Article

Clinical analysis of aspiration pneumonia in respiratory intensive care unit

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Abstract

Objective: To analyze the clinical features, treatment and microbial etiology of the patients with aspiration pneumonia in respiratory intensive care unit (RICU). Methods: We retrospectively analyzed the data of 112 patients with aspiration pneumonia treated in the RICU of Zhongnan Hospital of Wuhan University. These data included clinical information, basic diseases and complications of the patients. Meanwhile, microbiologic tests, antimicrobial therapy and outcome of the patients were also included. Results: 86% patients with aspiration pneumonia in RICU were over the age of 65.The main underlying risk factor for aspiration pneumonia was cerebral hemorrhage/infarct (34%). All 112 patients had at least one basic disease, and 53% of the patients had four or more. 128 pathogens were isolated from 94 patients. Gram-negative bacilli (n=75) were the predominant organisms, followed by fungi (n=36). Many infections were mixed infection. The overall mortality was 43.8%. Conclusion: Aspiration pneumonia is more common in the old than in the young in RICU, with more complications, and prone to mix with the infection, the mortality is high. Teatment should lay stress on fungal infection. © 2015, Editorial Board of Medical Journal of Wuhan University. All right reserved.

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