The purpose of this investiagtion was to coordinate chiropractic treatment and muscular rehabilitation to facilitate treatment in female runners with sacroiliac subluxations. Sixteen female runners were diagnosed as having sacroiliac subluxation (SI group) through blind chiropractic screening. Four female distance runners were diagnosed as having no sacroiliac subluxation and/or lower back irregularities (control group). SI subjects underwent 12 sessions of chiropractic therapy followed by 6 weeks of a specialized muscular rehabilitation program. Exercise prescriptions were designed based upon individual subject requirements, chiropractic recommendations, and continued monitoring by the exercise physiologist and chiropractor. There was an average reduction in both pelvic elevation and lumbar assymmetry, as measured through pre- and posttreatment radiographs, of 1.2° and 3.4° (P < 0.05), respectively. Subsequent to the rehabilitation programs, all SI subjects had reinstated their preinjury training mileage. Five SI subjects reported personal records (PR) over the 10 km race distance, while two SI subjects recorded PR times for the marathon (42 km). In all cases, subjective symtomology was reported to have diminished appreciably. It was concluded that muscular rehabilitation programs prescribed in conjunction with prior chiropractic care, may provide an effective means of alleviating sacroiliac subluxation in female runners.