Although the notion of sexual risk taking encompasses a number of potential problems related to human sexuality, it is most often used to describe the risks associated with acquiring sexually transmitted infections (STIs), including HIV. It has been well established that STIs often have negative consequences for reproductive and sexual health in both women and men from adolescence onward. An understanding of non-medical aspects of sexual risk taking is of crucial importance for the efficient prevention of STIs. The psychosocial dimension of sexual risks describes the individual and peerbased characteristics that influence sexual decision making and the probability of becoming infected with an STI. The socio-cultural dimension points to the existence of various ideological and moral expectations in a given society, which may increase or decrease vulnerability to sexual risk among different social groups or populations. Efficient prevention of STIs requires (a) knowledge of the medical aspects and a thorough understanding of non-medical aspects of sexual risks, (b) distinguishing between scientific facts and moralistic/ideological claims, and (c) interdisciplinary prevention programs, including the introduction of comprehensive sex education.