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Table 1. Summary of Chemotherapeutic Protocols Used in Haematological Malignancies
This Table summarize chemotherapeutic agents used in haematology chemotherapy protocols that approved for use in hospital across the Avon, Somerset and Whilshire Cancer
Services by the Network Drug and Therapeutics committee.
Disorder
Protocol
Agents
Type/class
Activated by
Days
Dose
HALF
LIFE
(Hour)
Route
CYCLE
Day
DURATION
Cycle
Indolent lymphoproliferative disorder
Chlorambucil +/- Prednisolone
Chlorambucil
Alkylating agent
Glutathione S-transferase P
1-14
10mg
1.5
OP
28
6-8
CHOP
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
750mg/m2
3-12
IV
21
2-8
Doxorubicin
antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1
50mg/m2
20-48
IV
Vincristine
Vinka alkaloids
Cytochrome P450
1
1.4mg/m2
0.05-85
IV
COP
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
600mg/m2
3-12
IV
21
2-8
Oncovin (Vincristine)
Vinka alkaloids
Cytochrome P450
1
1.4mg/m2
0.05-85
IV
CVP
Cyclophosphamide
Alkylating agent
Cytochrome P450
1,8
750mg/m2
3-12
IV
21
2-8
Vincristine
Vinka alkaloids
Cytochrome P450
1,8
1.4mg/m2
0.05-85
IV
Dexa-BEAM
Carmustine
Alkylating agent
Cytochrome P450 (1A2)
2
60mg/m2
0.15-0.5
IV
21-28
2
Melphalan
Alkylating agent
Active
3
60mg/m2
1.5
IV
Cytarabine (Ara-C)
Antimetabolites
Active
4-7
100mg/m2
0.10
IV
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4 and 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
4-7
75mg/m2
4-11
IV
FAD
Fludarabine
Alkylating agent
Deoxycytidine kinase
1-3
25-40mg/m2
20
IV
28
3-6
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1
50mg/m2
20-48
IV
Fludarabine (single agent)
Fludarabine
Alkylating agent
Deoxycytidine kinase
1-5
25-40mg/m2
20
IV/OP
28
3-6
Fludarabine and
Cyclophophamide
Fludarabine
Alkylating agent
Deoxycytidine kinase
1-3
25mg/m2
20
IV
28
3-6
Cyclophosphamide
Alkylating agent
Cytochrome P450
1-3
250mg/m2
3-12
IV
FCR (OP)
Fludarabine
Alkylating agent
Deoxycytidine kinase
2-6
24mg/m2
20
OP
Cyclophosphamide
Alkylating agent
Cytochrome P450
2-6
150mg/m2
3-12
OP
28
6
Rituximab
Antibody
Active
1
375mg/m2
0.8
IV
FCR (IV)
Fludarabine
Alkylating agent
Deoxycytidine kinase
2-4
25mg/m2
20
IV
28
6
Cyclophosphamide
Alkylating agent
Cytochrome P450
2-4
250mg/m2
3-12
IV
Rituximab
Antibody
Active
1
375mg/m2
0.8
IV
FMD
Fludarabine
Alkylating agent
deoxycytidine kinase
2-3
25mg/m2
20
OP
28
3-6
Mitozantrone
Antimetabolites
Active
1
10mg/m2
75
IV
Dexamethasone
Antibody
Active
1
375mg/m2
36-54
IV
MCP
Mitozantrone
Antimetabolites
Active
1
12mg/m2
75
IV
28
6-8
chlorambucil
Alkylating agent
Glutathione S-transferase P
1-10
10mg
1.5
OP
MCD
Mitozantrone
Antimetabolites
Active
1
12mg/m2
75
IV
28
6-8
chlorambucil
Alkylating agent
Glutathione S-transferase P
1-10
10mg
1.5
OP
Dexamethasone
Antibody
Active
1-5
20mg
36-54
IV
Rituximab (single)
Rituximab
Antibody
Active
1,8,15,22
375mg/m2
0.8
IV
22
1
NICE TAG 216
Bendamustine
Alkylating agent
Cytochrome P450
1,2
100mg/m2
0.66-3
IV
28
6
Hairy
Cell
Leukae
mia
Chlorodeoxyadenosine
(Cladribine)
Cladribine/Litak
Antimetabolites
Deoxycytidine kinase
1-7
3.6 or 4.8
mg/m2
5.4
IV
7
1
Pentostatin
Pentostatin
Antimetabolites
Cytochrome P450
1
4mg/m2
5.7
IV
2
2
Mantle Cell Lymphoma
CHOP
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
750mg/m2
3-12
IV
21
2-8
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1
50mg/m2
20-48
IV
Vincristine
Vinka alkaloids
Cytochrome P450
1
1.4mg/m2
0.05-85
IV
Hyper-CVAD/MA
Cyclophosphamide
Alkylating agent
Cytochrome P450
1-3
300mg/m2
3-12
IV
21
8
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
4-5
50mg/m2
20-48
IV
Vincristine
Vinka alkaloids
Cytochrome P450
4,11
1.4mg/m2
0.05-85
IV
Dexamethasone
Antibody
Active
1-5
40mg
36-54
IV
Methotrexate
Antimetabolites
Aldehyde oxidase
1-2
1g/m2
3-15
IV
Cytarabine (Ara-C)
Antimetabolites
Active
2-3
3g/m2
0.10
IV
Aggressive Non-Hodgkin’s Lymphoma
CHOP
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
750mg/m2
3-12
IV
21
2-8
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1
50mg/m2
20-48
IV
Vincristine
Vinka alkaloids
Cytochrome P450
1
1.4mg/m2
0.05-85
IV
CHOP & Rituximab
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
750mg/m2
3-12
IV
21
2-8
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1
50mg/m2
20-48
IV
Vincristine
Vinka alkaloids
Cytochrome P450
1
1.4mg/m2
0.5-85
IV
Rituximab
Antibody
Active
1,8,15, 22
375mg/m2
0.8
IV
PMitCEBO
Mitoxantrone
Alkylating agent
Cytochrome P450 (2E1, 1B1 and 3A4)
1
7mg/m2
IV
14
4-8
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
300mg/m2
3-12
IV
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4 and 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
1
150mg/m2
4-11
IV
Bleomycin
Antibiotic
Bleomycin hydrolase
1
10,000
units/m2
1.9
IV
Vincristine
Vinka alkaloids
Active
8
1.4mg/m2
0.05-85
IV
Very
Aggressiv
CODOX-M/IVAC
Vincristine
Vinka alkaloids
Active
1
1.5mg/m2
0.05-85
IV
28
3-4
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
1
40mg/m2
20-48
IV
e Non-
Hodgkin’s
Lymphom
a
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
800mg/m2
3-12
IV
Cytarabine (Ara-C)
Antimetabolites
Active
3
70g/m2
0.10
IV
Methotrexate
Antimetabolites
Aldehyde oxidase
10
300g/m2
3-15
IV
Hodgkin’s DISEASE
ABVD
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1,15
25mg/m2
20-48
IV
28
3-4
Bleomycin
Antibiotic
Bleomycin hydrolase
1,15
10,000
units/m2
1.9
IV
Vinblastine
Vinca alkaloid
Cytochrome P450 (3A4 and 2D6)
1,15
6mg/m2
0.5-19
IV
Dacarbazine
Alkylating agent
Cytochrome P450 (1A1 and 1A2)
1 7 15
375mg/m2
5
IV
ChlVPP
Chlorambucil
Alkylating agent
Glutathione S-transferase P
1-14
6mg/m2
1.5
OP
28
6-8
Vinblastine
Vinca alkaloid
Cytochrome P450 (3A4 and 2D6)
1,8
6mg/m2
0.5-19
IV
Procarbazine
Alkylating agent
Xanthine dehydrogenase/oxidase
Cytochrome P450 (1B1)
1-14
100-
200mg/m2
0.1
OP
Stanford V
Mustine (Chlormethine)
Alkylating agent
Cytochrome P450
1,5,9
6mg/m2
0.15
IV
48
1
Doxorubicin
Antibiotic
Cytochrome P450 (3A4, 2D6, 2B6 and 1B1)
Carbonyl reductase {NADPH} 1,3
Alcohol dehydrogenase [NADP(+)]
Aldo-keto reductase (1C3)
NAD(P)H dehydrogenase [quinone] 1
Xanthine dehydrogenase/oxidase
1,3,5,7,9,1
1
25mg/m2
20-48
IV
Vinblastine
Vinca alkaloid
Cytochrome P450 (3A4 and 2D6)
1,3,5,7,9,1
1
6mg/m2
0.5-19
IV
Vincristine
Vinka alkaloids
Active
2,4,6,8,10,
12
1.4mg/m2
0.05-85
IV
Bleomycin
Antibiotic
Bleomycin hydrolase
2,4,6,8,
10,12
5,000
units/m2
1.9
IV
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4 and 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
3,7,11
60mg/m2
4-11
IV
Hodgkin's Disease/Aggressive
NHL Salvage
Cockle
(Oral
Palliative)
Lomustine
Alkylating agent
Cytochrome P450 (3A4 and 2D6)
1
80mg/m2
1.5-48
OP
21-28
As tolerated
Cyclophosphamide
Alkylating agent
Cytochrome P450
1
100mg/m2
3-12
OP
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4 and 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
1-10
50mg/m2
4-11
OP
DHAP
Dexamethasone
Antibody
Active
1-4
40mg
36-54
OP
21
28
Cisplatin
alkylating agents
Myeloperoxidase
Xanthine dehydrogenase/oxidase
Cytochrome P450 (4A11, 2C9, 2B6)
Prostaglandin G/H synthase 2
Arylamine N-acetyltransferase
1
100mg/m2
0.15-0.5
IV
Cytarabine (Ara-C)
Antimetabolites
Active
2
2mg/m2
0.10
IV
ESHAP
Cytarabine (Ara-C)
Antimetabolites
Active
1 or 5
2mg/m2
0.10
IV
21-28
2
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4 and 3A5)
UDP-glucuronosyltransferase 1-1
1-4
40mg/m2
4-11
IV
Myeloperoxidase
Cisplatin
Alkylating agents
Myeloperoxidase
Xanthine dehydrogenase/oxidase
Cytochrome P450 (4A11, 2C9, 2B6)
Prostaglandin G/H synthase 2
Arylamine N-acetyltransferase
1-4
25mg/m2
0.15-0.5
IV
FLuDAP
Dexamethasone
Antibody
Active
1-3
100mg
36-54
IV
21-28
2-6
Fludarabine
Alkylating agent
Deoxycytidine kinase
2,3
30mg/m2
20
IV
Cisplatin
Alkylating agents
Myeloperoxidase
Xanthine dehydrogenase/oxidase
Cytochrome P450 (4A11, 2C9, 2B6)
Prostaglandin G/H synthase 2
Arylamine N-acetyltransferase
2, 3
50mg/m2
0.15-0.5
IV
Cytarabine (Ara-C)
Antimetabolites
active
2,3
1g/m2
0.10
IV
IVE
Epirubicin
Antimetabolites
UDP-glucuronosyltransferase 2B7
Cytosolic phospholipase A2
1
50mg/m2
2-33
IV
21-28
2-6
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4, 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
1-3
200mg/m2
4-11
IV
Mesna
Antimetabolites
--
1-3
600mg/m2
0.36-8.3
IV
Mini-BEAM
Carmustine
Alkylating agent
Cytochrome P450 (1A2)
1
60mg/m2
IV
7
2-3
Cytarabine (Ara-C)
Antimetabolites
active
2,5
100mg/m2
0.15-0.5
IV
Etoposide
Enzyme inhibitor
Cytochrome P450 (3A4, 3A5)
UDP-glucuronosyltransferase 1-1
Myeloperoxidase
2-5
75mg/m2
4-11
IV
Melphalan
Alkylating agent
Active
3
30mg/m2
1.5
IV
(R)-GIFOX
Rituximab
Antibody
Active
0
375mg/m2
0.8
IV
14
2-3
Gemcitabine
Enzyme Inhibitors
Cytidine deaminase
Deoxycytidine kinase
1
1000mg/m2
42-94
IV
Oxaliplatin
Antimetabolites
Cytochrome P450 (1A1)
2
130mg/m2
0.43-
16.8
IV
Mesna
Antimetabolites
--
2
1g/m2
0.36-8.3
IV
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