A phobia is an irrational, intense and persistent fear of certain situations, activities, things, animals, or people. The main symptom of this disorder is the excessive and unreasonable desire to avoid the feared stimulus. Trypanophobia is an extreme reaction of fear to the use of needles in any type of medical environment. While many people experience some degree of aversion to receiving a shot at the doctor's office, persons who suffer from trypanophobia tend to take on levels of anxiety that can result in the occurrence of a panic attack. This extreme aversion to needles can lead to serious health issues, as the phobia will motivate individuals to forego medical treatments and tests that involve the use of a need to inject medication or to take blood samples. Trypanophobia is a most common phobia. This is not a fear of any needle but a fear of needles used by medical practitioners. In the present article, we have concentrated on phobia as well as trypanophobia; symptoms, types, comorbidty and triggers as well as possible treatments associated with trypanophobia.The aim of present article is to provide in depth knowledge about clinical aspects of trypanophobia.