Article

Apple consumption helps to prevent cardiovascular diseases and cancer: Epidemiology and mode of action

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Abstract

Consumption of fruit and vegetables has the potential to reduce non transmissible diseases (NTD), such as cardiovascular diseases (CVD) and cancer, which are major public health concerns. Chile is a major apple producer and exporter in the world. Its production is concentrated in the sixth (O'Higgings) and seventh (Maule) regions of Central Chile. Phenolics and flavonoids are responsible for apple's high antioxidant activity. Many epidemiologic studies have shown that a diet rich in apples can reduce cardiovascular events (myocardial infarct and stroke) and some type of cancers. The mechanisms involved are not well understood. Nevertheless, antioxidants are keyplayers. Some of their in-vitro activities are inhibition of low-density lipoprotein (LDL) oxidation, cholesterol levels reduction, endothelium protection, reduction of neoplastic cells proliferation and apoptosis activation. As a consequence, daily apple consumption campaigns in the country should be implemented, as well as funding research focused on molecular mechanisms involved in its antioxidant activity.

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... C onsumption of fruit and vegetables has the potential to reduce nontransmissible diseases, such as cardiovascular diseases and cancer, which are major public health concerns (1)(2)(3). Many epidemiologic studies have shown that a diet rich in apples can reduce cardiovascular events (myocardial infarction and stroke) and some type of cancers (1). ...
... C onsumption of fruit and vegetables has the potential to reduce nontransmissible diseases, such as cardiovascular diseases and cancer, which are major public health concerns (1)(2)(3). Many epidemiologic studies have shown that a diet rich in apples can reduce cardiovascular events (myocardial infarction and stroke) and some type of cancers (1). Increased consumption of vegetables, particularly cruciferous ones, and fruits promote cardiovascular health and overall longevity (2). ...
... Our investigation shows that AA of the studied samples was highly correlated with their antiproliferative activity. It is well known that consumption of fruits and vegetables with high contents of bioactive compounds and high AA prevents and treats even the most dangerous diseases (1,(18)(19)(20). Dauchet et al. (3) revealed that consumption of fruit and vegetables is associated with a reduced rate of coronary heart disease (CHD) in observational cohorts. ...
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