An experiment was conducted to determine the growth performance and feed utilization of two Clariid catfish and their hybrid reared under monoculture, duoculture and trioculture systems. The Clariid catfish were Clarias gariepinus, Heterobranchus longifilis and their hybrid (♀H. longifilis X ♂C. gariepinus). In the monoculture system, each of the species and their hybrid was cultured separately, in the duoculture system, there were combinations of C. gariepinus with H. longifilis; C. gariepinus with hybrid catfish; and H. longifilis with hybrid catfish In the trio culture system, all the two catfish species and their hybrid were cultured together. Fingerlings of mean weight 8.50±0.50g were stocked into 21 circular tanks of 40 liters in capacity at 18 fingerlings per tank. Fish were fed on twice daily at 09.00hour and 18.00hour on 35% crude protein at 3% of their total body weight. There was 50% exchange of water daily in all the culture systems. The results revealed that all the two species and their hybrid grew best under the monoculture, followed by duoculture and least in trioculture systems. Hybrid catfish had the best growth and feed utilization, followed by C. gariepinus and the least with H. longifillis, There were significant differences (p<0.05) in all the growth and feed utilization parameters of the two clariid species and their hybrid in all the culture systems expect in the duoculture of hybrid catfish which showed no significant (p>0.05) differences when cultured with either C.gariepinus or H. longifilis. C. gariepinus had better growth rate and feed utilization when cultured with hybrid catfish than when cultured with H.longifilis and vice verse.