounds. The basic principle of ultrasound application in medicine is that different tissues or foreign bodies (eg. stones) reflect ultrasound waves differently. In ultrasonography, reflected ultrasound waves are recorded by transducers and translated into a recorded image. On the other hand, if the mechanical wave propagates through a medium with a speed greater than the speed of sound propagated through that medium, then we have the shock wave. In this case, the waves produce an instantaneous increase in pressure or energy for very short intervals of time. These energetic impulses are usually applied in medicine to break kidney stones or urinary channels stones. The basic principle of the application is to focus the energy impulse of the wave on the places where the stones are found and hit them. During shock, the stones are broken and these can come out through the urinary channels. Such a method is called lithotripsy, while the device is called a lithotripter. In this contribution, we modelled the shock waves according to the FE method, while the simulation was done in the ANSYS application.
... The peak pressure varies in different equipment and machine settings, and the À6 dB zone is defined for easy comparison. 37 The À6 dB point represents the location where the peak positive pressure of the shock wave drops to 50% of its initial value at the focal point. 38 At P in ¼ 1 bar, the À6 dB zone is limited to a distance of approximately 8.5 mm, and this distance increases to around 10 mm at P in of 4 bar. ...
Article
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Radial extracorporeal shockwave therapy (rESWT) is a noninvasive medical technique that treats a range of musculoskeletal conditions. To understand its biological effects and develop personalized treatment plans, it is crucial to fully characterize the acoustic field that rESWT generates. This study presents a quantitative assessment of rESWT's acoustic field, achieved through experiments and simulations. The study measures the acoustic fields using a needle-type hydrophone under different machine settings and establishes and calibrates a computational model based on the experimental measurements. The study also determines the spatial distributions of peak pressure and energy flux density for different driving pressures. High-speed photography is used to visualize cavitation bubbles, which correspond to the negative pressure distribution. The study finds that the axial pressure distribution is similar to the acoustic radiation from an oscillating circular piston, whereas the radial pressure distribution cannot be described by acoustic radiation. Furthermore, the study develops a machine learning model that predicts positive pressure distributions for continuous driving pressure. Overall, this study expands our understanding of the acoustic fields generated by rESWT and provides quantitative information to explore underlying biological mechanisms and determine personalized treatment approaches.
... ESWL was first invented in the 1970s and introduced as a novel method for management of renal tract stones in the 1980s, gaining widespread recognition and utility as a first-line treatment option [32]. Over the last 40 years, better technology and more advanced equipment have been developed, yet there has been little modification to the way the shock waves are generated or delivered to its intended target. ...
Chapter
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This chapter explores the diagnosis as well as various methods for stone clearance and recent advancements in each of the avenues, so as to provide the avid reader an understanding of the basis of each intervention and new exciting technology that lay on the horizon. Each section is further subdivided such that it would be easy for readers to search and look up relevant information at a glance without having to read through the entirety of the chapter. Firstly, diagnosis of renal calculi is explored, as renal tract pain can mimic a variety of abdomino-pelvic conditions and cause the same constellation of symptoms. Evidence based investigation modalities are discussed. Subsequently, management of renal tract calculi are divided into conservative management with analgesia and medical expulsion therapy, extracorporeal shock wave lithotripsy, ureteropyeloscopy and laser lithotripsy, as well as percutaneous nephrolithotomy. The different stone size, composition, location and patient factors have all contributed to the different surgical options as detailed above. Each section end with a discussion of new and exciting innovations in each of the areas that may lead to even more efficient and safer interventions for the Urology of the future.
... Currently, three generating technologies (EH, EM, PE) for converting electrical energy into pressure waves are used for ESWT [18]. Based on the reflector design, intended use, energy range, and other parameters, it is difficult to compare technologies or manufacturers. ...
Article
Full-text available
The potential beneficial regenerative and stimulatory extracorporeal shock wave therapy (ESWT) applications to the central nervous system have garnered interest in recent years. Treatment zones for these indications are acoustically shielded by bones, which heavily impact generated sound fields. We present the results of high-resolution tissue-realistic simulations, comparing the viability of different ESWT applicators in their use for transcranial applications. The performances of electrohydraulic, electromagnetic, and piezoelectric transducers for key reflector geometries are compared. Based on density information obtained from CT imaging of the head, we utilized the non-linear wave propagation toolset Matlab k-Wave to obtain spatial therapeutic sound field geometries and waveforms. In order to understand the reliability of results on the appropriate modeling of the skull, three different bone attenuation models were compared. We find that all currently clinically ESWT applicator technologies show significant retention of peak pressures and energies past the bone barrier. Electromagnetic transducers maintain a significantly higher energy flux density compared to other technologies while low focusing strength piezoelectric applicators have the weakest transmissions. Attenuation estimates provide insights into sound field degradation and energy losses, indicating that effective transcranial therapies can readily be attained with current applicators. Furthermore, the presented approach will allow for future targeted in silico development and the design of applicators and therapy plans to ultimately improve therapeutic outcomes.
... Shock waves are sharp discontinuities, characterised by a peak positive pressure (between 30 and 150 MPa) with a phase duration between 0.5 and 3 µs, followed by a tensile wave with a peak negative pressure that drops to 20 MPa with a duration of 2-20 µs [12]. This decrease in pressure causes the cavitation phenomenon. ...
Article
Full-text available
Sonodynamic therapy (SDT) is a noninvasive method for cancer treatment based on selective activation of a sonosensitiser by ultrasound (US), which results in the generation of reactive oxygen species (ROS) and cancer cell death. SDT uses a similar approach to photodynamic therapy (PDT), but can overcome the main drawback of PDT, i.e., poor tissue penetration of light. This research work investigated the anticancer effect of SDT on various two- (2D) and three-dimensional (3D) in vitro tumour models, using PDT as a reference treatment. Sonodynamic experiments were performed with pulsed US, specifically with shock waves (SW) and the prodrug 5-aminolevulinic acid (Ala), which is converted—at the mitochondrial level—into the sonosensitiser protoporphyrin IX (PPIX). SW-mediated PPIX sonodynamic activation resulted in a significant decrease in cell proliferation, especially on human fibrosarcoma (HT-1080) cells, where PPIX accumulation was higher compared to human melanoma (A2058) and neuroblastoma (SH-SY5 Y) cells. Moreover, SW-mediated SDT showed significant ROS generation, cell line-dependent in its amount, probably due to differences in Ala-induced PPIX synthesis. In all cancer cell lines, apoptosis was highlighted as the main cancer cell death pathway determined by SW-mediated SDT, along with significant cytochrome c release, and a consequent increase in DNA damage. The efficacy of SDT with SW and Ala in halting cancer cell proliferation was also confirmed in 3D cancer spheroids. The present study suggests that SW-mediated SDT is a valuable approach to slow down tumour proliferation, thus opening an innovative scenario in cancer treatment.
... Additional corresponding geometric sound field parameters which may be readily obtained indirectly through the listed manufacturers include the −6 dB and the 5 MPa zones. These correspond to focal volumes of peak pressures exceeding 50% of the maximum peak pressure and those exceeding the 5 MPa threshold, respectively [22]. It is noteworthy that all these geometric descriptors only provide summative (for energies) or maximal (for pressures) values and none of the waveforms (time evolution of the pressure) themselves. ...
Article
Full-text available
In vitro investigations, which comprise the bulk of research efforts geared at identifying an underlying biomechanical mechanism for extracorporeal shock wave therapy (ESWT), are commonly hampered by inadequate descriptions of the underlying therapeutic acoustical pressure waves. We demonstrate the necessity of in-situ sound pressure measurements inside the treated samples considering the significant differences associated with available applicator technologies and cell containment. A statistical analysis of pulse-to-pulse variability in an electrohydraulic applicator yields a recommendation for a minimal pulse number of n = 300 for cell pallets and suspensions to achieve reproducible treatments. Non-linear absorption behavior of sample holders and boundary effects are shown for transient peak pressures and applied energies and may serve as a guide when in-situ measurements are not available or can be used as a controllable experimental design factor. For the use in microbiological investigations of ESWT we provide actionable identification of common problems in describing physical shockwave parameters and improving experimental setups by; (1) promoting in-situ sound field measurements, (2) statistical evaluation of applicator variability, and (3) extrapolation of treatment parameters based on focal and treatment volumes.
... [19] Lithotripsy can use many types of energy, including ultrasonic, electro-hydraulic, piezoelectricity, and electromagnetic waves. [20] e holmium laser, which was first used in urology more than 30 years ago, is a small contact lithotrite (200-1000 mm) that effectively breaks up urinary stones with minimal stone retropulsion or subsequent collateral damage to the surrounding tissue. [6] is technique has several important advantages: Suitability for lithotrity; flexibility due to the structures of thin and soft fibers, reduced energy loss; and favorable safety with minimal tissue damage due to the relatively high absorption coefficient of the holmium laser in water. ...
Article
Full-text available
This case report describes a young female patient with a history of surgery to treat choledochal cyst since childhood who was admitted to our hospital with cholangitis. An imaging examination revealed giant stones that almost completely filled the intrahepatic biliary tract. The patient underwent percutaneous transhepatic lithotripsy using a holmium laser. After the lithotripsy, cholangiography showed no residual stones. The patient displayed clinical improvement and was discharged after 14 days in the hospital. This case serves as a reminder of gallstone complications that can occur subsequent to choledochal cyst surgery with biliary-enteric anastomosis and emphasizes many outstanding advantages of percutaneous transhepatic lithotripsy compared with classical surgery.
Article
Introduction. Recently, the prevalence of urolithiasis in pediatric population has been steadily increasing, but up to now there is no any universal technique for treating urolithiasis in children. Among many options for surgical treatment of upper urinary tract urolithiasis, remote lithotripsy occupies one of the leading positions. Purpose. To highlight principles and mechanisms of remote lithotripsy, its indications and contraindications using a systemic review of modern literature for the period of 2001–2021. Material and methods . A systematic review of foreign and domestic literature for the period of 2001–2021 was made. Key words for the search were : urinary stone disease, urolithiasis, remote (shock wave) nephrolithotripsy, fragmentation of stones. 64 full-text articles out of 1339 literature sources are included in the review. Results. On analyzing the obtained results, it has been found out that one session of remote shock wave lithotripsy is effective in more than 90% of cases, if calculus dimensions are less than 20 mm and its density is less than 1200–1500 Hounsfield units. Location of the calculus also plays a role. Conclusion. Remote shock wave lithotripsy is a reasonable option due to a number of facts, the main of which are non-invasive approach and a large percentage of favorable outcomes associated with cleaning the upper urinary tract from stones.
Chapter
Paper reports the result of an analogue experiment of developing a minimally invasive therapeutic device. High pressures were created at a very localized spot by focusing shock waves reflected from a truncated ellipsoidal reflector on a miniature size. A Q-switched Ho: YAG laser beam is repeatedly generated at a focal point inside the reflector. The resulting peak pressure achieved at 80 MPa which is high enough to exhibit tissue damage at the very localized spot. An analogue experiment was successfully performed on a slab of fresh potato. It was clarified that the damaged area in the potato model and the laser energy had a positive correlation. Hence convincingly this system has a promising clinical application to repeatedly damage soft tissues very precisely and minimally invasive fashion.KeywordsUnderwater shock waveQ-switched Ho: YAG laserMiniaturized focused shock wave generator
Article
A significant proportion of lesions treated with transcatheter interventions in the coronary and peripheral vascular beds exhibit moderate to severe calcific plaques known to portend lower procedural success rates, increased peri-procedural adverse events, and unfavorable clinical outcomes compared with noncalcific plaques. Adapted from lithotripsy technology used for treatment of ureterorenal calculi, intravascular lithotripsy (IVL) is a novel technique for the treatment of severely calcific plaque lesions that uses acoustic shockwaves in a balloon-based delivery system. Shockwaves induce calcium fractures, which facilitate stent expansion and luminal gain. In this review, the authors summarize the physics, preclinical and clinical data on IVL use in the coronary and peripheral vasculature, and future directions of IVL in transcatheter cardiovascular therapies.
Article
Focused shock waves administered during extracorporeal shock-wave lithotripsy (ESWL) cause stone fragmentation. The process of stone fragmentation is described in terms of a dynamic fracture process. As is characteristic of all brittle materials, fragmentation requires nucleation, growth and coalescence of flaws, caused by a tensile or shear stress. The mechanisms, operative in the stone, inducing these stresses have been identified as spall and compression-induced tensile microcracks, nucleating at pre-existing flaws. These mechanisms are driven by the lithotripter-generated shock wave and possibly also by cavitation effects in the surrounding fluid. In this paper, the spall mechanism has been analysed, using a cohesive-zone model for the material. The influence of shock wave parameters, and physical properties of stone, on stone comminution is described. The analysis suggests a potential means to exploit the difference between the stone and tissue physical properties, so as to make stone comminution more effective, without increasing tissue damage.
Article
High-energy shock waves were used to disintegrate kidney stones in dogs and man. In 96% of 60 dogs with surgically implanted renal pelvic stones, the fragments were discharged in the urine. The same effect was achieved in 20 out of 21 patients with renal pelvic stones. In the twenty-first patient, a staghorn calculus was broken up to facilitate surgical removal. 2 patients with upper ureteric stones also received shock waves, but their stones had to be removed surgically; in 1 of these the stone had been embedded in the ureteric wall by connective tissue. The procedure can in many cases be done under epidural instead of general anaesthesia. Side-effects consisted of slight haematuria and, occasionally, of easily treatable ureteric colic. They were probably due to passage of fragments down the ureter. Disintergration of kidney stones by shock waves seems to be a promising form of treatment that reduces the need for surgery.
Article
Two projects in our laboratory highlight some recent developments in shockwave lithotripsy (SWL) physics research. In the first project, we developed a prototype of a piezoelectric annular array (PEAA) shockwave generator that can be retrofitted on a Dornier HM-3 lithotripter for active control of cavitation during SWL. The PEAA generator, operating at 15 kV, produces a peak positive pressure of approximately 8 MPa with a -6-dB beam diameter of 5 mm. The shockwave generated by the PEAA was used to control and force the collapse of cavitation bubbles induced by a laboratory electrohydraulic shockwave lithotripter with a truncated HM-3 reflector. With optimal time delay between the lithotripter pulse and the PEAA-generated shockwave, the collapse of cavitation bubbles near the stone surface could be intensified, and the resultant stone fragmentation in vitro could be significantly improved. In the second project, high-speed shadowgraph imaging was used to visualize the dynamics of lithotripter-induced bubble oscillation in a vascular phantom. Compared with the free bubble oscillation in water, the expansion of cavitation bubble(s) produced in silicone tubes and a 200-microm cellulose hollow fiber by either a Nortech EHL or a Dornier XL-1 lithotripter was found to be significantly constrained. Rupture of the cellulose hollow fiber was observed consistently after about 20 shocks from the XL-1 lithotripter at an output voltage of 20 kV. These results confirm experimentally that SWL-induced cavitation in vivo can be significantly constrained by the surrounding tissue, and large intraluminal bubble expansions could cause rupture of capillaries and small blood vessels.
Article
We present our experience with extracorporeal shock wave lithotripsy (ESWL) and the new therapeutic aspects it has generated. The current state of technology also will be discussed.
Article
The rarefaction shock wave produced by an extracorporeal shockwave lithotripter can result in liquid failure at numerous discrete sites near the second focus. When the liquid fails, vapor-filled cavities can grow to relatively large sizes and subsequently collapse with enormous violence. This phenomenon, called acoustic cavitation, has been shown to cause severe erosion in materials exposed to cavitation fields. It is proposed in this paper that ESWL devices generate acoustic cavitation in vivo and that the high speed liquid microjets produced during cavitation bubble collapse play an important role in renal calculi disintegration.
Article
Computed tomography (CT) was performed in 50 patients before and after extracorporeal shock wave lithotripsy (ESWL) to determine the effects of ESWL on the kidney and perinephric tissues. Bilateral treatments were performed in three patients. Post-ESWL scans demonstrated subcapsular hematomas in eight (15%) patients (two large, six small, none symptomatic) and intrarenal hematomas in two (4%) patients. In three (6%) patients small subcapsular fluid collections of uncertain cause were seen. Treated kidneys showed a statistically significant mean increase in size (9%) after ESWL, as measured at the axial level of the major stone fragment. Perinephric soft-tissue stranding and fascial thickening were seen in 37 (70%) of 53 treated renal fossae, with the changes ranging from mild to severe. The authors conclude that while most patients undergoing ESWL will show some posttreatment abnormality on CT scans, the procedure appears to be associated with a low frequency of serious renal trauma.
Article
The acute effects of extracorporeal shock-wave lithotripsy (ESWL) on morphology and function of the kidney were evaluated by excretory urography, quantitative radionuclide renography (QRR), and magnetic resonance imaging (MRI) in 33 consecutive patients. Excretory urograms demonstrated an enlarged kidney in seven (18%) of 41 treatments and partial or complete obstruction of the ureter by stone fragments after 15 (37%) of 41 treatments. Total effective renal plasma flow (ERPF) was not changed after ESWL, but the percentage ERPF of the treated kidney was decreased by more than 5% in 10 (30%) of 33 cases. QRR images showed partial parenchymal obstruction in 10 (25%) of 41 treated kidneys and total parenchymal obstruction in 9 (22%). MRI disclosed one or more of the following abnormalities in 24 (63%) of 38 treated kidneys: (1) loss of corticomedullary differentiation, (2) perirenal fluid, (3) subcapsular hematoma, (4) hemorrhage into a renal cyst, and (5) unexplained abnormalities. Treated kidneys were normal by all three imaging methods in 26% and abnormal by one or more tests in 74% of cases. The morphologic and functional changes are attributed to renal contusion resulting in edema and extravasation of urine and blood into the interstitial, subcapsular, and perirenal spaces.
Article
High-energy shock waves were used to disintegrate kidney stones in dogs and man. In 96% of 60 dogs with surgically implanted renal pelvic stones, the fragments were discharged in the urine. The same effect was achieved in 20 out of 21 patients with renal pelvic stones. In the twenty-first patient, a staghorn calculus was broken up to facilitate surgical removal. 2 patients with upper ureteric stones also received shock waves, but their stones had to be removed surgically; in 1 of these the stone had been embedded in the ureteric wall by connective tissue. The procedure can in many cases be done under epidural instead of general anaesthesia. Side-effects consisted of slight haematuria and, occasionally, of easily treatable ureteric colic. They were probably due to passage of fragments down the ureter. Disintergration of kidney stones by shock waves seems to be a promising form of treatment that reduces the need for surgery.
Article
Focused shock waves administered during extracorporeal shock-wave lithotripsy (ESWL) cause stone fragmentation. The process of stone fragmentation is described in terms of a dynamic fracture process. As is characteristic of all brittle materials, fragmentation requires nucleation, growth and coalescence of flaws, caused by a tensile or shear stress. The mechanisms, operative in the stone, inducing these stresses have been identified as spall and compression-induced tensile microcracks, nucleating at pre-existing flaws. These mechanisms are driven by the lithotripter-generated shock wave and possibly also by cavitation effects in the surrounding fluid. In this paper, the spall mechanism has been analysed, using a cohesive-zone model for the material. The influence of shock wave parameters, and physical properties of stone, on stone comminution is described. The analysis suggests a potential means to exploit the difference between the stone and tissue physical properties, so as to make stone comminution more effective, without increasing tissue damage.
Article
Currently, several mechanisms of kidney stone fragmentation in extracorporal shockwave lithotripsy (ESWL) are under discussion. As a new mechanism, the circumferential quasistatic compression or "squeezing" by evanescent waves in the stone has been introduced. In fragmentation experiments with self-focussing electromagnetic shock-wave generators with focal diameters comparable to or larger than the stone diameter, we observed first cleavage surfaces either parallel or perpendicular to the wave propagation direction. This is in agreement with the expectation of the "squeezing" mechanism. Because, for positive pulse pressures below 35 MPa and stones with radii of 15 mm or smaller, cleavage into only two fragments was observed, we developed a quantitative model of binary fragmentation by "quasistatic squeezing." This model predicts the ratio of the number of pulses for the fragmentation to 2-mm size and of the number of pulses required for the first cleavage into two parts. This "fragmentation-ratio" depends linearly alone on the stone radius and on the final size of the fragments. The experimental results for spherical artificial stones of 5 mm, 12 mm and 15 mm diameter at a pulse pressure of 11 MPa are in good agreement with the theoretical prediction. Thus, binary fragmentation by quasistatic squeezing in ESWL as a new efficient fragmentation mechanism is also quantitatively verified.