Newly diagnosed acute lymphoblastic leukemia (ALL) patients were randomly divided into Groups I-III; having 21, 20 and 21 patients each, respectively. Ten age, sex and socio-economically matched healthy subjects were included for reference. Blood samples were taken for hematological parameters. In all groups these procedures were repeated after every 0.5 month till 6 months (including first 3 months of completion of induction chemotherapy followed by maintenance therapy. Due to various reasons, 48 subjects (16 in each) completed the study and their data were analyzed. In conventional therapy (Group I), daunorubicin (1.5mg/kg,i/v weekly), vincristine (.4mg/kg i/v twice weekly) and prednisolone (5 mg/kg per day orally in 3 divided doses) were prescribed to patients of ALL as induction therapy for a period of 3 months. In Group II, L-asparaginase was administered in addition to Group I therapy in 100u/kg, i/m twice weekly dose. Powdered Nigella sativa seeds were given to Group III patients in addition to conventional therapy (without L-asparaginase) in 40 mg/kg orally in two equally divided doses. The data showed that prognosis was good in all groups and was similar in male and female. Remission rate (RR) was affected by increasing age and survival was better in younger patients. The prognosis was worse in patients with high (>50000/mm3) initial WBC counts. RR was negatively affected by severe anemia (Hb<8.0g/dl) which showed positive correlation with Hb level. ESR was markedly raised in majority of patients at presentation but remained high even after induction therapy. The RR and survival time were better in patients having blood ESR between 10 t o 100 mm/1st hr.