Polydeoxyribonucleotide (PDRN) is used in aesthetic medicine as a skin revitalyzing agent as well as to correct depressed scars and striae distansae. The purpose of this study is to evaluate the effect of PDRN in stimulating skin biorevitalization of the face in women who underwent to a complete face-lift or a mini lifting procedure, not only to improve the cosmetic appearance but also to create more suitable conditions to better tolerate surgery. 15 female patients with an age ranging from 28 and 58 years (mean age 46) who had to undergo to a mini lifting procedure (10 patients) and a complete face-lift (5 patients) were treated in four sessions preoperatively, once a week, with intradermal administration of PDRN. Four more sessions, again on a weekly basis, were carried out starting from day 15 post-operatively. During the week before surgery and the two weeks following it, a home therapy consisting of one i.m. PDRN vial a day was offered to the patients. In all treated patients scar healing was normal, with no evidence of diastase and/or delayed scarring. Morevover the skin showed a good eutrophication and the suture stitches were removed a few days earlier than in the case of the traditional protocol (on day 10 instead of day 12). The patients' subjective evaluation was positive in all cases and extremely positive in 35% of them. The results of the study reveal a trophic and revitalizing action of PDRN on the skin which is therefore useful to improve the cosmetic appearance of the face and to create those conditions that assure a better tolerability of the stress due to surgery, and to reduce the healing time.