Renal cell cancer is one of the tenth most frequent tumor-dependent causes of death worldwide. In localized stages surgical therapy is the only curative option for the patient. If a renal cell carcinoma is diagnosed in late, i.e. advanced/metastasized stages a drug therapy with targeted agents following tumor burden surgery is nowadays the best option to increase patients progression-free survival. Whenever possible, a partial resection should be perform on regard to decrease rates of longtime renal failure.