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... For this extract only a combination with Soy germ extract was investigated on pollakiuria in the night in elderly men with positive outcome. 11 Also an activity reduction of prostatic 5-a-reductase, with inhibiting effects on prostate tissue growth, was shown in vitro, as well as in an animal model (in vivo), for this extract. 12 However, for the health issue BPH there are no clinical data available on the pure extract using validated instruments like IPSS. ...
... For this extract only a combination with Soy germ extract was investigated on pollakiuria in the night in elderly men with positive outcome. 11 Also an activity reduction of prostatic 5-a-reductase, with inhibiting effects on prostate tissue growth, was shown in vitro, as well as in an animal model (in vivo), for this extract. 12 However, for the health issue BPH there are no clinical data available on the pure extract using validated instruments like IPSS. ...
Majority of men are affected by symptomatic benign prostatic hyperplasia (BPH) from a certain age. Botanical extracts are frequently used in the early management of the symptoms. In a single-arm, mono-center pilot study, the effects of a proprietary oil-free hydroethanolic pumpkin seed extract on the symptoms of BPH were investigated. A total of 60 men (62.3 years [95% confidence interval (CI): 60.3-64.3 years]) with a total International Prostate Symptom Score (IPSS) of 14.8 (95% CI: 13.5-16.1) participated between January 2017 and October 2017 in the study by ingesting the oil-free hydroethanolic pumpkin seed extract once daily before going to bed during 3 months. Change in IPSS within treatment period was assessed. Frequency of nocturia was recorded by bladder diary, and postvoid residual urine volume was determined through ultrasound. Between baseline and after 12 weeks of supplementation, a significant symptom reduction of an average 30.1% (95% CI: 23.1-37.1) was seen for the total IPSS. Symptom alleviation had a high impact on quality of life (P < .0001) and was significant after 8 and 12 weeks of intervention (P < .001). Nocturia significantly decreased over time (P < .0001), as confirmed by IPSS questionnaire and bladder diary. Postvoid residual urine volume was significantly reduced at the end of intervention (baseline: 83.67 mL [95% CI: 58.02-109.3]; after 12 weeks: 63.11 mL [95% CI: 45.37-80.85]; P = .0394). These results indicate that the oil-free hydroethanolic pumpkin seed extract seems to be a very well tolerable, appropriate plant extract to support health benefits in a collective suffering from BPH related symptoms without the need of medical treatment.
... Which may explain why it has been used in folk medicine to treat kidney, bladder and prostate disorders [27] Pumpkin seed oil has also been shown to improve symptoms of overactive bladder [28]. Pumpkin seed extract in combination with soybean extracts have been shown to have promising potential treat urinary tract complications including SUI, overactive bladder, frequency and nocturia [29][30][31][32]. This study differs in that it focused solely on urinary incontinence in perimenopausal women using a novel formula containing a soybean extract containing a high level of genistein in combination with a proprietary standardized pumpkin seed extract. ...
... Aqueous extracts of pumpkin seeds are used in folk medicine to treat urinary tract complications. Hydroethanolic pumpkin seed extracts showed promising activities on stress urinary incontinence, on urination frequency and on nocturia in clinical trials, which draw the research interest to the polar part, instead of the more well-known seed oil [1][2][3][4]. ...
Pumpkin seeds have been known in folk medicine as remedy for kidney, bladder and prostate disorders since centuries. Nevertheless, pumpkin research provides insufficient data to back up traditional beliefs of ethnomedical practice. The bioactivity of a hydro-ethanolic extract of pumpkin seeds from the Styrian pumpkin, Cucurbita pepo L. subsp. Pepo var. styriaca, was investigated. As pumpkin seed extracts are standardized to cucurbitin, this compound was also tested. Transactivational activity was evaluated for human androgen receptor, estrogen receptor and progesterone receptor with in vitro yeast assays. Cell viability tests with prostate cancer cells, breast cancer cells, colorectal adenocarcinoma cells and a hyperplastic cell line from benign prostate hyperplasia tissue were performed. As model for non-hyperplastic cells, effects on cell viability were tested with a human dermal fibroblast cell line (HDF-5). No transactivational activity was found for human androgen receptor, estrogen receptor and progesterone receptor, for both, extract and cucurbitin. A cell growth inhibition of ~ 40–50% was observed for all cell lines, with the exception of HDF-5, which showed with ~ 20% much lower cell growth inhibition. Given the receptor status of some cell lines, a steroid-hormone receptor independent growth inhibiting effect can be assumed. The cell growth inhibition for fast growing cells together with the cell growth inhibition of prostate-, breast- and colon cancer cells corroborates the ethnomedical use of pumpkin seeds for a treatment of benign prostate hyperplasia. Moreover, due to the lack of androgenic activity, pumpkin seed applications can be regarded as safe for the prostate.
Aims
Nocturia, or waking up at night to void, is a highly prevalent and bothersome symptom. Currently, there is a lack of clear and consistent recommendations regarding evaluation and management of nocturia. The aim of this report is to discuss how to fill the gaps in our knowledge in order to develop a practical patient‐oriented diagnostic and therapeutic algorithm for nocturia.
Methods
This paper is a report of the presentations and subsequent discussion of a Think Tank session at the annual International Consultation on Incontinence Research Society (ICI‐RS) in June 2017 in Bristol.
Results and Conclusion
Further investigations are needed to better understand the pathophysiology of nocturia, to allow improvement in diagnosis, and to optimize treatment by increasing efficacy and reducing adverse events. Patient‐oriented practical guidelines on nocturia are needed to help clinicians from different disciplines diagnose and treat nocturia.
Overactive bladder (OAB) has become an increasing field of interest. Traditional use indicates that pumpkin seed (Cucurbita pepo L.) may be helpful in combating its symptoms. Additionally, soy isoflavones (Glycine max) are well-documented for hormonal imbalance related indications. The present randomized, double-blind, placebo-controlled study evaluated efficacy and safety of Cucuflavone (containing extracts of pumpkin seed and soy germ) in 120 subjects suffering from OAB. After 12 weeks, subjects taking Cucuflavone experienced a significant reduction versus baseline, in (1) urination frequency, (2) urgency, (3) incontinence frequency, maximum urgency score, (5) nocturnal urination frequency and (6) OAB-symptom scale. The placebo group reached significant differences for (1), (3) and (6). No adverse events or abnormal changes in safety parameters occurred. Thus, the combination of pumpkin seed and soy germ extract can be used as natural alternative to relieve symptoms of OAB and to improve quality of life.
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