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Abstract
Objective: To study the effect of dorsal penile nerve selective neurectomy on the sensitivity of the penile before and after surgery. Methods: The penile vibration thresholds of penils in 92 cases of patients with primary premature ejaculation who underwent the dorsal penile nerve selective neurectomy were detected before operation and a a month and 3 months fter operation. Results: The glans penis vibration thresholds (GPVT) was (0.048±0.015) μm before operation, (0.280±0.084) μm 1 month after operation, (0.282±0.081) μ m 3 months after operation; The penile shaft vibration thresholds (PSVT) was (0.061±;0.014) μ m before operation, (0.064±0.022) μ m 1 month after operation, (0.065±0.020) μ m 3 months after operation.Statistical analysis showed: (1)GPVT at a month after operation significantly higher than that before operation(P<0.05). (2)GPVT at 3 months after operation was significantly higher than before operation (P <0.05). (3)Between one month after operation and 3 months after operation non significant change was found in GPVT(P> 0.05). (4)No significant change was found in PSVT preoperative and postoperative (P> 0.05). Conclusion: 1, Detection of penile vibration thresholds is simple, noninvasive, quantitative, reproducible methods for dorsal penile nerve sensitivity of objective testing methods. 2, After dorsal penile nerve selective neurectomy ,the sensitivity of the glans penis decreased and the threshold level become higher. 3, Dorsal penile nerve selective neurectomy is safe and effective for the treatment of primary premature ejaculation.
Objectives:
To evaluate the efficacy of resiniferatoxin in the treatment of patients with lifelong premature ejaculation.
Methods:
A total of 41 outpatients (mean age 26.14 ± 4 years) with premature ejaculation completed the present study. They were randomly separated into the resiniferatoxin group and the placebo group. The resiniferatoxin group included 11 patients with redundant prepuce and 10 patients without redundant prepuce, whereas the placebo group contained 10 patients with redundant prepuce and 10 patients without. For the treatment, the glans were respectively soaked in 30 mL of resiniferatoxin with a concentration of 100 nmol/L or 10% alcohol solution for 30 min before sexual intercourse. Clinical efficacy was assessed by using the Chinese Index of Sexual Function for Premature Ejaculation-5 and the intravaginal ejaculation latency time before or 4 weeks after the treatment. The side-effects were also evaluated.
Results:
In the resiniferatoxin group, the effective rate of patients with redundant prepuce was 63.6%, and both the intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 significantly increased (P < 0.05). However, the effective rate of patients without redundant prepuce was 20%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the resiniferatoxin treatment (P > 0.05). The total effective rate of patients treated with resiniferatoxin was 42.9%. In the placebo group, the effective rate of patients with or without redundant prepuce was 20% and 10%, respectively. The total effective rate of patients treated with placebo was 15%, and there were no significant changes of their intravaginal ejaculation latency time and Chinese Index of Sexual Function for Premature Ejaculation-5 before and after the placebo treatment (P > 0.05). The side-effects included a slight burning sensation for the glans penis and dysuria.
Conclusions:
These preliminary results show that resiniferatoxin might be suitable for treating patients with lifelong premature ejaculation and particularly those with redundant prepuce.
The hypothesis that premature ejaculators (PEs) are less able than non-premature ejaculators (NPEs) to evaluate accurately their level of physiologically determined sexual arousal was tested. Twenty-six men (13 PEs and 13 NPEs) viewed a variety of videotaped vignettes, some of which were excerpts from sexually explicit films. Concurrent subjective (self-report) and objective (plethysmograph) ratings of sexual arousal were taken. Data revealed that both the PEs and NPEs were equally accurate in assessing their level of physiological sexual arousal. These results and those from a sexual history questionnaire were used to evaluate several hypotheses regarding the nature and etiology of premature ejaculation.