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Sumamed in the treatment of chlamidial infection in small bronchial tubes diseases at children
Abstract
It has been studied the effectiveness of macrolide azithromycin-Sumamed in the treatment of chlamidial infection in small bronchial tubes diseases at children. The ctudy involved 56 children aged 2 to 15 years. Of these, 17 children had chronic obliterative bronchiolitis, 39 patients were diagnosed with bronchial asthma. Given the identification of chlamidial infection in a diagnostically significant titres, previosly carried out by the inefficiency of antibacterial therpy in the treatment etiotropic was included sumamed. Conducted dynamic observation for 6 months showed that etiotropic sumamed therapy led to a marked positive effect in the clinical couse of disease. Immunomodulatory effect of sumamed manifested in a significant increase in phagocytic activity of granulosytes.
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The term "atypical" pneumonia has been used to differentiate infections caused by Chlamydia pneumoniae, Mycoplasma pneumoniae, Legionella, and other related organisms from pneumonia caused by classic bacteria, the prototype being Streptococcus pneumoniae. However, recent studies demonstrated that the clinical presentation of pneumonia due to atypical pathogens cannot readily be differentiated from those caused by "typical" bacteria. This is further complicated by the observation that coinfections with atypical pathogens and other bacteria are frequent. Nonetheless, the term "atypical" can be useful, as these organisms share a number of characteristics that separate them from "typical" bacteria. They are either obligate or facultative intracellular parasites that cannot be isolated using routine microbiologic methods. The most commonly used method of diagnosis of these infections is serology, which has significant limitations. Although C. pneumoniae is now recognized worldwide as a common cause of respiratory infections in adults and children, major gaps remain in our knowledge of the biology of this organism and how it causes disease, in major part due to the lack of readily available, standardized diagnostic methods.