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Traditional medicinal formulation, chyawanprash-A review
... Boiling of Amla fruits with decoction and the subsequent cooking processes might be inducing pH change, release of acid soluble contents, hydrolysis/cleavage of various bioactive molecules, extraction of soluble chemicals, exchange with intra/extra cellular chemicals of mixture, and several suitable phytochemical interactions to make an ideal blend of this nutraceutical. Some Ayurvedic additives, Shukti Bhasma (pearl oyster calx) 100 g, Abhraka Bhasma (mica calx) 100 g, Shringa Bhasma (deer horn calx) 100 g, Makardhawaja (preparation of red sulphide of mercury and gold) 25 g, clove 25 g and Rajata (silver foil) 75 in number, for special health benefits, are also added by some manufacturers [1]. ...
... The whole unit operating process of traditional CP preparation is depicted in Figure 2. Boiling of Amla fruits with decoction and the subsequent cooking processes might be inducing pH change, release of acid soluble contents, hydrolysis/cleavage of various bioactive molecules, extraction of soluble chemicals, exchange with intra/extra cellular chemicals of mixture, and several suitable phytochemical interactions to make an ideal blend of this nutraceutical. Some Ayurvedic additives, Shukti Bhasma (pearl oyster calx) 100 g, Abhraka Bhasma (mica calx) 100 g, Shringa Bhasma (deer horn calx) 100 g, Makardhawaja (preparation of red sulphide of mercury and gold) 25 g, clove 25 g and Rajata (silver foil) 75 in number, for special health benefits, are also added by some manufacturers [1]. ...
... Chyawanprash has also been found to relieve gastritis, peptic ulcer, gut cramps, and correct the gastrointestinal functions. It purifies blood, works as detoxifier, and promotes healthy liver function [1,64]. It protects and strengthens the liver and kidneys and improves lipid and protein metabolism [87][88][89][90][91]. ...
Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.
... Chyawanprash is used as a household remedy all over India popular for its nutritional value, as a proven energizer, immunity booster and preemptive tonic with multiple health benefits [1]. A complex mixture of more than 50 herbal ingredients known to be responsible for maintaining physique, vigour and vitality [2,3] is relished in India for the past 4000 years [4]. ...
... According to the Charaka Samhita, chyawanprash is "the foremost of all rasayanas" [6] known for delaying the ageing process and had been one of the most respected anti-ageing ayurvedic tonic, long before the clinical importance of vitamins, minerals and antioxidants was appreciated [1]. All the ingredients in Chyawanprash have been scientifically studied individually for their health benefits. ...
... Consumption of Rasayana is helpful to increase the immunity and keep the body away from disease [18]. Chyawanprash delays the ageing process [1] and was used as antiageing ayurvedic tonic long before the clinical importance of vitamins, minerals and antioxidants was appreciated [7]. ...
... CP can be consumed in all seasons as it contains weather friendly ingredients which nullify unpleasant effects due to extreme environmental and climatic conditions. [7] Beneficial effects of CP have been observed in nasal allergies and viral infections and seasonal influences. [7][8][9] There exists enough evidence suggesting its multifaceted biological activity in favor of positive health. ...
... [7] Beneficial effects of CP have been observed in nasal allergies and viral infections and seasonal influences. [7][8][9] There exists enough evidence suggesting its multifaceted biological activity in favor of positive health. Till now CP has been studied in diverse population and there is scarcity of documented data regarding its use in children, specially, school going children. ...
... [22] CP also contains honey which works as 'a carrier of herbs', or Yogavāhī, thereby potentiates absorption of various herbs deep into the tissues and imparts youth, charm, vigour and longevity. [7] In the current study as well, the subject diaries were evaluated to assess the change in energy, physical fitness, strength and stamina. Under all of these parameters, fair amounts of improvement were observed at end of three months that continued until the end of the study in both groups. ...
Context: Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing process. Benefits of CP have been studied widely in adult population. Objectives: Current study assessed beneficial effects of CP on health and immunity related parameters in healthy children. Methods: This study was a 6 month long two armed, randomized, open labeled, prospective clinical study. School going healthy children between ages of 5-12 years were randomized to receive orally daily either CP (approx. 6 g) followed by a cup of milk (100 – 200 ml) or cup of milk only twice a day while continuing with their normal/routine diet. Results were analyzed based on number of episodes, severity, duration of illness (infections and allergies) and number of absent days due to illness during the study duration and changes in levels of energy, physical fitness, strength, stamina and quality of life in children which were recorded in subject diary by their parents/Legally Acceptable Representative (LAR). Results: 702 participants were randomized, out of which 627 completed the study (CP n = 313; Control n = 314). Results of immunity (episodes of infections or allergy related conditions) showed more than 2 times protection from immunity related illness in CP Group as compared to the control. CP also showed better percentage improvement in energy levels, physical fitness, strength, stamina and quality of life assessed through KIDSCREEN QOL-27 questionnaires in children. Conclusion: Regular consumption of CP for a period of six months could significantly improve immunity, energy levels, physical fitness, strength, stamina and quality of life in school going healthy children.
Study Registration: Clinical Trail Registry of India vide CTRI/2015/02/005574, Dated 24 February 2015.
... Chyawanprash is indeed a rich health supplement made of several herbs, herbal extracts, and processed minerals, and has been an essential part of the Indian diet for a long time. Health benefits associated with Chyawanprash have been recognized even before the minerals, vitamins, and antioxidants became popular as health supplements (Parle and Bansal, 2006). ...
... Several studies have verified that Chyawanprash has several health benefits (Sharma et al., 2019). It is known to improve digestion and metabolism by fortifying liver and kidney functions (Trikam, 1979;Sharma, 2003;Parle and Bansal, 2006). Chyawanprash protects and strengthens the respiratory system. ...
The time-tested Ayurvedic medicinal food, Chyawanprash, has been a part of the Indian diet since ancient times. It is an extremely concentrated mixture of extracts from medicinal herbs and processed minerals, known for its immunity boosting, rejuvenating, and anti-oxidative effects. In this study, we have evaluated the anti-inflammatory potential of Patanjali Special Chyawanprash (PSCP) using the zebrafish model of inflammation. Zebrafish were fed on PSCP-infused pellets at stipulated doses for 13 days before inducing inflammation through lipopolysaccharide (LPS) injection. The test subjects were monitored for inflammatory pathologies like behavioral fever, hyperventilation, skin hemorrhage, locomotory agility, and morphological anomaly. PSCP exerted a strong prophylactic effect on the zebrafish that efficiently protected them from inflammatory manifestations at a human equivalent dose. Expression levels of pro-inflammatory cytokines, like interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β), were also reduced in the LPS-stimulated zebrafish fed on PSCP-infused pellets. Skin hemorrhage, hyperventilation, and loss of caudal fins are characteristics of LPS-induced inflammation in zebrafish. PSCP prophylactically ameliorated skin hemorrhage, restored normal respiration, and prevented loss of caudal fin in inflamed zebrafish. Under in vitro conditions, PSCP reduced IL-6 and TNF-α secretion by THP-1 macrophages in a dose-dependent manner by targeting NF-κB signaling, as evident from the secreted embryonic alkaline phosphatase (SEAP) reporter assay. These medicinal benefits of PSCP can be attributed to its constitutional bioactive components. Taken together, these observations provide in vivo validation of the anti-inflammatory property and in vitro insight into the mode-of-action of Chyawanprash, a traditionally described medicinal food.
... Amla (Phyllanthrus emblica), the richest source of Vitamin C and a Homeostasis sustainer are used as a base in the formulation of chyawanprash. [2] On regular consumption ofit is beneficial in maintenance of body function and having health beneficiary, preventive and curative role in health. [1,2] Kidney stone or Nephrolithiasis is a most common and ancient condition in which calculi(stones) form within the tubular lumen and renal pelvis of individual. ...
... [2] On regular consumption ofit is beneficial in maintenance of body function and having health beneficiary, preventive and curative role in health. [1,2] Kidney stone or Nephrolithiasis is a most common and ancient condition in which calculi(stones) form within the tubular lumen and renal pelvis of individual. In India, Kidney stone is prevalent, with an expectancy of 12% in a total population reported to be prone to urinary stones. ...
Nephrolithiasis is a process of forming renal calculi or stones in the kidneys. Certain biochemical changes such as formation of reactive oxygen species are the potential causes for epithelial tissue damage resulting in the idiopathic formation and accumulation of calcium oxalate crystals. There are many evidences available for the protective involvement of antioxidants against oxidative stress in nephrolithiasis. Also many formulations of traditional plants having stone breaking, stone dissolving, and diuretic activities, are available in market as ayurvedic treatments for nephrolithiasis. Most of the ayurvedic formulations available in the treatment of nephrolithiasis are generally churna, syrups, tablets or capsules. Many patients show incompliance for regularly ingesting these formulations. Chyawanprash is one of the oldest and most popular Ayurvedic preparations; it is widely sold and consumed as a dietary supplement as well as health promotive and disease preventive formulation. Considering these factors the Chyawanprash formulation was made using all these traditional plants having well reported antinephrolithiatic, nephroprotective and diuretic activities to treat nephrolithiasis in effective and compliable manner. Chyawanprash is prepared as per the instructions documented in Ayurvedic texts Charaka Samhita, the ancient Ayurvedic treatise. Its evaluation is done to calculate its organoleptic properties, pH, shelf life, stability and microbial contamination, Phase separation. Hence we can conclude that Chyawanprash will no longer be just an Immunity builder but it can be used as an effective and compliable medicine for nephrolithiasis treatment. Key words: Chyawanprash, Traditional medicine, Nutraceutical formulations, Nephrolithiasis, Kidney stones, Calcium oxalate crystals.
... The same is also emphasized in article written by Milind Parle. [18] www.wjpr.net Sodium is essential for cellular homeostasis and physiological functions. ...
... Daily requirement of sodium is 5gm 18 per day and of vitamin c is 40 mg [16] per day. 100 gms of Chavanprash may provides 52 mg of sodium, 10.29 mg of vit. ...
Chavanprash is a one of the most popular and commonly used remedy. Chavanprash is classified under the category of Rasayan, which not only aims at maintaining physique, vigor and vitality but also delay the Ageing process. It is prepared in large quantity as per Sharangdhar Samhita by using 50 herbs including with main ingredient as Amala (Embelica officinalis). Chavanprash is being used long before the clinical importance of Neutraceuticals was known. Therefore present study is selected to evaluate its true nutritional value by quantifying percentage of Carbohydrates, Proteins, Fats and Sodium and vitamin C presents in Chavanprash and to explore its role as Neutraceutical food. Carbohydrate, protein, fat are the major source of calories required by body daily. 100 g of Chavanprash contains 3.80 g of Fats, 1.08 g of Proteins, 79.12 g of Carbohydrates, 52mg of Sodium, 10.29 mg of Vit. C and provides 355Kcal.
... Rasayana, which constitutes one of the major categories of Ayurveda, aims to maintain youth, vigor and vitality in the body. Among the Rasayana recipes, Chyawanprash ( a l s o s p e l l e d C h y a v a n p r a s h , C h y a v a n a p r a s h a , Chyavanaprasam, etc) is a comprehensive herbal tonic with multiple health benefi ts, and is widely consumed as a dietary health supplement in India [2,3] . Chyawanprash strengthens the functions of the liver, heart, immune system and the respiratory system [2,[4][5][6] ; improves memory and learning ability [7,8] ; reduces postprandial glycemia and blood cholesterol [9] and shows antioxidant, antimutagenic and anticarcinogenic activities [10][11][12] . ...
... Among the Rasayana recipes, Chyawanprash ( a l s o s p e l l e d C h y a v a n p r a s h , C h y a v a n a p r a s h a , Chyavanaprasam, etc) is a comprehensive herbal tonic with multiple health benefi ts, and is widely consumed as a dietary health supplement in India [2,3] . Chyawanprash strengthens the functions of the liver, heart, immune system and the respiratory system [2,[4][5][6] ; improves memory and learning ability [7,8] ; reduces postprandial glycemia and blood cholesterol [9] and shows antioxidant, antimutagenic and anticarcinogenic activities [10][11][12] . ...
Objective:
Chronic exposure to ultraviolet (UV) radiation induces skin photoaging (premature skin aging). UV irradiation generates reactive oxygen species (ROS), which are shown to play a pivotal role in skin photoaging. Ayurveda is a holistic traditional medical system, and Chyawanprash is one of the most popular formulations in Ayurveda. Since maintenance of the function and appearance of skin is important, we examined whether Chyawanprash has a protective effect on skin photoaging.
Methods:
To examine the effect of Chyawanprash on skin photoaging, hairless mice were administered with Chyawanprash in drinking water for 3 weeks, and then repeatedly exposed to ultraviolet light B (UVB) irradiation (225 or 450 mJ/cm2) to induce skin photoaging. To further examine the function of Chyawanprash, its effects were examined in cells cultured in vitro. Chyawanprash was added in culture medium, and examined for the effect on the growth of human keratinocytes, and for the ability to eliminate ROS which generated by paraquat (50 μmol/L) in HeLa cells.
Results:
UVB irradiation caused symptoms such as rough skin, erythema, and edema on the skin in hairless mice, but administration of Chyawanprash relieved these symptoms. Further, Chyawanprash significantly suppressed epidermal thickening, a typical marker of skin photoaging, in mice. We then analyzed the effect of Chyawanprash in human cells in culture, and found that Chyawanprash enhanced the growth of human keratinocytes, and efficiently eliminated ROS, which are causally involved in skin photoaging, in HeLa cells.
Conclusion:
These findings suggested that Chyawanprash may have beneficial effects on slowing skin photoaging.
... Uraria picta a perennial herb belongs to family Leguminosae and is distributed in India, China, Burma, Sri Lanka, Africa, and Northern Australia (Yadav et al. 2009;Ahire et al. 2009). The plant species is one of the important constituents in herb formulation called 'Dashmula, and is a well-established ayurvedic drug of the Indian system of medicine for treating general fatigue, oral sores, several gynaecological disorders and also used as an antidote to the dangerous Indian venomous snake echiscarinata (Parle and Bansal 2006).Different parts of the plant are known for possessing diverse medicinal properties such as its leaves, roots and pod extracts were found to have antiviral, antimicrobial and acaricidal activities respectively ( (Igboechi et al. 1989;Rahman et al. 2007). One of the major bioactive flavonoid constituent rhoifolinis being considered as marker compound for qualitative and quantitative standardization of this ethno-medicinal plant (U.picta). ...
The plant Uraria picta is a well-known medicinal herb with extremely small populations found in Indian geographical regions and has an economically important value for medicine and pharmaceutical purposes but the species has declined sharply mainly due to habitat destruction and its overexploitation for medicinal and aesthetic values from its natural habitat that fetched it in the list of critically endangered species, so its effective conservation strategies are required urgently and moreover there is a limited information about its genuine authentication as the species resembles with similar other related plants and therefore became a little challenging task in classification category. Here we report first SCAR marker (GenBank: MF770709) for its germplasm authentication. Furthermore in the simple sequence repeat (SSR) analysis we find mean Nei’s genetic diversity (1.8704) and lowest Shannon information index (0.5147) among the accessions and in AMOVA analysis we observed variation that shows a little significant value of (P < 0.001). Principle coordinates examination (PCoA) was performed to check the multidimensional relationships between the accessions of U. picta. The PCA graph matches the UPGMA cluster tree that demonstrate close assassinations between the germplasm, however from the inter-transcribed sequence analysis we did not find any major genetic diversity among the accessions. The above mentioned study will be helpful and a way forward in germplasm authentication, conservation and restoration of the above species.
... Orpiment, realgar, and arsenic trioxide (ATO) are used in Ayurveda since ancient times (Nayek et al., 2023;Paul et al., 2023). Additionally, in India, arsenic-containing ayurvedic medicines such as Bhasmas were used (Parle and Bansal, 2006;Zhang et al., 2012). Since the bygone age, arsenic has been reported to be used in treating ulcers, mainly the arsenic sulfide part present in realgar (Wu et al., 2011). ...
Arsenic, ubiquitous in various industrial processes and consumer products, presents both essential functions and considerable toxicity risks, driving extensive research into safer applications. Our investigation, drawing from 7182 arsenic-containing molecules in the Cambridge Structural Database (CSD), outlines their diverse bonding patterns. Notably, 51% of these molecules exhibit cyclic connections, while 49% display acyclic ones. Arsenic forms eight distinct bonding types with other elements, with significant interactions observed, particularly with phenyl rings, O3 and F6 moieties. Top interactions involve carbon, nitrogen, oxygen, fluorine, sulfur, and arsenic itself. We meticulously evaluated average bond lengths under three conditions: without an R-factor cut-off, with R-factor ≤0.075, and with R-factor ≤0.05, supporting the credibility of our results. Comparative analysis with existing literature data enriches our understanding of arsenic's bonding behaviour. Our findings illuminate the structural attributes, molecular coordination, geometry, and bond lengths of arsenic with 68 diverse atoms, enriching our comprehension of arsenic chemistry. These revelations not only offer a pathway for crafting innovative and safer arsenic-based compounds but also foster the evolution of arsenic detoxification mechanisms, tackling pivotal health and environmental challenges linked to arsenic exposure across different contexts.
... Based on similarities in the preparations and the range of indications, similar mechanisms of action can also be assumed for MAK. Both Chyavanprash and the classic Ayurvedic recipe Brahma Rasayana, on which MAK is based, are classified as rasayana in Ayurveda, aimed at maintaining vigor, vitality, and delaying the aging process (14). These mechanisms might contribute to its therapeutic potential for various health conditions. ...
Background
Maharishi Amrit Kalash (MAK) 4 and 5 are Ayurvedic herbal nutritional supplements that are believed to have beneficial effects on overall health and wellbeing. This study aimed to systematically review all available randomized controlled trials (RCTs) investigating the clinical effects and safety of MAK.
Methods
We included RCTs on therapy, health promotion, and prevention for patients and healthy volunteers of all ages. We systematically searched MEDLINE (via PubMed), EMBASE (via Ovid), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), DHARA, Clinicaltrials.gov, the World Health Organization (WHO) International Clinical Trials Registry Platform, and Google Scholar from inception through 7 May 2023, with no time or language restrictions. The risk of bias was assessed using the Cochrane Risk of Bias Tool version 1. The protocol was registered with PROSPERO before conducting the review (CRD42023421655).
Results
Three RCTs with 418 study participants were included. Two studies were on breast cancer patients and one on healthy adults. The two studies on cancer evaluated the efficacy of MAK in reducing the side effects of chemotherapy in women with breast cancer. The study on healthy adults evaluated whether MAK has an effect on an age-related alertness task as an indicator of cognitive aging. Both studies on breast cancer patients found beneficial effects on performance status, anorexia, vomiting, and body weight. One study reported positive effects regarding stomatitis. Regarding visual alertness, results showed that individuals who received MAK improved in performance. None of the three included studies reported adverse events. The risk of bias was mixed. Due to the small number and heterogeneity of the RCTs, no meta-analysis could be performed.
Conclusion
There is evidence that MAK may have supportive effects in chemotherapeutic treatments for breast cancer patients and for healthy individuals regarding visual discrimination. However, it is difficult to verify treatment effects due to the small number of RCTs and the mixed risk of bias. Furthermore, none of the included studies recorded adverse events. Therefore, further high-quality studies are warranted to confirm the potential health benefits of MAK and to determine its optimal dosage and duration of use.
Systematic review registration
PROSPERO, CRD42023421655.
... Apart from Dashmula, U. picta also happens to be a key ingredient of more than 100 Ayurvedic formulations viz., Amritarishta, dashmulachurna, Abhrak bhasma, Brahma rasayan, Dahmula taila, Rajanyadi churna, Anu Taila etc. (Pathak et al., 2005). The plant is useful to cure general debility, nervine tonic, cardiac and blood disorders and antidote for snake venom (Parle and Bansal, 2006) Doodia picta Roxb., Hedysarum pictum Jacq., Uraria aphrodisiaca Welw., U. leucantha Span. and U. linearis Hassk. ...
Uraria picta is a woody herb found throughout Asia, Africa and Australia. It has been long known to possess significant ethnomedicinal value. It is a key ingredient of more than a hundred Ayurvedic formulations and an important component of many patents in countries like India, China, Japan and USA. U. picta is commercially important and in high demand in India and Western African countries. As a consequence, U. picta has now been classified as a rare, endangered and threatened (RET) species in India. Biochemical analysis of different plant parts of U. picta and its tissue culture has shown that it is a valuable source of several bioactive phytochemicals among which Rhoifolin is the most recognized. In this work, relevant details on ethnobotany, bioactive compounds, pharmacology, toxicology, tissue culture and commercial applicability U. picta were retrieved from Google Scholar, Scopus, SpringerLink, Pubmed and Science Direct from 1950 to 2022. The seeds have a good balance of essential amino acids and the proportion of these amino acids is almost on par with that of nutritionally important common legumes and cereals. Given its status as an endangered species a number of reports have now appeared on methods of micropropagation of the plant as a means for conservation. The plant possesses several medicinal properties viz., anticancer, anti-inflammatory, antidiabetic, antimicrobial, etc. These studies mainly focus on the plant extract and not on the individual metabolites. Also, there is a dearth of reports on the mechanism of action of phytochemicals at the molecular levels. Thus, we provide perspective useful for bridging the gap that remains in the scientific validation of traditional uses of the plant through proper objectives and experimentation to explore novel therapeutic leads from U. picta with industrial viability. We also recommend the use of metabolic engineering and plant tissue culture (using elicitors and precursors) as approaches to increase the production of important bioactive molecules from this plant.
... Different products of amala like murabba, juice, jam, cheese, candy, powder, beverage, chutney, leather etc are preferred by the consumers being the rich source of vitamin C and antioxidants [2]. Amala is one of the main constituents of many ayurvedic preparations like Triphla and Chyawanprash [3][4][5]. Chatni also called as "chutney" is a condiment mostly used in Nepal and the Indian subcontinent made of fruits and/or vegetables, sugar, salt, spices and herbs. The product is prepared from peeled, sliced or grated unripe or semi-ripe fruits and /or vegetables by cooking the shredded part with salt over medium heat for 5-10 min (depending upon the volume, vessel size and nature of raw materials), mixing and then adding sugar, spices and vinegar then filled hot in sterilized jars. ...
This study was aimed to prepare amala (Phyllanthus emblica L.) chutney and to determine its phytochemicals and nutritional compositions, antioxidant activity and sensorial properties. The amala pulp and sugar were mixed separately at the proportion of 70:30, 60:40, 50:50, 40:60 and 30:70 and labeled as samples A, B, C, D and E respectively. Sample A exhibited highest tannins, total polyphenols, flavonoids content and percent DPPH inhibition (198.9 mg GAE/g, 606 mg GAE/g, 153.47 mg QE/g and 61.67% respectively), and sample B exhibited highest ascorbic acid content (325.4 mg/100g) among the chutney samples. The crude proteins, crude fat, crude fiber, total ash and moisture content were higher (2.1%, 0.328%, 5.03%, 1.73% and 51.17% respectively) in sample A. The carbohydrate content and energy value were higher (66.16% and 267.9 Kcal/100 g respectively) in sample E. Total sugar, TSS and pH (75.93%, 60.3 °Bx and 4.56 Original Research Article Electronic copy available at: https://ssrn.com/abstract=3987831 Yadav et al.; AFSJ, 18(1): 43-52, 2020; Article no.AFSJ.60169 44 respectively) was higher in sample E while acidity (1.21% as citric acid) was high in sample A. Most of the sensory attributes were significantly higher (P<0.05) in sample C, signifying to use the equal proportion of pulp and sugar for the preparation of amala chutney.
... One of the most renowned prakshapes is the one utilized in the preparation of Chavanprash awaleha. The formulation and preparation process of Chavanprash is given in various ancient Ayurvedic texts [103]. ...
Towards the conclusion of the tedious process of preparing chavanprash, a powdered herb combination known as prakshape is introduced. Many of these herbs have already been utilized in the initial stage of creating the decoction, which is the basis of chavanprash. The perplexing aspect is the necessity to incorporate the same herbs once more as prakshape during the final step, highlighting the intriguing nature of this addition and its associated benefits. The inclusion of prakshape proves to be ingenious for multiple reasons. Firstly, the incorporation of powdered herbs in prakshape ensures that the entire herb, along with all its phytochemical components, becomes part of the formulation. In contrast, the decoction process only extracts water-soluble components into the solution. This inclusion allows for a broader range of active compounds to be present in the final product. Secondly, the addition of prakshape serves to reintroduce volatile and heat-labile compounds that may have been lost during the extended heating process. Additionally, the inclusion of bamboo (Bambusa arundinacea) manna particles in prakshape contributes to an enhanced drug-delivery system. From a pharmacological standpoint, the incorporation of prakshape ingredients reinforces the therapeutic effects of the formulation and promotes synergy among the herbs. The principles underlying the use of prakshape can further be utilized for the development of new awaleha and ksheerpak formulations, potentially yielding more potent effects.
... One of the most renowned prakshapes is the one utilized in the preparation of Chavanprash awaleha. The formulation and preparation process of Chavanprash is given in various ancient Ayurvedic texts [103]. ...
Towards the conclusion of the tedious process of preparing chavanprash, a powdered herb combination known as prakshape is introduced. Many of these herbs have already been utilized in the initial stage of creating the decoction, which is the basis of chavanprash. The perplexing aspect is the necessity to incorporate the same herbs once more as prakshape during the final step, highlighting the intriguing nature of this addition and its associated benefits. The inclusion of prakshape proves to be ingenious for multiple reasons. Firstly, the incorporation of powdered herbs in prakshape ensures that the entire herb, along with all its phytochemical components, becomes part of the formulation. In contrast, the decoction process only extracts water-soluble components into the solution. This inclusion allows for a broader range of active compounds to be present in the final product. Secondly, the addition of prakshape serves to reintroduce volatile and heat-labile compounds that may have been lost during the extended heating process. Additionally, the inclusion of bamboo (Bambusa arundinacea) manna particles in prakshape contributes to an enhanced drug-delivery system. From a pharmacological standpoint, the incorporation of prakshape ingredients reinforces the therapeutic effects of the formulation and promotes synergy among the herbs. The principles underlying the use of prakshape can further be utilized for the development of new awaleha and ksheerpak formulations, potentially yielding more potent effects.
... Apart from Dashmula, U. picta also happens to be a key ingredient of more than 100 Ayurvedic formulations viz., Amritarishta, dashmulachurna, Abhrak bhasma, Brahma rasayan, Dahmula taila, Rajanyadi churna, Anu Taila etc. (Pathak et al., 2005). The plant is useful to cure general debility, nervine tonic, cardiac and blood disorders and antidote for snake venom (Parle and Bansal, 2006) Doodia picta Roxb., Hedysarum pictum Jacq., Uraria aphrodisiaca Welw., U. leucantha Span. and U. linearis Hassk. ...
Gymnema sylvestre R.Br. (Family: Apocynaceae), commonly called ‘gurmar’, is a commercially important medicinal plant. It is traditionally used as an antidiabetic agent, which is mainly due to the presence of gymnemic acids (triterpenoid glycosides). The plant is also a good source of oleanane-type triterpenoid saponins, flavonoids, steroidal glycosides, sterols, etc. Gurmarin, a protein, is known to suppress sweet taste. Its bioactive compounds have shown diverse therapeutic potentials viz., anticancer, anti-inflammatory, antidiabetic, radioprotective, antimicrobial, hypolipidaemic. Some of these medicinal properties have been validated through clinical trials. The present review focuses on the traditional phytochemical, medicinal properties, pharmacological and clinical trials undertaken on G. sylvestre.
... It is also referred to as chyavanaprasha, chyavanaprash, chyavanaprasam, and chyawanaprash. CP has stood out as the most significant Rasayana formulation among those described during the classical and medieval eras [23,24]. Since ancient times, chyawanprash has been utilized both as a medicine to improve immunity and lengthen life and as a health supplement due to its many positive health effects. ...
Globally, non-communicable diseases (NCDs) and communicable diseases (CDs) are on the rise, posing a significant public health threat. A holistic ayurvedic preparation called chyawanprash (CP) has shown positive outcomes in NCDs and CDs. Hence, we aimed to report the outcomes in a systematic manner. To determine the safety, efficacy, healthcare utilization, and quality of life of CP as an optional therapy for NCD and CD management. This systematic review will adhere to PRISMA-P and Cochrane guidelines for methodological considerations. It will evaluate CP efficacy in diverse populations, considering Ayurvedic and non-Ayurvedic comparators. The study design will encompass randomized controlled trials (RCTs) published from 2010 to 2023 in healthcare settings, controlled environments, and communities. We will also analyze primary outcomes related to immunity biomarkers, vital signs, and secondary outcomes such as quality of life. Data sources and search strategy will involve systematic searches in databases such as Cochrane, PubMed, Google Scholar, Web of Science, and Scopus using MeSH terms and Boolean operators. Screening and data extraction will follow a standardized form with four independent reviewers. Quality assessment will use the Cochrane risk of bias tool. The systematic review will provide an exhaustive summary of the effectiveness and safety of CP to address the growing burden of NCDs and CDs. Registration: CRD42023418994.
... It was believed to restore his vitality, vigor, and youthfulness [5,6]. Chyawanprash has a long history in Ayurvedic medicine and has been used for generations as a health supplement and medicine [7][8][9][10][11]. It is considered a polyherbal compound, meaning it contains a mixture of various herbs and herbal extracts. ...
This research aims to study the functional properties and sensory evaluation of therapeutic bars and their consumer acceptability. The therapeutic bar was prepared and formulated by using a mixture of millets and chyawanprash composition. Chyawanprash is made up of Indian gooseberries, dates, jaggery, clarified butter, sesame oil, honey, dry ginger powder, cloves, pipli, green cardamom, cinnamon, cumin seeds, black pepper corn, mace spice, fennel seeds, bay leaf, rose petals, saffron strands, some herbs (ashwagandha, shatavari, mulethi and giloy). For making therapeutic bar some other ingredients included eg; millets (sorghum and pearl millets). Therapeutic bar is made by using formulation of chyawanprash composition with millets. Thirty members of the department of food and nutrition team sampled therapeutic bar. 9 point hedonic scale is used for sensory evaluation of therapeutic bar. Due to its rich nutritional profile and as well as the several hundred years that of years that chyawanprash previously used as health supplement and nutraceutical food product. This bar is nutrient-dense as a result of the combination of sorghum and pearl millets. It is meant to refill depleted reserves of life force and to sustain stamina, strength, and vitality while slowing the ageing process. As a result, the purpose of this research is to develop a wholly herbal chyawanprash with outstanding immune boosting efficacy and a very appealing sort of formed bar.
... Its major constituent is Indian gooseberry, which is a rich source of Vitamin C also. This is a most advantageous rasayana formulation for maintaining homeostasis [20]. ...
In Ayurveda, polyherbal preparations appear to be an unavoidable medicinal approach. Many polyherbal medicines are prepared by local medical practitioners from rural regions of Thiruvananthapuram district, who follow their ethnic customs. The current study was an investigation of their medical system in order to determine the types of plants and plant parts that are used as main components in medicinal compositions. In this study, fifty plants from 34 distinct families were found to be used in the preparation of various Ayurvedic medicines. Solanaceae, Fabaceae, Zingiberaceae, and Piperaceae were the most important among the 34 families studied in terms of the number of herbal medications produced. The most prevalent constituent in 66 percent of currently investigated formulations is Zingiber officinale, followed by Piper longum and Aegle marmelos. The root was found to be the most commonly used plant portion, and harvesting the entire plant could lead to the natural depletion of supply materials. Many of the plants are also becoming threatened. This leads to drug adulteration, necessitating the development of procedures for detecting contaminated products.
... The best example is the famous Chyawanprash. This is a herbal tonic that is composed of various herbs, micro and macronutrients and antioxidants (Parle and Bansal, 2006). The pharmacological reports in different researches suggest that about 80 % of the drugs manufactured are isolated from nature (Atanasov et al., 2015). ...
... It has the hepatoprotective effect, and it reduces postprandial glycemia and blood cholesterol levels. It is made up of around 50 herbs, including Amla i.e., Indian gooseberry as a key ingredient which is a rich source of vitamin C with sugar syrup, sesame oil, and clarified butter 8,37,38 . The end product has a fruit-like consistency, which is sweet, sour, and slightly spicy in nature 39,9 . ...
Moringa oleifera and chywanprash are two main nutraceuticals used worldwide because of their large medicinal application. The quality of these nutraceutical products is in question, especially due to the inorganic contaminants like heavy metals. In the present study, six Moringa herbal powder and five chywanprash samples were collected in India and further analyzed for As, Cd, Hg, and Pb. All samples were microwave digested and analyzed by ICP-MS. In Moringa As, Cd, Hg and Pb were found in the range of 0.027-5.264 µg/mL, 0.014-0.039 µg/mL, 0.049-45.225 µg/mL and 0.323-12.487 µg/mL respectively. In chywanprash As, Cd, Hg and Pb were found in the range of 0.012-0.021 µg/mL, 0.004-0.029 µg/mL, 0.01-0.103 µg/mL and 0.06-0.171 µg/mL respectively. The concentration of these heavy metals were found to be more than the maximum permissible limit given by the WHO for herbal medicines. Hence strong regulatory guideline needs to be prepared to improve quality of nutraceuticals.
... In India, many plants and herbal formulations are documented to increase immunity, and their compounds can be screened against the coronavirus. Chyawanprash, a famous herbal formulation is prepared by processing around 50 such important medicinal herbs which possess multiple health benefits, including boosting the immune system for all age groups (Parle & Bansal, 2006). ...
A computational investigation was carried out to find out potential phytochemicals that could inhibit the binding of human angiotensin-converting enzyme-2 (ACE2) receptors to spike protein of SARS-CoV-2 which is an essential step to gain entry inside human cells and onset of viral infection known as Coronavirus disease (COVID-19). A library of phytochemicals was screened by virtual screening against ACE2 receptors resulting in twenty phytochemicals out of 686 which had binding energy (−11.8 to −6.9 kcal/mol). Drug-likeness gave five hits, but ADMET analysis yielded 4 nontoxic hit phytochemicals. Molecular dynamics simulation of four-hit compounds resulted in acceptable stability and good dynamics behavior. These phytochemicals are Hinokinin, Gmelanone, Isocolumbin, and Tinocordioside, from Vitis vinifera, Gmelina arborea, and Tinospora cordifolia. The above-mentioned phytochemicals may be promising ACE2 inhibitors and can prevent infection of SARS-CoV-2 by inhibiting the entry of the virus into host cells.
Communicated by Ramaswamy H. Sarma
... Commercial sugar-free CP produced for diabetes [8] and spicy cookies [6] does not contain sugar and honey as in classical CP, which not only improves the palatability, but also works together as 'Yogavahi' (carrier of herbs), to catalyze the delivery of a particular bioactive drug component and encourages its penetration deep into the cells [2,5,9]. Based on this fact, the execution process of the commercial CP [6,8] may be altered. ...
... In the present article, we give a conceptual overview on how a new generation of immunotherapeutic agent derived through green nanotechnology, integrating Mangiferin phytochemical onto well-defined gold nanoparticles (MGF-AuNPs), can be developed for use in prostate cancer therapy. Interestingly, combination of gold metal with phytochemicals has been used for over 5000 years in the Indian holistic Ayurvedic Medicine [63][64][65][66][67][68][69][70][71] . Our green nanotechnology approach of encapsulating Mangiferin onto gold nanoparticles represents an integrative momentum to merge the best of two worlds of modern nanomedicine with the traditional Ayurvedic medicine. ...
Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunomodulatory intervention of MGF-AuNPs in prostate cancers through observations of enhanced levels of anti-tumor cytokines (IL-12 and TNF-α) with concomitant reductions in the levels of pro-tumor cytokines (IL-10 and IL-6). In the MGF-AuNPs treated groups, IL-12 was elevated to ten-fold while TNF-α was elevated to about 50-fold, while IL-10 and IL-6 were reduced by two-fold. Ability of MGF-AuNPs to target splenic macrophages is invoked via targeting of NF-kB signaling pathway. Finally, therapeutic efficacy of MGF-AuNPs, in treating prostate cancer in vivo in tumor bearing mice, is described taking into consideration various immunomodulatory interventions triggered by this green nanotechnology-based nanomedicine agent.
... It relaxes the bowel and tones the liver and kidney (Hegde, 2012). Sesame seed oil is used as a tonic, aphrodisiac, nutrient, diuretic and for treating asthma, dry cough, ulcers, inflammation, urinary disease, vertigo, lung disease and migraine (Parle and Bansal, 2006). In India, the tribals of Maharashtra (Nandurbar district) use crushed seeds of Sesame to get relieve abdominal pain (Tayade and Patil, 2005). ...
Ethnopharmacological relevance
Sesamum indicum L. (Pedaliaceae) is an annual plant, which has been domesticated for well over 5000 years. It is widely cultivated for its seeds and is one of the oldest known oilseed crops. Traditionally, its seeds, seed oil, and different organs of the plant have been used to treat various diseases or conditions like ulcers, asthma, wound healing, amenorrhea, hemorrhoids, inflammations, etc.
Aim of the review
The main aim of this review is to provide an outline and to assess the reported ethnopharmacological, phytochemical, pharmacological and toxicological studies of Sesamum indicum L.
Materials and methods
An extensive literature survey was done on various search engines like PubMed, Web of Science, Scopus, SciFinder, Google Scholar, Science direct, etc. Other literature sources like Wikipedia, Ethnobotanical books, Chapters were also studied to get maximum information possible on the Sesamum indicum L.
Results
Over 160 different phytochemical compounds have been characterized and isolated from seeds, seed oil, and various plant organs, including lignans, polyphenols, phytosterols, phenols, anthraquinones, naphthoquinones, triterpenes, cerebroside, fatty acids, vitamins, proteins, essential amino acids, and sugars using suitable analytical techniques (e.g., LC-MS, GC-MS, HPTLC, HPLC). All the reported pharmacological activities like antioxidant, anticancer, antipyretic, antihypertensive, hepatoprotective, and anti-inflammatory are due to the virtue of these phytochemical compounds.
Conclusion
This review mainly highlights the botanical aspect of Sesamum indicum and its phytochemical constituents, ethnomedicinal uses, different pharmacological activities followed by ongoing clinical trials and future prospects. Sesamum indicum has great importance in traditional Indian medicine, which is further supported by modern pharmacological studies, especially in hepatoprotection, inflammation, and cancer. Several researchers have suggested that Sesamum indicum extracts and isolated compounds could have a wide therapeutic potency range. More research is needed to uncover key features of Sesamum indicum in medical practice, such as structure-activity relationships, toxicity, and therapeutic potential. In order to fully explore the plant's potential, safety assessments and implementation of an integrated cultivation method are also areas that need to investigate.
... It is believed that Chyavanprash helps not only in increasing the resistance of the body but also maintaining the homeostasis of the body. [27] Lowering of serum enzymes: The levels of Serum transaminases induced by ethanol (AST and ALT) and IL-1 beta lowered with the advance treatment of rats with Emblica officinalis by 50, 25 and 75 mg per kg body weight with oral dose. [28] Inhibition of hepatotoxicity: Chyavanprash (1 g/kg) and Emblica officinalis (500 mg per kg body weight) extracts were inhibiting hepatotoxicity induced by carbon tetrachloride in rats. ...
Emblica officinalis (EO) (Family: Euphorbiaceae) , commonly called Amla, is a traditional plant, occurring commonly in deciduous forests in India and widely used globally for the management of various ailments. When its phytochemistry is studied in detail, it reveals the presence of vitamin C, ellagic acid, gallic acid, phyllemblin, tannin, phyllemblic acid, lipids and emblicol. The fruit of this plant is commonly used for a cooling, diuretic, laxative activity. It is also used for the treatment of anemia, jaundice and dyspepsia. The seeds are used for the management of different respiratory tract disorders such as bronchitis, asthma, and digestive problems. Various scientists and researchers have isolated the parts of this plant for studying its pharmacological activities and therapeutic approaches. They have explored this plant for its hepatoprotective, gastroprotective, cytoprotective, antitumor, antifungal and antiulcer activity. Further, this plant is also claimed to have other beneficial effects in Ayurveda and traditional medicines. This plant is common and widely available. It is consumed by various Indian people routinely. It is important ingredient of cosmetics, shampoos, hair oils, dyes and famous health tonic Chyavanprash. Though, various literature is available on this plant and fruit but due to interest and curiosity to further explore the information of its uses, chemical composition, pharmacological activities of extract and its isolated compounds and safety profile, the present review paper is planned. This information will be useful for further research of this plant.
... This helps to sleep better. [9][10][11][12][13][14][15][16] Time to Take Chyawanprash 17 Chyawanprash is one of the best medicines used in anti-ageing treatment, called rasayana therapy. Here, after Panchakarma treatment, the patient is made to take chyawanprash for a few weeks to a few months time. ...
Chyawanprash is an Ayurvedic dietary health supplement used for boosting immunity and help in making a person feel young. Chyawanprash is one of the anti-aging supplements, which is purely herbal in nature. It has Amla as its main ingredient, which is a powerful antioxidant. Master Charaka is the first to mention this herbal medicine. Ayurveda recommends the use of herbal supplements to help the increase immunity, restore drained reserves of life force and to preserve strength, stamina, and vitality, while stalling the course of aging. There are many benefits of chyawanprash. It is useful in cough and cold. It helps in the rejuvenation of the aged and also in proper nourishment of young ones. It is effectively used in the treatments of throat infections. Chyawanprash is formulated by processing around 50 medicinal herbs, minerals sugar, honey, ghee, Indian gooseberry jam, sesame oil, berries and spices. Chyawanprash market has seen a sharp rise of 30 to 40 percent in the period of rising cases of coronavirus. This article focused on immunity boosting herbal medicine in COVID-19 pandemic.
... The spices like Curcuma longa (Turmeric), Cuminum cyminum (Cumin), Coriandrum sativum (Coriander), and Allium sativum (Garlic) are recommended in cooking. All these herbs have antioxidant activity [21][22][23][24] and enhance immunity. ...
The world is grappling for US FDA-approved therapies for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). It is the virus that has caused Coronavirus Disease 2019 (COVID-19). Several pharmacological drugs are under various phases of clinical trials, and their current clinical use is primarily based on the in vitro activity against SARS-CoV-2 or related coronaviruses. While the efficacy of drug therapies is yet to be established, and the efficacy of the vaccine for COVID-19 is to be accomplished, we need to focus on prophylactic measures. The current article describes the chemoprophylactic, Ayurvedic, homeopathic, and Unani prophylactic approaches for combating COVID-19 based on the guidelines issued by the Ministry of AYUSH, India. The article is based on the guidelines issued by the Ministry of AYUSH, India. The proposed approaches have been supported by scientific evidence. The article also provides an outlook on the global scenario of herbal practices. In the absence of effective treatment, efforts to control the COVID-19 pandemic heavily rely on non-pharmaceutical interventions such as personal preventive measures. The alternative system of medicine offers prophylactic solutions that are simple and inexpensive. These simple measures will go a long way in tackling the pandemic.
... Daily Cooking Intergradient: it was advised to use Turmeric, Cumin , Coriander and Garlic in cooking, and Takeing (10g) Chyawanprash in the morning, (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging [14]. ...
The new coronavirus (Covid-19) has spread to nearly every country in the world, till now there is no specific treatment, and the work to develop a vaccine is accelerating but it is unlikely to be available until next year. Doctors and researchers are concentrating that a central player in the fight against the novel coronavirus is the immune system that it can even be helpful for its therapy, since that the virus is important, but the host response is at least as important, if not more important in this situation with absence of remedy it is essential for the shift of complementary and traditional medicine from the marginal status it holds to a significant role in international health care , whereas Ayurveda main goal is to promote good health, not fight disease. Ayush ministry considered that and released one protocol to boost immune human system (both physical and psychological) to win the battle, this article is a try to address the guidelines of this protocol by explaining it.
... Plants that are used by traditional practitioners in folklore practice were documented from different published articles pertaining to that particular area, 8,22,23 text books related to medicinal plants, [24][25][26][27][28][29] and other published articles related to ethnomedicine. 13,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Information regarding their classical uses is compiled from text books related to Ayurveda. [50][51][52] The available information is presented systematically with botanical name, family, voucher number, latitude and longitudes, Sanskrit and local names, known traditional uses, and classical indications. ...
... It is incredibly useful in preventing stomachache, common cold and coughs which are supposed to be the symp-toms seen in COVID-19. On regular consumption, CP improves overall health problems (Parle and Bansal, 2006). ...
Chyavanprash a known Ayurvedic formulation formulated by sage Chyavan to impart youth, charm, strength & prolonged life. It is very much valued for possessing numerous health benefits with respect to the preventive, curative and promotive aspects of health. Chyavanprash can be consumed throughout the year. Several scientific evidences support its wholesome and safe healthy tonic status that is favorable for all age groups and genders alike. In modern days, it has gained mammoth popularity throughout the world. CP is prepared with Amalaki (Emblica officinalis) as a prime drug with other nutrient rich herbs help to preserve stamina, strength and vitality. Various pre clinical (in vivo & in vitro), Experimental, Analytical and clinical studies conducted on CP and its individual components revealed its various pharmacological activities most of which are suggestive of immunity enhancer and health supplements. Hence an attempt is made in the present paper to find out and explore the scientific evidences based on therapeutic potential of CP with respect to immunity and health supplements and make evidences available to the common people to combat the COVID-19 menace effectively.
... Similarly, many other plants are known to increase immunity, and their compounds can be used against the coronavirus. Chyawanprash is one of the most appreciated herbal preparations for boosting the immune system for all age groups (Parle & Bansal, 2006). It is formulated by processing around 40 such medicinal herbs and possesses multiple health benefits. ...
The recent outbreak of SARS-CoV-2 disease, also known as COVID-19, has emerged as a pandemic. The unavailability of specific therapeutic drugs and vaccines urgently demands sincere efforts for drug discovery against COVID-19. The main protease (Mpro) of SARS-CoV-2 is a critical drug target as it plays an essential role in virus replication. Therefore for the identification of potential inhibitors of SARS-CoV-2 Mpro, we applied a structure-based virtual screening approach followed by molecular dynamics (MD) study. A library of 686 phytochemicals was subjected to virtual screening which resulted in 28 phytochemicals based on binding energy. These phytochemicals were further subjected to drug-likeness and toxicity analysis, which resulted in seven drug-like hits. Out of seven, five phytochemicals viz., Mpro-Dehydrtectol (-10.3 kcal/mol), Epsilon-viniferin (-8.6 kcal/mol), Peimisine (-8.6 kcal/mol), Gmelanone (-8.4 kcal/mol), and Isocolumbin (-8.4 kcal/mol) were non-toxic. Consequently, these phytochemicals are subjected to MD, post MD analysis, and MM/PBSA calculations. The results of 100 ns MD simulation, RMSF, SASA, Rg, and MM/PBSA show that Epsilon-viniferin (-29.240 kJ/mol), Mpro-Peimisine (-43.031 kJ/mol) and Gmelanone (-13.093 kJ/mol) form a stable complex with Mpro and could be used as potential inhibitors of SARS-CoV-2 Mpro. However, further investigation of these inhibitors against Mpro receptor of COVID-19 is needed to validate their candidacy for clinical trials.
Communicated by Ramaswamy H. Sarma
... Different products of amala like murabba, juice, jam, cheese, candy, powder, beverage, chutney, leather etc are preferred by the consumers being the rich source of vitamin C and antioxidants [2]. Amala is one of the main constituents of many ayurvedic preparations like Triphla and Chyawanprash [3][4][5]. Chatni also called as "chutney" is a condiment mostly used in Nepal and the Indian subcontinent made of fruits and/or vegetables, sugar, salt, spices and herbs. The product is prepared from peeled, sliced or grated unripe or semi-ripe fruits and /or vegetables by cooking the shredded part with salt over medium heat for 5-10 min (depending upon the volume, vessel size and nature of raw materials), mixing and then adding sugar, spices and vinegar then filled hot in sterilized jars. ...
This study was aimed to prepare amala (Phyllanthus emblica L.) chutney and to determine its phytochemicals and nutritional compositions, antioxidant activity and sensorial properties. The amala pulp and sugar were mixed separately at the proportion of 70:30, 60:40, 50:50, 40:60 and 30:70 and labeled as samples A, B, C, D and E respectively. Sample A exhibited highest tannins, total polyphenols, flavonoids content and percent DPPH inhibition (198.9 mg GAE/g, 606 mg GAE/g, 153.47 mg QE/g and 61.67% respectively), and sample B exhibited highest ascorbic acid content (325.4 mg/100g) among the chutney samples. The crude proteins, crude fat, crude fiber, total ash and moisture content were higher (2.1%, 0.328%, 5.03%, 1.73% and 51.17% respectively) in sample A. The carbohydrate content and energy value were higher (66.16% and 267.9 Kcal/100 g respectively) in sample E. Total sugar, TSS and pH (75.93%, 60.3 °Bx and 4.56 respectively) was higher in sample E while acidity (1.21% as citric acid) was high in sample A. Most of the sensory attributes were significantly higher (P
... The tree is also frequently lopped for fodder (Shah et al 2007).Seeds yield non-drying oil used in perfume industry. It is also used as one of the important ingredients in commonly used many Ayurvedic medicines and preparations (Parle and Bansal 2006). The natural regeneration of Oroxylum indicum is adversely affected owing to its over-exploitation for its various medicinal uses. ...
The current study investigated the effect of container size and potting media on growth and development of Oroxylum indicum. The treatments consisted of four container sizes: root trainer 250 cc, root trainer 300 cc, polybag 16 cm x 24 cm (1500 cc) and polybag 23 cm x 28 cm (4200 cc) and three potting media: soil only, soil: sand: farmyard manure, 1:1:1 and soil: sand: vermicompost, 1:1:1. The container size, potting media and the interaction of container size x potting media exhibited significant effect on the growth and development of all the studied parameters-seedling height, collar diameter, number of leaves, shoot weight, length of primary root, number of secondary roots, root weight, total fresh weight of seedling, total dry weight of seedling, root: shoot ratio, sturdiness quotient and seedling quality index. The effect of potting media on seed germination percentage was significant. The study implies that large sized containers (polybag 23 cm x 28 cm) and potting medium soil:sand:vc (1:1:1) should be used to get better growth of Oroxylum indicum seedlings.
... The Chyavanprasha Avaleha is the most popular Ayurveda Kalpa (formulation) used as immunity booster supplement. [12] But all the contents of Chyavanprasha Avaleha are difficult to collect, having issues of adulteration and also not as much cost effective. On the other hand Chaturthamalaka Rasayana (CR) mentioned in Charaka Samhita, may be one of the suitable option for this Chyavanprasha Avaleha. ...
In Ayurveda, Rasayana is mentioned as a unique preventive as well as curative therapy to achieve healthy long life. The modern medical world is seeking for an alternative class of immunomodulatory drugs, which is nothing but the category of Rasayana. Among this Rasayana formulation, Chaturthamalaka Rasayana (CR) is the one that formulation, mentioned just after Chyavanprasha Avaleha in classical literature of Charaka Samhita. CR consists of four formulations. It is nothing but the simple permutation and combination of Amalaki (Emblica officinalis Gaertn.), Bibhitaki (Terminalia bellerica Roxb.) and Haritaki (Terminalia chebula Retz.) collectively called as Triphala. In present study, it was prepared according to the classical standard operative procedure (SOP) so as to evaluate a physicochemical and phytochemical profile of CR as per standard lab protocols, for all the four formulations under CR, along with the main three raw drugs which ensure the quality. This pharmaceutical analysis differentiates one compound from another by developing its identification markers. As the CR has not been yet studied before, it will be more helpful to evaluate the pharmaceutical screening of this four formulations as an initial step towards standardization. In the future, this study will be helpful to prepare the monograph of CR in the Ayurvedic formulary of India (AFI).
... [8] Sometimes people work for relative approach as they select herbal medicine as these works for their friends and family. [9] WHY PEOPLE PREFER HERBAL MEDICINES? ...
Chyawanprash is an ayurvedic dietary health supplement used for boosting immunity and help in making a person feel young chyawanprash is one of the anti-ageing supplements, which is purely herbal in nature. It has amla as its main ingredient, which is a powerful antioxidant chyawanprash is formulated by processing around 50 medicinal herbs, minerals sugar, honey, ghee, Indian gooseberry jam, sesame oil, berries and spices. It also helps to slow down the aging process improve memory, good heart rate and improve the health of the digestive, digestive and respiratory system. This abstract presents an overview of sugar-free herbal chyawanprash, a modern adaptation of the classic formulation, designed to provide the same health benefits without the inclusion of sugar.the sugarfree variant employs natural sweeteners such as stevia and monk fruit, which do not spike blood glucosee levels, making it suitable for diabetics and those conscious of their sugar intake.
According to the WHO, the Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), no medications/vaccines are proven to be fully effective for the treatment/prevention of SARS-CoV-2. All are aware that the virus is acting through the respiratory system due to lowered immunity of the body and have a devastating effect on the mental health of populations worldwide. There are very remote chances of developing a drug in a short span of time, along with tested safety and efficacy. Hence there is a need to find out some home remedies accessible to all. Here authors propose a food supplement Chaywanprash (ChyPra), which has been used by populations worldwidfor ages without any established side effects. It also contains quinine in minute quantities and a number of proven antiviral active components for SARS CoV. In addition, this formula is recommended in Ayurveda for the maintenance of mental health and rejuvenation.
Sesame (Sesamum indicum) is a flowering plant belonging to the sesamum genus, sometimes referred to as benne. Since prehistoric times, people have grown sesame seeds in tropical climates all throughout the planet. One of the earliest crops to be processed for oil refining was sesame seed. There are a lot of phytochemicals in sesame seeds, both black and white, including eight primary metabolites and sixteen secondary metabolites. Sesame seeds are widely utilised in traditional medicine and cooking due to their nourishing, healing, and protecting qualities. The sesame plant is also used to create a variety of nanoparticles, including iron and silver nanoparticles. For optimal use, an examination of the ethnobotanical and medicinal applications of this very nutritious oilseed—which is also commercially significant—is appropriate. This study's main goal is to learn more about the regular benefits of sesame seeds for pharmacological, medicinal, and ethnobotanical applications.
BACKGROUND
A densitometric High Performance Thin Layer Chromatography (HPTLC) method has been established for simultaneous quantification of Gallic acid, Piperine, and Withaferin A in Chyavanprash . Chyavanprash possesses multiple health benefits including immunity boosting and has been widely used since ancient times. The surge of COVID-19 has further increased its demand resulting lack of monitoring on raw materials to ensure its efficacy.
METHODS
Aluminum plates coated with silica gel 60 F 254 as stationary phase was used with Toluene:Ethyl acetate:Formic acid:Methanol [30:30:8:2] (v/v/v/v) as mobile phase. The plates were developed to a distance of 60 mm at 25 ± 2°C in a chamber previously saturated for 30 min. Densitometric analysis was performed at 254 nm in absorbance mode.
RESULTS
Amounts of Gallic acid, Piperine, and Withaferin A are 0.75% (w/w), 0.28 % (w/w), and 0.14% (w/w), respectively, in the formulation. The method was validated for specificity, linearity, precision, repeatability, and accuracy. Calibration plots were linear in the concentration range 0.5–6.0 µg per band for Gallic acid; 0.20–1.00 µg per band for Piperine, and 2.0–8.0 µg per band Withaferin A. The correlation coefficients were 0.990, 0.994, and 0.997 for Gallic acid, Piperine, and Withaferin A, respectively.
CONCLUSION
The method is simple, precise, specific, accurate, and economical. It can be used for routine analysis in formulations containing Amalaki , Pippali , and Ashwagandha .
Nutraceutical a term introduced in 1989 by Stephan De Felice has two words nutrition and pharmaceutical. The term executes nutritional as well as pharmaceutical properties and hence useful in management of chronic disorders. Awareness about nutritious as well as healthy diet among general public has revolutionized the need for nutraceuticals. Though the deaths due to malnutrition status have been successfully reduced by the green revolution and the prevailing condition due to improper nutrition that deprives health is being managed still the surge of lifestyle disorders or Non-Communicable Diseases (NCD) such as obesity, diabetes, cancer, etc. is increasing in the India as well as across the world affecting the overall health scenario. Medicinal plants showcase multiple target strategy. Drugs like Shatavari (Asparagus Racemosus), Amla and Ashwagandha (Withania somnifera) have promosing potentials and gained popularity as nutraceuticals in very short span. They exhibit their potentials by boosting immunity, improving metabolism, anti-inflammatory action and disease inhibiting modes. The typical daily diet of Indian population includes types of leafy vegetables, spices, herbal delicacies, legumes, fruits and seeds which impart palliative, preventive and modulatory role as nutraceuticals in health maintenance alone or in synergistic combinations. Herbs like ginger, garlic, curcumin, cumin, cardamom and Tulsi are the traditional dietary ingredients and are rich in phytonutrients, carotenoids, phenols, polyphenols, alkaloids, flavonoids. Evidence of these being antioxidant, immune-modulators, memory enhancers and their revitalizing effect is also observed. They have been linked to reduce severity of many diseases, including cancer, Rheumatoid Arthritis, Cardiac ailments and other debilitating conditions, metabolic disorders, stroke etc.
In present scenario Ayurveda spread globally. Rasa Shastra &Bhaishajyakalpana is the most important branch of ayurveda.Rasa Shastra deals with the metallic and herbo mineral preparations with their types, occurrence, physical properties and organoleptic characteristics. According to Ayurveda the drugs used for promoting and preserving health, strength and longevity in a healthy person are called Rasayana. Chyawanprash is formulated by processing around 50 medicinal herbs including the main ingredient Amla (Indian gooseberry), which is the world's richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders as standard. The nished product has a fruit jam (Avleh) like consistency with sweet, sour and spicy (Katu) avor. Scientic exploration of Chyawanprash is warranted to understand its therapeutic efcacy in Covid Pandemic. Chyawanprashrasayan has also listed in ayurvedic treatment of Covid Protocol by Ayush ministry.Chyawanprash have a great property to increase immunity
The current research is being conducted on the formation of easy to carry health supplement, which can be consume at any time and convenient for all age groups. We are all too familiar with a well-known phrase "Chyawanprash" which is formed up of Indian gooseberries and various kinds of herbal ingredients. This new idea of forming therapeutic bars into the shape of chocolate is intended not only to increase product appeal among children, but also to mask the bitter taste of some commonly used herbs. Many herbal ingredients are used in this formulation, including Indian gooseberries, which are high in vitamin C. Therapeutic bar as a Immune system boosting or maintenance is becoming a top priority these days. In today's hectic schedule working men and women are not able to take proper nutrition, they can fulfil their nutrition demand to some extent by consuming this product at any place. The addition of sorghum and pearl millets makes this bar nutri-dense. It is intended to replenish depleted reserves of life force and to maintain stamina, strength, and vitality while delaying ageing process. As a result, the goal of this study is to create a completely herbal chyawanprash with excellent immunity boosting efficacy and a very appealing type of formulated bar.
Bamboo has been an integral part of the traditional medicinal system worldwide. Traditionally, almost every part of bamboo has been used for medicinal purposes to treat skin infections, joint pains, bleeding gums, injuries, fever, and many more. Pastes of tender bamboo shoots are applied to injuries and skin infections. Bamboo is used in Ayurveda for paralytic complaints, inflammatory disorders, and external skin disorders. Several bioactive compounds like phenols, phytosterols, and flavonoids are present in young bamboo shoots and leaves which have putative health benefits and show antioxidative, anti-bacterial, anti-fungal and anti-viral properties. Several drugs derived from plants are described in Ayurveda as possessing wound-healing properties. B. vulgaris is used for skin problems in Trinidad and Tobago. The tribes of Raisen, Madhya Pradesh use leaves and stems of bamboo to treat skin injuries topically. Several bamboo extracts of leaves and shoots show potential anti-bacterial, anti-inflammatory and wound-healing properties. Antioxidants have been reported to play a substantial role in improving the wound-healing process and protecting tissues against oxidative damage. Flavonoids are known to promote the wound-healing process due to their antimicrobial properties, which appear to be responsible for wound contraction and increased rate of epithelialisation. P. edulis leaf extract has shown a potential role in preventing inflammation in persistent inflammatory conditions. Ethanolic extract of D. asper leaves has shown antimicrobial and anti-diarrhoeagenic properties, which is an important clinical aspect in wound-healing. Diabetes mellitus-associated impaired wound-healing severely affects patients’ life quality, leading to prolonged hospitalisation and lower limb amputations. Herbal medicines and plant extracts are used by about 80% population around the world for primary health care as they show efficacy, safety, cultural acceptability, and lesser side effects. Natural accelerators of cutaneous tissue repair with simultaneous anti-inflammatory and antimicrobial activities are of great interest for various dermatological disorders, and bamboo is one of the potential plants.KeywordsBambooPhytochemicalsWound-healingTraditional medicineHerbalAntioxidantAnti-inflammatoryAntimicrobial
Bamboo is one of the most sustainable materials in nature due to its fast growth, rapid regeneration, outstanding mechanical properties, and applications in numerous industries. Latest technological advances have been allowing the plant to be studied and applied to exciting new projects. Being bamboo an icon of sustainable development, this book approaches the latest developments in the study of the plant, either as a natural resource or as a source of inspiration for more efficient designs. With the global urging demand for more sustainable practices, innovations in bamboo science and technology are key to the development of environmentally sound solutions.
Background
Infectious diseases have posed a major threat to human survival for centuries and can devastate entire populations. Recently, the global outbreak of COVID-19 has increased exponentially, affecting more than 200 countries and millions of lives since the fall of 2019, largely due to the ineffectiveness of existing antiviral therapies. WHO announced it a public health emergency of international concern. A significant waiting period in antiviral therapy hindered by the rapid evolution of severe acute respiratory syndrome-coronavirus-2 aggravated the situation ensuing imposition of strict laws (e.g., communal dissociation, international travel restrictions, and maintenance of hygiene) that would help in inhibiting further outspread of COVID-19. Ayurveda system of medicine offers a holistic approach to the COVID-19 pandemic.
Objective
This review aims to highlight the potential of medicinal herbs and Ayurvedic drugs as the remedial approach for viral diseases, such as COVID- 19.
Methods
We reviewed the literature from journal publication websites and electronic databases, such as Bentham, Science Direct, Pub Med, Scopus, USFDA, etc.
Results
The drugs used in the traditional system of medicine have the potential to prevent and cure the infected patient. Ayurvedic therapies are known for regulating immunity and rejuvenation properties that behold much promise in the management of COVID-19 disease. Government of India, Ministry of AYUSH recommends some precautionary fitness measures and an increase in immunity with special reference to respiratory health.
Conclusion
While there is no medication for COVID-19 as of now, taking preventive measures and boosting body immunity is highly recommended. A number of medicinal plants that play an important role in revitalizing the immune system are easily accessible in home remedies.
Now a days, immunity boosting or maintaining immunity system is becoming a first n most important priority. Hence goal of research is to prepare a completely herbal chyawanprash having excellent immunity boosting efficacy with a very attractive type of chocolate formulation. This new idea is making chyawanprash chocolate into the toffee shape is not only to increase attractiveness of product in children but also cover bitter test of some used herbals. In this formulation 35 herbal ingredients are used including amla as a prime ingredient which is enriched with vitamin c.
Objective:
Keratinocytes are the predominant cell type in the epidermis and play key roles in epidermal function. Thus, identification of the compounds that regulate the growth of keratinocytes is of importance. Here we searched for such compounds from the herbs used in traditional medicine Ayurveda.
Methods:
Human keratinocytes were cultured in the presence or absence of the herbal extracts for 2 weeks; the effect of the extracts on cell growth was determined by staining the cells with Coomassie brilliant blue. To detect the compounds that regulate the growth of keratinocytes, the herbal extracts were subjected to high-performance liquid chromatography (HPLC).
Results:
We found that the extract of Emblica officinalis enhanced the growth of keratinocytes in culture. Further, we fractionated the extract of E. officinalis using HPLC and identified the fractions responsible for the enhanced growth of keratinocytes.
Conclusion:
The extract of E. officinalis enhanced the growth of human keratinocytes in culture. E. officinalis contains the compounds that would be beneficial for human skin health because enhanced growth of keratinocytes would promote wound healing.
ResearchGate has not been able to resolve any references for this publication.