Article

A comparison of the effect of regular Eno® and placebo on intragastric pH

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Abstract

Background: Eno® (sodium bicarbonate + citric acid, active moiety sodium citrate) is a non-prescription antacid that is used for relief of heartburn, sour stomach, and acid indigestion. Objective: The primary objective of this trial was to determine the time required for regular Eno® to induce a significant acid neutralization effect compared to placebo. Methods: We conducted a randomized, open, crossover study in healthy fasting subjects. Subjects received either regular Eno or placebo (water), with a two-day washout between crossover periods. Changes in gastric pH were measured with a nasogastric pH probe and recorded using a Mark I Gastrograph. Results: Twenty-four subjects completed the study. Eno showed a significant increase in pH within 6 seconds compared to 18 seconds for placebo. Conclusions: Our study suggests that Eno can create a significantly greater and faster neutralization effect when compared to placebo in healthy, fasting individuals. Eno was well tolerated in this study.

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... 50 Effervescent powder forms of sodium bicarbonate antacids can start neutralizing acid in a few seconds. 51 Antacids have a duration of action of 20 to 60 minutes when ingested on an empty stomach. After a meal, approximately 45 mEq/ hour HCl is secreted. ...
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