ArticlePDF Available

Anti-ulcer activity of Ipomoea batatas tubers (sweet potato)

Authors:

Abstract and Figures

Background: Peptic ulcers occur in that part of the gastrointestinal tract which is exposed to gastric acid and pepsin, i.e., the stomach and duodenum. Gastric and duodenal ulcers are common pathologies that may be induced by a variety of factors such as stress, smoking and noxious agents including non-steroidal anti-inflammatory drugs. Ipomoea batatas tubers (sweet potato) contain ample amounts of antioxidants. It has been proven already by many scientific studies that antioxidants have ulcer healing properties. In reference to this, we tried assessing the ulcer healing effect of Ipomoea batatas tubers. Methods: The anti-ulcer activity of the tubers of Ipomoea batatas (sweet potato) was studied in cold stress and aspirin-induced gastric ulcers in Wistar rats. Methanolic extracts of Ipomoea batatas tubers (TE) at two doses, viz., 400 and 800 mg /kg were evaluated in cold stress and aspirin-induced gastric ulcer models using cimetidine and omeprazole respectively as standards. The standard drugs and the test drugs were administered orally for 7 days in the cold stressmodel and for 1 day in the aspirin-induced gastric ulcer model. Gastroprotective potential, status of the antioxidant enzymes {superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase(GR)} along with GSH, and lipid peroxidation were studied in both models. Results: The results of the present study showed that TE possessed gastroprotective activity as evidenced by its significant inhibition of mean ulcer score and ulcer index and a marked increase in GSH, SOD, CAT, GPx, and GR levels and reduction in lipid peroxidation in a dose dependant manner.Conclusion: The present experimental findings suggest that tubers of Ipomoea batatas may be useful for treating peptic ulcers.
Content may be subject to copyright.
A preview of the PDF is not available
... Thus, there is a continuous need to develop alternative solutions for gastric ulcers from natural resources that are both effective and safe. In particular, the use of anti-ulcer food supplements has received particular attention and has been reported to have protective effects against gastric ulcers [7][8][9][10]. ...
... Roots and tubers of sweet potato play an important role in many underdeveloped countries, ranking fifth in essential crops cultivated in over 115 nations [12]. The anti-ulcer effects of white sweet potato powder have been reported regarding the mechanism of wound healing and radical scavenging activities [9,13]. Its antioxidant and radical scavenging activities might be able to reduce the potential hazards against free radicals [14]. ...
Article
Full-text available
Ipomoea batatas (L.) Lam., Convolvulaceae is widely distributed in Asian areas from tropical to warm-temperature regions. Their tubers are known for their antioxidant, anti-bacterial, anti-diabetic, wound healing, anti-inflammatory, and anti-ulcer activities. The preventive and therapeutic effects of orange-fleshed sweet potato on gastric ulcers have not been investigated. In this study, the carotenoid extract (CE) of orange-fleshed sweet potato was found to protect against gastric ulcers induced by HCl/ethanol in mice. The anti-inflammatory and antioxidant activities of the carotenoid pigment extract were also evaluated as possible evidence of their protective effects. Administration of CE reduced gastric ulcers. Oral administration of CE (100 mg/kg) protected against gastric ulcers by 78.1%, similar to the positive control, sucralfate (77.5%). CE showed potent reducing power and decreased nitric oxide production in a mouse macrophage cell line, RAW 264.7, in a concentration-dependent manner. The production of the inflammatory cytokine interleukin-6 and prostaglandin E2 was also reduced by CE in a dose-dependent manner. The high carotenoid content of orange-fleshed sweet potato could play a role in its protective effect against gastric ulcers. This result suggests the possibility of developing functional products using this nutrient-fortified material.
... As high as 80% of the world population depends on plant-derived medicines for the first line of primary health care (Panda & Sonkamble 2012). The fruit of Persea americana is commonly referred to as avocado pear, alligator pear and butter fruit (Morton, 1987). ...
... Thus, the increase in acid secretion is a consequence of acetylcholine action on the histamine cell and parietal cell activity. Stress-induced ulcers also involve damage by reactive oxygen species (ROS) apart from acid and pepsin related factors (39). The anti-ulcerative effect of SPJ against cold stress induced ulcer in rats appears to be related to the inhibition of lipid peroxidative processes and to the prevention of GSH depletion. ...
Article
Full-text available
In Europe, use of potatoes (Solani tuberosi tuberecens) is a traditional remedy for stomach complaints. But in Egypt, uses of sweet potato (Batata) juice as a functional juice relieve acid reflux and dyspepsia. We performed a pilot study on the effectiveness and tolerability of freshly squeezed Batata juice in patients suffering from dyspeptic symptoms. Results production of Batata juice by thermal and pasteurization methods indicated that the Total chlorophyll (Chl.A and Chl.B), total carotenoids, antioxidant activity-DPPH, total phenols and vitamin C were decreased in pasteurized Batata juice compared with fresh Batata juice. After informed written consent, a total of 12 male subjects with various dyspeptic symptoms were enrolled, to drink about 100 ml of juice two times per day and whenever dyspeptic symptoms appeared for two weeks. Validated outcome measures included the gastrointestinal symptom (GIS) profile, a disease-specific health assessment questionnaire (QOLRAD). The GIS profile showed a high significant improvement in symptoms especially for nausea (3.2 ± 0.09) to (2.3 ± 0.87), abdominal cramps (2.9 ± 08) to (2.3 ± 0.7), heart burn (2.9 ± 0.78) to (1.5 ± 1.0) and retrosternal discomfort (2.8± 0.6) to (2.5 ± 0.6). Episodes of sickness, vomiting, bloating, epigastric pain, loss of appetite and early satiety were also significantly improved.
... An example of such raw plant materials is the sweet potato (Ipomoea batatas (L.) Lam., Convolvulaceae family), whose tubers contain many beneficial phytochemicals, including carotenoids, minerals (zinc, potassium, sodium, manganese, calcium, magnesium, and iron), vitamins (vitamin A, B6, C, K), phenolic acids, flavonoids, anthocyanin, terpenoids, tannins, saponins, glycosides, alkaloids, and steroids (Sun et al., 2019;Krochmal-Marczak et al., 2014;Ayeleso et al., 2016). Although the sweet potato is not widely known as a medicinal plant, some studies have demonstrated its beneficial effects on the prevention or treatment of chronic diseases due to antioxidant, anti-inflammatory, antilipogenic, immunomodulatory, anticancer, antiulcer, and antimicrobial activities it exhibits (Tang et al., 2015;Ji et al., 2015;Li et al., 2013;Sugata et al., 2015;Mbaeyi-Nwaoha and Emejulu, 2013;Panda and Sonkamble, 2012). However, the studies on the potato protective effect on the skin cells are scarce. ...
Article
Full-text available
Objective New raw materials are still being sought that could nurture the skin and protect it against various harmful factors, including free radicals responsible for ageing processes, cell mutagenesis and formation of cancerous lesions. Although the sweet potato (Ipomoea batatas (L.) Lam.) is not widely known as a medicinal plant, the available study findings suggest its multidirectional, health relevant properties, including anti-inflammatory, immunomodulatory, antimutagenic, and antimicrobial activities, as well as anticancer potential. However, the data on its antitirosinase and protective effects on skin cells are rather limited. Methods Our study evaluated the phenolic content, antioxidant, and antityrosinase activities, as well as cytotoxic effects of the extracts obtained from three sweet potato cultivars ('Beauregard', 'Purple' and 'Carmen Rubin') on two human cell lines - keratinocytes (HaCaT) and fibroblasts (BJ). Results The results evidenced that the cultivar characterized by the strongest antioxidant properties as well as the positive effect on the vitality of skin cells is the ‘Beauregard’ cultivar. Our findings showed that all three types of sweet potato extracts were tyrosinase inhibitors, yet their inhibitory capacities differed significantly. Conclusions Sweet potatoes can be considered a reservoir of biologically active substances with beneficial health properties.
... A number of experimental studies have been done on the relationship between plant extracts and their antiulcer activity on animal models. Among these medicinal plant, I. batatas [12], A. vera [13], A. integrifolia [14], C. colocynthis [15], G. glabraon [16], Swietenia mahagoni [17], and F. religiosa [18] have been reported with antiulcer activity. ...
Article
Full-text available
Introduction: The stem bark of Ficus thonningii is used by Ethiopian traditional healers and the community for the treatment of peptic ulcer disease. Thus, the current study was aimed at evaluating the antiulcer effect of hydro-methanol extract and solvent fractions of F. thonningii. Methods: The stem bark of F. thonningii was collected and shed dried. Then, the stem bark was extracted by 80% hydro-methanol solvents and dried. The part of the dried hydro-methanol extract was further fractionated with n-hexane, chloroform, and distilled water. Dose-dependent pylorus ligation, curative indomethacin-induced, and time-dependent ethanol-induced ulcer models were evaluated for the hydro-methanol extract and solvent fractions. Statistical analysis was done by using the Statistical Package for the Social Sciences (SPSS) version 24. The analyses were carried out using one-way analysis of variance (ANOVA), followed by Tukey's multiple comparison tests. The result was considered significant when p < 0.05. Results: The extract of F. thonningii showed a significant (p < 0.001) reduction in total acidity at all the tested doses (100, 200, and 400 mg/kg). All the tested doses of the hydro-methanol extract significantly reduced the gastric volume as compared to the vehicle (NC) (p < 0.01). The gastric pH was significantly (p < 0.05) increased by 200 and 400 mg/kg. Similarly, 200 mg/kg and 400 mg/kg significantly (p < 0.05) lowered gastric ulceration as compared to the NC. The hydro-methanol extract and aqueous fractions of F. thonningii at 200 mg/kg showed significant (p < 0.05) reduction in the ulcer index on a repeated dose of the hydro-methanol and solvent fractions. Ulcer healing effect on indomethacin-induced ulcer was not significant (p > 0.05) for all tested doses of the hydro-methanol extract. Conclusion: The study demonstrated that the stem bark of F. thonningii has a potential antiulcer activity that might be due to antisecretory or cytoprotective effects.
Chapter
Full-text available
Sweetpotato [sweet potato; Ipomoea batatas (L.) Lam.] is the seventh most valued food crop of the world. It has an inherent ability to grow under diverse agro-ecological and microclimatic zones ranging from tropical and subtropical zones to temperate areas with its tuberous roots enriched with the secondary metabolites of immense nutritional value. Among these, carotenoids are the most conspicuous one for having their use in nutritional, pharmaceutical, food, feed, aquaculture, and cosmetic industries. In food industries, carotenoids are used as food additives being antioxidants with attractive colors. Despite the immense economic importance, sweetpotato has received lesser attention in terms of its breeding with improved varieties. The conventional method of breeding by crossing has not been much successful due to the complexity of genome sterility and cross-incompatibility. Hence, the modern molecular breeding approaches, e.g. genetic, genomic, and metabolic (pathway) engineering, have been applied to this crop by some of researchers in Japan, Korea, and China to generate various cultivars with improved quantities and qualities of carotenoids. This has also opened a new gate for molecular breeders to engineer new sweetpotato cultivars enriched with carotenoids under current global scenario of dramatically rising climatic changes where novel food resources are bitterly needed, especially under alarmingly growing world population, the majority of which suffers from malnutrition.
Chapter
Plant extracts have been used for thousands of years because of higher bioactive components, which are responsible for certain physiological activities in human body. Numerous phytochemicals exist in edible fruits, flowers, seeds, and leaves, which are related to health-promoting benefits like antioxidants, antiinflammatory, anticancer, hypoglycemic, antiobesity, and substances with protective properties of the neurological, hepatic, cardio, and gastro systems. Chemical components present in them have physiological functions in living plants, and hence they have superior compatibility with human body. Various examples of animal model studies are also discussed to show the potency of the plant extracts against several ailments. Overall, the existing evidence proves that, while there are suggestions of the probable values of plant extract consumption, additional studies on humans are required to verify a factual cause-effect. As the technology develops and our understandings on the mode of actions of such molecules increase, new applications will emerge.
Book
Career GuideBook on Pharma
Article
Background: Plants form the basis of African traditional medicine which has contributed to significantly to the reduction of mortality, morbidity and disability due to many diseases. Medicinal plants have been reported to be an essential aspect oral health delivery cutting across all facets of oral health care. Method: Publications and reports on the use of African traditional medicine in oral health care were reviewed from published scientific journals, books, reports from national, regional and international organizations, research theses, conference papers and other grey material. International online databases such as MEDLINE, Science Direct, Scopus and Google were also searched up to 2015. Publications were limited to the English and French language Results: This review identified medicinal plant use by traditional healers in preventive, therapeutic and surgical aspects in the oral health and also identified some research gaps which further studies should be carried out. Conclusion: Medicinal plants has enormous benefits in the management of oral diseases but faces some challenges like toxicity, processing and follow-ups. Research on medicinal plants use in African traditional medicine in oral health is still scanty and most often incomplete.
Article
Full-text available
Extensive use of certain drugs, changes in lifestyles and food habits, as well as stress factors in modern human lives have led to an exponential increase in the incidence of gastric ulceration. The ideal anti-ulcer drug with less side effects and recurrence, and affordability has so far remains elusive, providing avenues for innovation, especially with phytochemicals. This review furnishes extensive information on the earlier works carried out in this area and rationalizes the mode of action of them, citing limitations of the previous studies. The primary aim was to cover different classes of potent natural compounds that have impressive gastro-protective property against various ulcerogens (except Helicobacter pylori infection), and are available in large quantities from the natural sorces. A few examples of synthetic congeners have also been included to highlight the type of innovation that may be required for developing new drugs.
Article
Full-text available
Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious diseases have been treated with herbals. The traditional medicine is increasingly solicited through the tradipractitioners and herbalists in the treatment of infectious diseases. Among the remedies used, plant drugs constitute an important part. A number of scientific investigations have highlighted the importance and the contribution of many plant families i.e. Asteraceae, Liliaceae, Apocynaceae, Solanaceae, Caesalpinaceae, Rutaceae, Piperaceae, Sapotaceae used as medicinal plants. Medicinal plants play a vital role for the development of new drugs (export and import diverse parts or bioactive compounds in the current market). The bioactive extract should be standardized on the basis of active compound. The bioactive extract should undergo limited safety studies.
Article
Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis and compounds that release nitric oxide have been useful pharmacological tools for evaluating the role of nitric oxide in gastrointestinal physiology and pathophysiology. Newer inhibitors with selectivity for one of the isoforms of nitric oxide synthase are even more powerful tools and may have utility as therapeutic agents. Also, agents that can scavenge nitric oxide or peroxynitrite are promising as drugs to prevent nitric oxide-associated tissue injury. Compounds that release nitric oxide in small amounts over a prolonged period of time may also be very useful for prevention of gastrointestinal injury associated with shock and with the use of drugs that have ulcerogenic effects. Indeed, the coupling of a nitric oxide-releasing moiety to nonsteroidal anti-inflammatory drugs has proven to be a valid means of substantially reducing the gastrointestinal toxicity of these drugs without decreasing their efficacy.
Article
Chlorophytum borivilianum belonging to family liliaceae is a very famous for its adaptogenic, immunomodulatory properties in traditional Indian system of ayurveda. In recent era there is a great thrust on screening of herbal extracts and formulations for Adaptogenic action as stress is a daily phenomenon faced by every human. The aim of the present study is to investigate the antistress activity of Aqueous and alcoholic tuber extracts of Chlorophytum borivilianum. This property is assessed by swim endurance stress, anorexic test in rats and despair swim test. Cold stress induced Gastric ulceration model was also selected to evaluate antiulcer activity. The effect of single oral dose of the extracts was evaluated at 30, 100 and 300 mg/kg. It was found that alcoholic extract significantly increases swimming time and reduces the ulcer index compared to that of control group. A significant effect (p< 0.001) from 200 mg/kg dose for both the extracts was observed in all four models.
Article
Garcinia indica Linn (Clusiaceae), a medicinal plant mentioned in Ayurveda has been used for treatment of liver disorders, dysentery, sunstroke, cancer and heart diseases. The present study was undertaken to investigate ulcer protective effect of aqueous and ethanolic extract of Garcinia indica Linn fruit rind. The aqueous and ethanol extract of Garcinia indica Linn were investigated for ulcer protective activity against indomethacin induced ulcerogenesis and HCl/ethanol induced gastric lesion. Oral administration of the aqueous and ethanol extracts of Garcinia indica fruit rind at the dose 500 mg/kg provided significant (p<0.001) reduction of ulcer index in the HCl/ethanol and indomethacin induced gastric lesion rat models.
Article
Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. In the western world, as the people are becoming aware of the potency and side effect of synthetic drugs, there is an increasing interest in the natural product remedies with a basic approach towards the nature. Throughout the history of mankind, many infectious diseases have been treated with herbals. A number of scientific investigations have highlighted the importance and the contribution of many plant families i.e. Asteraceae, Liliaceae, Apocynaceae, Solanaceae, Caesalpinaceae, Rutaceae, Piperaceae, Sapotaceae used as medicinal plants. Medicinal plants play a vital role for the development of new drugs. The bioactive extract should be standardized on the basis of active compound. The bioactive extract should undergo safety studies. Almost, 70% modern medicines in India are derived from natural products. Medicinal plants play a central role not only as traditional medicines but also as trade commodities, meeting the demand of distant markets. India has a very small share (1.6%) of this ever-growing global market. To compete with the growing market, there is urgency to expeditiously utilize and scientifically validate more medicinally useful plants.