Cosmetic / dermatologicol efficacy and skin compatibility of a dexpanthenol-containing foot cream

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The Dexpanthenol-containing* foot cream has been especially formulated to meet the special needs of people, who suffer from dry and sensitive skin. The foot cream is characterized by its very good moisturizing effect, while at the same time strengthening the skin's barrier. Thanks to the skin caring characteristics of the Dexpanthenol-containing foot cream the skin roughness as well as the skin scaling could be significantly alleviated and the callus skin was eliminated. Thus, the excellent caring properties, the good efficacy and very good skin compatibility resulted in a high consumer satisfaction and acceptance.

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... Another study evaluated the safety and efficacy of a foot cream containing dexpanthenol in volunteers with sensitive skin, and in combination with other active ingredients. Nonetheless, the cream contained other active ingredients, which make it impossible to evaluate panthenol's efficacy, and the products´ ability to reduce the symptoms associated with sensitive skin was not evaluated, since the assessment of the product's efficacy was restricted to measuring the reduction in skin roughness and scaling, as well as callus elimination [111]. ...
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Objective Sensitive skin is characterized by self-reported sensory perceptions in response to stimuli that should not provoke unpleasant sensations. Cosmetic products for sensitive skin are designed to minimize these symptoms. This study aims to unveil the most used active ingredients for sensitive skin in facial care products. Methods A pool of products whose label included the expressions “sensitive skin”, “reactive skin” or “intolerant skin” were analyzed. The active ingredients were identified from product compositions and ranked in descending order of occurrence. The scientific evidence regarding the mechanism of action and efficacy of each ingredient was also compiled. Results Eighty-eight products from 19 multinational brands were included. Niacinamide leads the top, followed by Avena sativa, allantoin, glycyrrhetinic acid and derivatives and Laminaria ochroleuca. Ingredients which can reduce skin inflammation and act on the skin barrier were used in more than half of the products analyzed. The clinical studies regarding the active ingredients used in these products remain sparse and lack methodological quality. Among the top ingredients, niacinamide, panthenol and acetyl dipeptide-1 cetyl ester were the only ones studied on volunteers having sensitive skin, while acetyl dipeptide-1 cetyl ester and palmitoyl tripeptide-8 were designed to act on the molecular targets involved in this condition. Conclusion This study reveals the most used active ingredients in cosmetic products for sensitive skin, as well as the scientific evidence supporting their efficacy and the mechanisms of action. This insight is meaningful for dermatologists and other health professionals to provide customized advice based on the symptomatology of individuals with sensitive skin, and for the formulation of cosmetic products and design of new active ingredients.
Eventual relationships between the vascular function and transepidermal water loss (TEWL), in vivo,have not been entirely explored. By promoting local perfusion alterations through a well-known challenge test, the'tourniquet-cuff occlusion' manoeuvre, the present study searches for other dynamical factors influencing the cutaneous barrier, further exploring the applicability of these flow-related variables in dermatological research. By applying the tourniquet-cuff manoeuvre to a group of healthy volunteers (n= 20), transcutaneous (tc)gases (pO2-pCO2), LDF (laser doppler flowmetry) and TEWL were considered as representing the dynamical aspects under study and measured non-invasively. An haemodynamical relationship between tcpO2 and LDF in the post-occlusive period was clearly identified, defining the autoregulatory index as a numerical descriptor of the local metabolic-flow adjustment under stress. TEWL was also significantly affected by the manoeuvre, especially during the post-occlusive period,although no significant relationships between TEWL and other tc variables could be found. The present findings seem to suggest that, under the present experimental conditions, local haemodynamics may also influence TEWL measurements and the skin barrier.
Dexpanthenol-containing creams have been widely used for treatment of lesions (superficial wounds) of the skin and mucous membranes. Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A. Coenzyme A catalyses early steps in the synthesis of fatty acids and sphingolipids which are of crucial importance for stratum corneum lipid bilayers and cell membrane integrity. In the present study, the effects were examined of a dexpanthenol-containing cream on skin barrier repair, stratum corneum hydration, skin roughness, and inflammation after sodium lauryl sulphate (SLS)-induced irritation. Irritation was induced by application of SLS in patch test chambers. The dexpanthenol-contaming cream or the vehicle were applied twice daily and barrier repair, hydration, roughness, and inflammation of the skin were determined by using biophysical methods. Significantly accelerated skin barrier repair was found in treatments with the dexpanthenol-containing cream (verum) compared with vehicle-treated (placebo) or untreated skin. Both verum and placebo showed an increase in stratum corneum hydration, but significantly more so with the dexpanthenol-containing cream. Both creams reduced skin roughness, but again the verum was superior. The dexpanthenol-containing cream significantly reduced skin redness as a sign of inflammation in contrast to the vehicle, which produced no effect. Treatment with a dexpanthenol-containing cream showed significantly enhanced skin barrier repair and stratum corneum hydration, while reducing skin roughness and inflammation.
Surface evaluation of living skin (SELS) is a new optical-photoanalytical process. Four important parameters, determining the surface structure of the skin (scaling, roughness, wrinkling status and smoothness) can be recorded simultaneously. At the same time, the image of the studied skin area can be used either directly or converted to colors chosen arbitrarily to represent different temperatures. The usefulness of the method is shown through examples of relevant influences on the skin surface and their effect on the SELS values, as well as by the results of comparative treatments of several weeks' duration. Constitutional, topical and age-dependent skin surface structures can also be recorded by means of this method.
In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures. Our results suggest that topical dexpanthenol formulated in either lipophilic vehicle stabilizes the skin barrier function.