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Anti-Hyperglycemic Activity of Psidium guajava Bark Extract
Abstract
Objective: To evaluate the anti-hyperglycemic activity of water extract of Psidium guajava stem bark. Materials and methods: The water extract of stem bark of Psidium guajava was tested for its hypoglycemic activity in normal glucose loaded and alloxan-induced hyperglycemic Wistar rats. Blood glucose levels were evaluated at intervals of 30 and 90 minutes in normal glucose loaded animals, at intervals of 0, 1 and 3 h in acute study and at days 1, 3, 7 and 10 during sub acute treatment after extract administration at an oral dose of 250 mg/kg. Results: During both acute and sub-acute tests, the water extract showed statistically significant and considerable anti-hyperglycemic activity and enhanced glucose tolerance in normal glucose loaded rats. Conclusion: Psidium guajava stem bark possessed statistically significant anti-hyperglycemic potential in alloxan induced diabetic rats and enhanced glucose tolerance in glucose loaded normal rats.
... Guava leaf "P. guajava L." of the Myrtaceae family has a long history of medicinal uses in Egypt and worldwide as a treatment against hypertension, corpulence, and in the control of diabetes mellitus [100]. During the screening of a few plants, the leaves of P. guajava repress the plasma sugar level in alloxan-induced diabetic rats amid glucose tolerance test (GTT) [101]. ...
... This action was likewise seen by Mailoa et al. [130] with target drugs for the protein combination, cell divider union, and folic acid. Notwithstanding, the last did not discover the synergic impact with gentamicin, maybe because the season of maceration was lower than the time utilized by Betoni et al. [129] and the solvent was different Ahamad and Ansari [100], related the antimicrobial action against a few microorganisms and parasites with five flavonoids separated from the clears out. This action was likewise identified with the convergence of tannins in the takes off [131] and to the content of gallic acid and catechin [128]. ...
Psidium guajava is an important food crop and medicinal plant available in tropical and subtropical countries. P. guajava (Guava), belonging to the family of Myrtaceae. P. guajava Linn. (Guava) is used not only as food but also as folk medicine in subtropical areas around the world because of its pharmacologic activities. It contains important phytoconstituents such as tannins, triterpenes, flavonoid, quercetin, pentacyclic triterpenoid, guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta-sitosterol, uvaol, oleanolic acid, and ursolic acid. Conventionally, guava is used for the treatment of various ailments such as antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardioactive, anti-cough, antidiabetic, anti-inflammatory, and antinociceptive activities, supporting its traditional uses.
Objective: To study the effect of 50% ethanolic extract of Terminalia arjuna bark on glucose and lipid profile in serum, kidney, liver and adipose tissue in alloxan induced diabetic rats. Methods: Oral administ ration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan induced diabetic rats for a period of 30 days. Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, the extract even under high concentration (500 mg/kg body weight) showed no toxic effect in control rats. Conclusion: The study indicates that Terminalia arjuna 50 % ethanolic stem bark extract at both doses, 250 and 500 mg/kg body weight, restored all the lipids and glucose parameters to near normal values and the dose of 500 mg/kg body weight showed more effect.
The antidiabetic activity of Ethanol (95%) bark extract of Bauhinia variegata Linn. was evaluated in alloxan-induced diabetic rats. The various parameters like blood glucose, body weight, total cholesterol, triglycerides, high density lipoprotein, insulin, oral glucose tolerance test and histopathology of pancreas were studied. The results were found to be significant antidiabetic by reducing the blood glucose level, improving body weight, attenuating the altered lipid profile toward the normal and by regenerating the Islets of langerhans. Therefore the present study justifies that ethanol extract of Bauhinia variegata exhibits significant antidiabetic activity, so this extract may have Insulin-like properties.
The present study was aimed to evaluate the anti diabetic, antihyperlipidemic potential of Rubus racemosus in normal streptozotocin induced diabetic mellitus in albino rats. In normal rats, the methanolic extract of Rubus racemosus reduced the raised blood glucose level of hyperglycemic due to glucose load significantly. In STZ rats, treatment with methanolic extract of Rubus racemosus and Standard glibenclamide reduced the blood glucose, bilirubin, SGOT, SGPT, ALP levels increased total protein and restored the lipid profile. In addition acute toxicity study revealed that the methanolic extract of the plant may be considered relatively safe.
Insight of evidence that some complications of diabetes mellitus due to hyperglycemia, we investigated the effect of T. arjuna bark extract on serum, liver and kidney marker enzymes in alloxan - induced diabetic rats. T. arjuna was administered orally at a doses of 250 and 500 mg/kg body weight for 30 days, after which serum liver and kidney tissues were assayed for the degree of pathological changes by means of markers such as alkaline phosphatase (ALP), acid phosphatase (ACP), alanine amino transferase (ALT), aspartate amino transferase (AST) and lactate dehydrogenase (LDH) resulted in a significant reduction in serum and tissue of liver and kidney marker enzymes when compared with control rats T. arjuna at a dose of 500 mg/kg body weight exhibited higher efficacy.
Extracts of 5 Chinese and 3 Paraguayan medicinal plants were examined for their effects on the duration of the forced swimming-induced immobility in mice to evaluate their antidepressant activities. In the case of MeOH extracts, Ginseng Radix was the most active followed by Rosmarinus officinalis LINN. In the case of 30% EtOH extracts, the activities were in the decreasing order, Psidium guajava LINN., Rosmarinus officinalis LINN., Valerianae Radix and Zizyphi Fructus. Hot 30% EtOH extracts of Zizyphi Fructus and Theobroma cacao L. showed potent activities. The activities of EtOAc solubles of Psidium guajava LINN. and H2O solubles of Valerianae Radix at 100 mg/kg were comparable to that of imipramine at 20 mg/kg.