Article

Effect of aloe vera on animal models of parkinson disease in mice

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Abstract

Aloe vera (Family: Liliaceae) has been used for the treatment of diabetes, skin disorders and as anti-inflammatory agent. To evaluate the anti-parkinson effect, Rota rod and catalepsy bar models were used. Assessment of oxidative stress was done in the striatal region of the brain by malondialdehyde (MDA) and reduced glutathione (GSH) measurement. A. vera (200 and 400 mg/kg, p.o.) was found to significantly increase the retention time in rota rod test and significantly decrease the latency period in catalepsy bar test as compared to MPTP and haloperidol groups. A.vera was found to have significant anti-oxidative effect in the striatal region of the brain by MDA and GSH measurement. Histopathological analysis of brain tissue of A.vera treated groups revealed minimal neuronal destruction as compared to MPTP and haloperidol groups. Thus it can be proposed that A.vera has a potential anti-parkinson effect in mice.

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... An immunomodulatory study on rats showed that A. vera gel extract is taken orally at a dose of 200 and 400 mg/kg exhibiting significant phagocytic activity as compared with aspirin (Bhalsinge et al. 2018). A. vera extract revealed nerve protective activity by reducing the mitochondrial damage in the rat brain (Wang et al. 2010) and antiparkinson and antioxidant activities in mice (Bagewadi and Rathor 2014). ...
Chapter
The main goal of this chapter is to discuss the multiple usage of plants, one of which is its usage for medicinal and pharmaceutical applications besides their potential role in improving the environment. The chapter will be focusing on a few plants which have medicinal properties and potential pharmaceutical/industry applications. Generally, medicinal plants used for traditional medicine play a significant role in the healthcare of the majority of people in many developing countries. At the same time, those plants can play a bigger role in solving many environmental issues like the gradual conversion of habitable land used for agriculture into a desert and reduce the carbon footprint. In this chapter, we will be discussing and reviewing the major role of multiple usage of shrubs growing or potentially can be grown in arid and semi-arid areas such as jojoba, Aloe vera, Moringa and Acacia.
... Increased antioxidants activities and decreased levels of lipid peroxides were seen in the brains of mice pretreated with E.ganitrus convincingly demonstrated that the extract significantly reduces oxidative stress. Our study findings are in accordance with previous studies done by Reddy VVM et al [34] and Bagewadi HG et al [35]. It is also established that Flavonoids content in E.ganitrus leaves has marked antioxidant activity [36]. ...
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Elaeocarpus ganitrus (Family: Elaeocarpaceae), has shown beneficial role in the treatment of depression, convulsions and asthma. This study was undertaken to evaluate the antiparkinson effect of E.ganitrus. Materials and methods: Swiss albino mice of either sex were divided into 06 groups (n =12). 1st group mice were given 0.5% carboxy methyl cellulose (orally), 2nd group were administered MPTP (2 doses, each dose 20 mg/kg at 2 hr. interval, i.p.). Whereas 3rd, 4th and 5th groups - were administered with E. ganitrus (100, 200, and 400 mg/kg/day, orally), respectively, along with MPTP. Group 6- received Levodopa (30mg/kg, i.p,) along with MPTP. To evaluate anti-Parkinson effect, hanging wire test, tardive dyskinesia test and elevated plus maze test were performed on the1st day and on 8th day. One way ANOVA followed by post-hoc Tukey test, with p less than 0.05 was considered statistical significant. Results: E.ganitrus (200 and 400 mg/kg, p.o.) was found to increase the hanging time significantly (p less than 0.001) in hanging wire test and significantly decreased (p less than 0.001) the Vacuous Chewing Movements (VCMs) in tardive dyskinesia test as compared to MPTP group. E.ganitrus (200 and 400 mg/kg, p.o.) was found to significantly increase (p less than 0.001) the no. of entries and time spent in open arm and significantly decreased the no. of entries and time spent in closed arm (p less than 0.001) compared to MPTP treated group. Conclusion: The results of the present study conclusively showed that E.ganitrus has beneficial effect in MPTP induced experimental model of Parkinson's disease.
... Anxiety symptoms are very common in PD patients and some author's state that anxiety in PD can be manifested even before the emergence of the first motor symptoms [11,12]. Previous studies undertaken by us shows that A.vera possess antioxidative properties and showed beneficial effect in rotarod test and catalepsy bar tests which are behavioral models of Parkinson disease [13].The present study was undertaken in order to further strengthen the evidence of protective role of A.verain haloperidol induced parkinsonism in other animal models like-hanging wire, hole board and tardive dyskinesia test. ...
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Aloe vera (Family: Liliaceae) has been used for the treatment of diabetes, skin disorders and as an anti-inflammatory agent. There is increased concern about the side effects of conventional medicine in the treatment of Parkinson’s disease (PD). As A.vera has found to have antioxidative property, it may be a safer alternative. Methods: Parkinson’s disease was induced by administering haloperidol (1 mg/kg i.p. daily x 1 week).The mice of either sex were divided into 06 groups (n =12). 1 st day group mice were given distilled water (orally), 2nd group were administered haloperidol (20 mg/kg i.p.).The 3rd, 4th and 5th groups were administered A.vera (100, 200, and 400 mg/kg/day, orally) respectively, along with haloperidol. Group 6- received Levodopa (30mg/kg, i.p,) along with haloperidol. To evaluate anti-Parkinson effect, hanging wire test, tardive dyskinesia test and hole board test were performed on the1st day and 8th day. One way ANOVA was used to detect statistical significance followed by post-hoc Tukey test. Results: A.vera (200 and 400 mg/kg, p.o.) was found to increase the hanging time significantly (p LESS THAN 0.001) in hanging wire test and significantly decreased (p LASS THAN 0.001) the Vacuous Chewing Movements (VCMS) in tardive dyskinesia test as compared to haloperidol group. A.vera (200 and 400 mg/kg, p.o.) was found to significantly increase (p LASS THAN 0.001) the number of dips and no. of line crossings in hole board test when compared to haloperidol group. Conclusion: The results of the present study conclusively showed that A.vera has beneficial effect in haloperidol induced experimental model of Parkinson’s disease.
... Moreover, many pharmacological studies have reported improvements in learning, memory and cognitive function and Alzheimer disease following administration of Aloe extracts as indicated in ITM textbooks [85][86][87][88][89]. A potential anti-Parkinson's activity has also been reported for Aloe gel in mice [90]. Moreover, aqueous extract of Aloe leaf powder exhibited anticonvulsant properties in mice [91]. ...
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