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Abstract
We examined nine Chinese medicinal herbs, Salvia miltiorrhiza (Dan-shen), Ligusticum chuan-xiong (Chuan-xiong), Achyranthes bidentata (Niu-xi), Hosta plantaginea (Yu-zan), Hosta ventricosa (Zhi-yu-zan), Drynaria fortunei (Gu-shui-bu), Ophiopogon japonicus (Mai-men-dong), Clematis chinensis (Wei-lin-xian), Lycopodium clavatum (Shen-jin-cao) for their effects on orthodontic tooth movement in guinea-pigs and rabbits. Some drugs increased the rate of orthodontic tooth movement. Hosta ventricosa increased the rate of movement by 2.11 times, and Salvia miltiorrhizan, Ligusticum chuanxiong and Achyranthes bidentata by 1.6 times. Histological observations showed that the bone resorption on the pressure side of moving tooth was more obvious in those treated animals than in control animals. Besides, Hosta ventricosa and Drynaria fortunei invigorated the osteoblasts and caused more bone deposition on the tension side of moving tooth.
The structure of the bones of mice with and without consumption of Gusuibu extracts were compared. Twenty 8-week-old male BALB/c mice were divided into two groups. In the control group ten mice were daily fed a normal diet and distilled water for drinking. In the Gusuibu group ten mice were daily fed a normal diet and distilled water mixed with Gusuibu extract for drinking. The mice were kept for 5 weeks and were then killed. Using micro-computed tomography, 20 micro-tomographic slices with an increment of 0.25 mm were acquired to cover the proximal end of the left tibia of each mouse. Quantitative morphometry of the bone structure was performed. The results showed that consumption of Gusuibu extract increased the bone volume/tissue volume ratio by 6.45%. The bone trabeculae were increased by 10.00% in number so that the bone density was increased. To conclude, Gusuibu extract taken orally increased bone density.
Traditional Chinese medicines have been used in the Chinese population for the treatment of bone diseases and to promote bone healing for thousands of years. Some traditional Chinese medicines have shown therapeutic effects on fracture healing in clinical and animal studies. It is reasonable, therefore, to postulate that some traditional Chinese medicines somehow affect the process of bone metabolism and bone formation. The aim of this article is to review the bone forming effect of various traditional Chinese medicines.
We compared the amount of new bone produced by Gusuibu in collagen grafts to that produced by bone grafts and collagen grafts.
Twenty bone defects were created in the parietal bone of 14 New Zealand White rabbits. In the experimental group, 5 defects were grafted with Gusuibu extract mixed with absorbable collagen sponge, and 5 defects were grafted with autogenous endochondral bone. In the control groups, 5 defects were grafted with absorbable collagen sponge alone (active control) and 5 were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histologic assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 150 sections using image analysis.
A total of 24% and 90% more new bone were present in defects grafted with Gusuibu in collagen grafts than those grafted with bone and collagen, respectively. No bone was formed in the passive control group.
Gusuibu in collagen grafts have the effect of increased new bone formation locally and can be used as a bone graft material.
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