Article

Trimethoprim-sulfamethoxazole for the treatment of tear staining syndrome in dogs

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Abstract

22 dogs (31 eyes) that had treated with trimedioprim-sulfamethoxazole for tear staining syndrome at Snoopy Pet Clinic from October 2000 to September 2002 were reviewed. Of the 22 dogs, 12 were female and 10 male. Their mean (± SD) age was 3.5 (± 1.3) years. The breeds of the dogs consisted of Maltese (8 dogs), Shih tzu (6 dogs), Poodle (5 dogs), Yorkshire terrier (2 dogs), and Mixed (1 dog). The dogs received 30 mg/kg trimethoprim-sulfamethoxazole perorally twice daily for two to six weeks. 26 (19 dogs) of the 31 eyes (22 dogs) recovered completely and did not show relapse at 26-30 weeks after treatment. Any complications did not observed. Five eyes of three dogs were not cured. Two eyes (one dogs) of them had not response to medicament and three eyes (two dogs) recurrence but the clinical signs decreased. It was considered that the trimethoprim-sulfamethoxazole was effective for the treatment in dogs with tear staining syndrome.

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Chapter
The value of the sulfonamides as single antimicrobial agents has been greatly diminished both by widespread acquired resistance and by their relatively low potency compared to more modern antimicrobial drugs. However, when combined with antibacterial diaminopyrimidines such as trimethoprim, resistance occurs less frequently and thus their usefulness has been enhanced. This chapter discusses the chemistry, mechanism of action, antimicrobial activity, resistance, pharmacokinetic properties, drug interactions, toxicity and adverse effects, administration and dosage, and clinical applications of sulfonamides, diaminopyrimidines, and their combinations. Diaminopyrimidines interfere with folic acid production by inhibition of dihydrofolate reductase. Some diaminopyrimidines have marked specificity for bacterial dihydrofloate reductases (aditoprim, baquiloprim, ormetoprim, trimethoprim), others for protozoal enzymes (pyrimethamine), and others for mammalian enzymes (methyltrexate). Some diaminopyrimidines such as pyrimethamine have high activity against protozoa by inhibiting dihydrofolate reductase and thus preventing purine synthesis. These drugs are used in the treatment of systemic protozoal infections.
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Article
The objectives of this study were to observe the effects of trimethoprim-sulfadiazine on equine tear production and to determine normal fluctuations in Schirmer tear test (STT) values in horses. A randomized, placebo-controlled, blinded clinical trial measuring STT values in 15 horses over an 8-week period was performed. The treatment group (eight horses) received 30 mg/kg trimethoprim-sulfadiazine orally once a day and the control group (seven horses) received placebo (flour) at the same time. All horses were housed outdoors throughout the study. Schirmer tear test values were measured at 0, 2, 4, 6 and 8 weeks, and 4 weeks after discontinuation of treatment. There were no significant differences in tear production between the treated and control groups. Fluctuations in STT were observed and may result from individual and environmental variations. Trimethoprim-sulfadiazine did not decrease tear production in the horses in this study. Horses normally experience periodic fluctuations in STT values.
Keratoconjunctivitis sicca in dogs associated with sulfonamide therapy: 16 cases (1980-90)
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  • 남치주 Tear
  • 서 눈물생산
  • 비루관 개통성
  • 굴곡도
서강문, 남치주. Tear staining syndrome이 있는 poodle에 서 눈물생산, 비루관 개통성 및 굴곡도. 대한수의학회지 1995; 35: 383-390.
Tear staining syndrome이 있는 poodle에서 누낭비강개구술의 효과
  • 권오경 서강문
서강문, 권오경, 남치주. Tear staining syndrome이 있는 poodle에서 누낭비강개구술의 효과. 한국임상수의학회지 1995; 12: 186-193.
Tear staining syndrome이 있는 poodle에 서 눈물생산, 비루관 개통성 및 굴곡도
  • 남치주 서강문
서강문, 남치주. Tear staining syndrome이 있는 poodle에 서 눈물생산, 비루관 개통성 및 굴곡도. 대한수의학회지 1995; 35: 383-390.