The anti-diabetic efficacy of bitter leaf (Vernonia amygdalina) leaf meal (VALM) was evaluated using broiler finishers'. Using 0%, 5%, 10% and 15% VALM representing diets A,B,C,D respectively to replace groundnut cake (GNC) in broiler finishers' feed, a total of 144 Marshal brooded broilers weighing 500-610g were used in a study that lasted for 28 days. The birds were divided into 4 groups of 36 birds each. Each treatment group was further infdivided into 3 replicates of 12 birds in a Completely Randomised Design (CRD). At the expiration of the experiment, 3 birds per treatment were randomly selected and bled for blood samples. The biochemical indices determined includes Glucose, Urea, Creatinine, Total protein and Globulin. The results indicated that the use of V. amygdalina did not significantly (P>0.05) affect the serum urea and creatinine of broiler birds. However, there was a significant (P<0.05) decrease in blood glucose of the chicken as the level of inclusion of VALM increases. Also significant (P<0.05) differences were observed in total protein and globulin of the birds. The percentage reduction of glucose were 14.30%, 22.90% and 28.60% for treatments B, C and D respectively. These results clearly indicate that the administration of V. amygdalina at varying levels produced hypoglycaemic effects. V. amaygdalina also did not seem to have adverse effect on the liver and kidney, since the serum urea and creatinine levels were not significantly altered. It could be inferred that V. amaygdalina besides exhibiting hypoglycaemic activity is also safe for consumption as food or medicine, since there were no indication of toxicity judging from the values of the biomolecules evaluated.