As to the technology requirements of electromagnetic compatibility and protection performance test for system, considering the problems existed in traditional electromagnetic susceptibility test method, we put forward an electromagnetic radiation safety margin test method combined injection with radiation. Considering the equal response voltage on the equipment input port as equivalent principle rather than the distributive current on the cable, the equivalence between injection and radiation was theoretically analyzed. By adopting antisymmetric directional coupler cascade design scheme, the S parameter of coupling module with six ports was calculated. Moreover, the effect test method of using injection as an equivalent substitute for radiation based on coupling module was put forward. The typical antenna receiving system was selected as equipment under test. By carrying out injection and radiation effect test, under the condition of equal output response, the curvilinear relation between radiated field intensity and injection voltage was determined. The validity of electromagnetic radiation safety margin test method combined injection with radiation was verified.