Land-Use and Land-Cover Change (LUCC) is a core program supported by the International Geosphere-Biosphere Program (IGBP) and the International Human Dimensions Program on Global Environmental Change (IHDP). Analyzing anthropogenic influence impacting on LUCC is one of key frontier domains supported by IGBP and IHDP, which requires differentiating and analyzing impact by anthropogenic factors on LUCC, and tightly combining LUCC with social, political, and economic issues. LUCC reflects the most direct and most close relationship between humanity and nature in the interaction. It is a process of adjusting all kinds of land use constantly in order to meet the need of social and economic development, and give expression to the development tendency that humans utilize land to be working and living.Due to the effect of the restriction of the special natural conditions, resources and the environment system in a continental river basin in an arid zone are especially affected by anthropogenic influences. Some scholars pointed out that, if the effective strength of human activities exceeds 37%, the river surface runoff process shits from its natural state to giving priority to an anthropogenic disturbance, Therefore, affecting the middle and lower reaches of the oasis area size would directly impact on the process of the middle reaches of land -use and land-cover change. In order to understand the current problem of the land, we needed to identify the key human influencing factors, discuss its regulatory mechanism, and evaluate its effect on land -use and land-cover change, on basis of which we sought countermeasures to solve the problem. There are many attempts at related research on an anthropogenic driving effect on land -use and land-cover change by quantitative analysis. However, the anthropogenic influence during the course of basin scale land change has not been extensively researched.In order to investigate the driving effect by anthropogenic influence on land use and land cover change in the Heihe Middle Reaches, this paper took Ganzhou District as an example. First, this article analyzed the velocity and amplitude of various land use types and a comprehensive index of LUCC in the study area under anthropogenic influence from the year 2002 to 2011. Secondly, based on specifying the trend of various types of land use change, this article established a humanistic factors index system, and simulated multiple linear relationships between humanities factors and LUCC. Finally, it extracted key humanity factors that affected different land use types through Grey Relational Analysis. The results of the analysis were as follows: 1) In the overall structure of land use/cover of the Ganzhou area from 2002 to 2011, construction land expanded at an accelerating pace, agricultural land resources were being reduced, and the non-agricultural trend of land use structure was evident. 2) Population, poverty and wealth conditions, social economy, technology, policy and cultural concepts resulted in resultant forces to promote regional land use/cover change. The contribution rates of different anthropogenic influences were different in the process of land use change of different types. 3) Using a grey correlation analysis method in the evaluation index system, we found that the agricultural population declined, agricultural science and technology personnel rose, and the amount of motor-pumped well electricity continuing to grow were the dominant cultural factors index respectively to the change of urban and rural construction land, transportation and water conservancy, construction land and cultivated land in 2002-2011.