Objective: To assess the treatment effect of moving cupping therapy on nonspecific low back pain(NLBP). Method: Randomly divided 70 outpatients of NLBP into two groups among which one group as study group of 37 cases was treated with moving cupping therapy and another 33 cases control group was given dexibuprofen (one kind of nonsteroidal anti-inflammatory drugs, NSAIDs). For study group, a period of moving cupping therapy included 6-times moving cupping therapy in all (one time with two days) interval; For control group, dexibuprofen was prescribed 0.15g per oral and 3 times per day, and 12 days were as a course of treatment. Before and after a course of treatment using visual analog scale(VAS) and 36-Item Short Form(SF-36) assessed the degree of low back pain, the capability of daily activity, and the total state of heath. Result: 0n the whole, in two groups the changes of VAS index and SF-36 scores were both significantly improved(P<0.01), which indicated both moving cupping therapy and dexibuprofen alleviated nonspecific low back pain, and improve their total state of heath. However, in comparison with control group, the changes of VAS in study group index and SF-36 scores were more significant (P< 0.01), it demonstrated that the effect of moving cupping therapy on NLBP was better than that of dexibuprofen. Furthermore, the effective rate of study group was 91.9% that was much higher than 75.8% of control group, which also revealed that moving cupping therapy was more effective than dexibuprofen. Conclusion: Being a sort of economical and effective method, moving cupping therapy can alleviate or even cure NLBP, therefore it might be recommended to treat and prevent NLBP.