The health benefits of fruits have been exploited since ancient days. A healthy dietnot only keepsaway various chronic diseases and metabolic syndromes but also confersprotection from the undesirable side effects of drugs. Habitual consumption ofphytonutrient rich fruits and vegetablesis a potential strategy for the prevention or delayof various diseases. Berry fruits are rich in vitamins and antioxidant polyphenolics.Blueberries, in particular, are a rich source of antioxidant flavonoids, dietary fiber, traceelements, and vitamins. Their vast health-promoting potential includescardio-, neuro-,hepato-, and immuno-protection, makingthem a preferable dietary interventional choice.Moreover, research has reported that blueberry supplementation improved ocular health,offset macular degeneration, and reduced urinary tract infection. The healthbenefits andnutrient content in this superfruit is summarized in this chapter.