Article

The anti-apoptotic activity of Psittacofulvin in transplanted hair bulbs

Authors:
  • International Hair Research Foundation
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Abstract

The anti-apoptotic activity of a new compound with a carotenoid-like structure was studied. This compound has been recently isolated chemically as a result of studies on the pigments present in a particular species parrots. This new class of pigment, which are also called Psittacofulvins, have been proved to possess interesting biological properties that differ from those that carotenoids are known to have. To evaluate the anti-apoptotic efficacy on dermal papilla of this compound we studied the effect on transplanted bulbs during hair transplants, like a model of induction of apoptosis of hair bulbs, because the evidence of the hair follicle damage during a transplantation is clear. We made a double blind randomized clinical trial on 50 men, volunteers, underwent an hair transplant (micro-mini grafts, FUE) in androgenic alopecia and treated with a topic solution with Psittacofulvin once a day, from 15 days before hair transplant to 90 days after transplantation. To study the effect of Psittacofulvin we used an experimental design evaluating: 1) the number of apoptotic fragments; 2) changes in the mitotic activity in the hair follicles before and after transplantation. Quantification of apoptotic fragments in transplanted hair follicles is a sensitive and accurate assay of hair follicle damage. Our results show a very important anti-apoptotic activity of Psittacofulvin in transplanted bulbs.

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... As there are no RCTs comparing hair surgery vs. no hair transplantation, only a level of evidence 2 can be attributed to the included studies comparing hair transplantation vs. hair transplantation with supportive therapies (two of the studies obtained a grade of evidence B, one study obtained a grade of evidence A2 and one study obtained a grade of evidence C). 81,[102][103][104] Efficacyfemales In female patients, there is lack of evidence concerning surgery with supportive therapies. We suggest that combination therapy may reduce further postoperative progression of AGA. ...
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