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Chemical constituents from Gymnosporia varialilis Loes.

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Abstract

Twenty-seven compounds were obtained from the 95% ethanolic extract of aerial part of Gymnosporia varialilis Loes, and identified as prinsepiol (1), (+) - pinoresinol (2), (-) - pinoresinol (3), (-) - syringaresinol (4), (+) - cycloolivil (5), (-) - olivil (6), 1 - hydroxypinoresinol (7), ilelatifol D (8), scopoletin (9), β - amyrin acetate (10), α - amyrin acetate (11), fupenzic acid (12), (+) - catechin (13), secoisolariciresinol (14), palmitate - 1 - raonoglyceride (15), phytol (16), caffeic acid (17), 3,4 - dimethoxycinnamic acid (18), (-) - massoniresinol (19), tanegool (20), β - sitosterol (21), lupeol (22), betulin (23), β - daucosterol (24), oleanolic acid (25), ursolic acid (26) and (-) - olivil monoacetate (27).

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... spinescens was reported. Our investigation on the aerial parts of this plant lead to the identification of a new coumarin, 7-hydroxy-4,6-dimethoxy-5-methylcoumarin (1), and 17 known compounds, including (E)-para-coumatic acid (2) [8], coniferaldehyde (3) [9], caffeic acid (4) [10], caffeic acid methyl eater (5) [11], ethyl caffeate (6) [12], ferulic acid (7) [17], isoferulic acid (8) [10], 4,7-dimethoxy-5-methylcoumarin (9) [14], 4,6,7-trimethoxy-5methylcoumarin (10) [14], (−)-secoisolariciresinol (11) [15], (+)-dihydrodehydrodiconiferyl alcohol (12) [16], dehydrodiconiferyl alcohol (13) [17], (+)-syringaresinal-4′-O-β-D-glucopyranoside (14) [18], 3, 3′,7-trihydroxy-4′,5-di-methoxyflavone (15) [19], 5-hydroxy-4-oxopentanoic acid (16) [20], 4carbonyl-5-hydroxy methyl valerate (17) [21] and daucosterol (18) (Figure 1). In addition, the antiangiogenic effects of all compounds were evaluated using a zebrafish model and none of them were bioactive in this assay. ...
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