Black Seed is a long known nutraceutical that possesses natural healing properties against many ailments and has been used for several thousand years. The seed is obtained from the annual flowering plant of family Ranunculaceae with botanical name of Nigella sativa. Black Seed is aromatic, bitter in taste, rich in nutritional and therapeutic values and contains carbohydrates, fats, proteins and minerals in balanced amounts. In biomedical literature, over 536 research papers on "Black Seed" have been published to date. Black Seed's nutritional and therapeutic values have mostly been attributed to thymoquinone, nigellone and melatin in restoring hormonal balance, enhancing immune function and reducing inflammation including other human health benefits. Most importantly, consistent use of Black Seed significantly improves brain function associated with cognitive function, depression, epilepsy, memory and also prevents inflammation because they are especially loaded with polyunsaturated fatty acids, which are essential for protecting nervous system against any neuronal injury and/or disorders. This review provides a comprehensive overview of the science behind the miraculous effects and modern uses of Black Seed.