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Sensitive skin: Clinical experiences with a new line of topical products
Abstract
"Sensitive skin" is a term used to describe heightened skin sensitivity and a high incidence of adverse reactions to certain irritants. The more common skin irritants are environmental factors such as cold, wind, rain, sun and heat, detergents and certain skin care products. Sensitive skin is a very common condition and more than 40% of people say they have it. It appears as redness, swelling, itchy and dry irritation to the face. Individuals with sensitive skin have to use high-quality products to minimize the risk of skin complications. In this article the results from three clinical experiences in the treatment of sensitive skin with a new line of topical products (Rilastil Pelli Intolleranti: a detergent and two creams) are shown. The products forming Rilastil Pelli Intolleranti line were well tolerated and quickly relieved the symptoms of sensitive skin.
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Combined exposure to dry climatic conditions and local heat sources together with detergents represents a common workplace situation. These conditions may support the induction of chronic barrier disruption leading subsequently to irritant contact dermatitis (ICD).
To test the irritant and barrier disrupting properties of air flow at different temperatures and velocities.
Using noninvasive biophysical measurements such as transepidermal water loss (TEWL) (TM 210; Courage & Khazaka, Cologne, Germany) we assessed the effects of short-term exposure to air flow at different temperatures (24 degrees C and 43 degrees C) in combination with sodium lauryl sulphate (SLS) 0.5% on the skin of 20 healthy volunteers in a tandem repeated irritation test. Chromametry was used to control the accuracy of the SLS irritation model.
In our study air flow alone did not lead to a significant increase in TEWL values. Sequential treatment with air flow and SLS led to an impairment of barrier function and irritation stronger than that produced by SLS alone. The two different air flow temperatures led to different skin temperatures but had no influence on permeability barrier function.
Warm air flow has an additional effect on the SLS-induced barrier disruption in a tandem irritation test with sequential exposure to SLS/air flow. This combination is suspected to promote ICD in workplace and household situations, especially in short-term applications as tested in our model.
Skin care regimens using active ingredients that are recommended by physicians who treat mucocutaneous conditions including aging should become more focused on reversing and preventing chronic inflammation. This adjustment of therapeutic and preventive strategies is necessary because chronic inflammation appears strongly linked to many preventable and treatable skin diseases and conditions such as visible skin aging. Mucocutaneous inflammation as the final common pathway of many systemic and mucocutaneous diseases including extrinsic aging has been established at the molecular and cellular levels. The corollary to this strategy includes inhibition of primary activators of mucocutaneous inflammation such as stratum corneum permeability barrier disruption, blocking any pro-inflammatory environmental insult such as ultraviolet radiation, and quenching tissue responses to these insults. This review will present the scientific rationale substantiating the conclusion that chronic inflammation is the common denominator in many mucocutaneous pathophysiologic processes including extrinsic skin aging.