The effects of intra muscular (IM) administration of quinine (Qu) on the seminal fluid analysis and testicular histology was studied. Thirty adult male Sprague-Dawley rats were randomly divided into five experimental groups (6 rats per group). Group 1 (control) were given clean drinking water and rat chow, group 2 were given intra-muscular (IM) quinine injection 10mg/kg body weight + water + rat chow. Group 3 and 4 were given, IM quinine 10mg/kg body weight + water + rat chow and graded proportions of extract of Telfairia occidentalis of 4.5g, and 6.0g, respectively. While Group 5 were given rat chow + water + 6.0g of Telfairia occidentalis. The results show a destruction in the testicular histology, decreased sperm count, activity and morphology of Group 2 administered with quinine only, which was statistically significant (P<0.05), and there was also a dose-dependent improvement in the parameters studied in the Group (3 and 4) given extract of Telfairia occidentalis. Group 5 did not show any Testicular destruction but showed an increase in sperm count, morphology and activity but was not statistically significant (P>0.05). This shows that Qu therapy has a destructive effect on the histology of testes and decreased the sperm count, activity and morphology but these effects could be reversed by the administration of extract of Telfairia occidentalis.