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Traditional and medicinal uses of Carica papaya

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Journal of Medicinal Plants Studies
Year : 2013, Volume : 1, Issue : 1
First page : (7) Last page : (15)
ISSN: 2320-3862
Online Available at
Journal of Medicinal Plants Studies
Vol. 1 No. 1 2013 Page | 7
Traditional and Medicinal Uses of Carica papaya
Aravind. G *1, Debjit Bhowmik 1 , Duraivel. S 1, Harish. G 1
1. Department of Pharmacognosy, Nimra College of Pharmacy, Vijayawada, Andhra Pradesh,
India (E-mail:
Papaya, botanical name
Carica papaya
, is an lozenge tropical fruit, often seen in orange
red, yellow
green and
yellow-orange hues, with a rich orange pulp. The fruit is not just delicious and healthy, but whole plant parts, fruit,
roots, bark, peel, seeds and pulp are also known to have medicinal properties. The many benefits of papaya owed
due to high content of Vitamins A, B and C, proteolytic enzymes like papain and chymopapain which have antiviral,
antifungal and antibacterial properties. Carica papaya can be used for treatment of a numerous diseases like warts,
corns, sinuses, eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation,
amenorrhoea, general debility, expel worms and stimulate reproductive organs and many, as a result Carica papaya
can be regarded as a Neutraceutical. The present article reviews the pharmacological uses of Carica papaya and
side/toxic effects. Carica papaya contains an enzyme known as papain which is present in the bark, leaves and fruit.
The milky juice is extracted, dried and used as a chewing gum for digestive problems, toothpaste and meat
tenderizers. It also contains many biological active compounds including chymopapain and papain which is the
ingredient that aids digestive system, and again used in treatment of arthritis.
Keyword: Carica Papaya, Papain, Chymopapain, Neutraceutical
1. Introduction:
Papaya is a powerhouse of nutrients and is
available throughout the year. It is a rich source
of threes powerful antioxidant vitamin C, vitamin
A and vitamin E; the minerals, magnesium and
potassium; the B vitamin pantothenic acid and
folate and fiber. In addition to all this, it contains
a digestive enzyme-papaintha effectively treats
causes of trauma, allergies and sports injuries. All
the nutrients of papaya as a whole improve
cardiovascular system, protect against heart
diseases, heart attacks, strokes and prevent colon
cancer. The fruit is an excellent source of beta
carotene that prevents damage caused by free
radicals that may cause some forms of cancer. It
is reported that it helps in the prevention of
diabetic heart disease. Papaya lowers high
cholesterol levels as it is a good source of fiber.
Papaya effectively treats and improves all types
of digestive and abdominal disorders. It is a
medicine for dyspepsia, hyperacidity, dysentery
and constipation. Papaya helps in the digestion of
proteins as it is a rich source of proteolytic
enzymes. Even papain-a digestive enzyme found
in papaya is extracted, dried as a powder and used
as an aid in digestion. Ripe fruit consumed
regularly helps in habitual constipation. It is also
reported that papaya prevents premature aging. It
may be that it works because a poor digestion
does not provide enough nutrients to our body.
The fruit is regarded as a remedy for abdominal
disorders, The skin of papaya works as a best
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Vol. 1 No. 1 2013 Page | 8
medicine for wounds. Even you can use the pulp
left after extracting the juice from papaya as
poultice on the wounds. The enzymes papain and
chymopapain and antioxidant nutrients found in
papaya have been found helpful in lowering
inflammation and healing burns. That is why
people with diseases( such as asthma, rheumatoid
arthritis, and osteoarthritis) that are worsened by
inflammation, find relief as the severity of the
condition reduces after taking all these nutrients.
Papaya contributes to a healthy immune system
by increasing your resistance to coughs and colds
because of its vitamin A and C contents. Papaya
included in your diet ensures a good supply of
vitamin A and C that are highly essential for
maintaining a good health. Carica papaya
constituents exhibit alkaline combination, as with
borax or potassium carbonate and they have
showed good results in treatment of warts, corns,
sinuses, eczema, cutaneous tubercles and other
hardness of the skin, and also injected into
indolent glandular tumors to promote their
absorption. Green fruits of papaya are used to
treat high blood pressure, dyspepsia, constipation,
amenorrhoea, general debility, expel worms and
stimulate reproductive organs.
2. Biological Sources
Botanical Name: Carica papaya
Family Name: Caricaceae
Common Name: Papaya, Paw Paw, Kates, Papaw
Part Used: Leaves, Fruits, bark, leaves
3. Nutritional Value
The papaya, papaw, or pawpaw is the fruit of the
plant Carica papaya, the only species in the genus
Carica of the plant family Caricaceae. It is native
to the tropics of the Americas. The papaya is a
large, tree-like plant, with a single stem growing
from 5 to 10 m (16 to 33 ft) tall, with spirally
arranged leaves confined to the top of the trunk.
The leaves are large, 50–70 cm in diameter,
deeply palmately lobed, with seven lobes. The
tree is usually unbranched, unless lopped. The
flowers appear on the axils of the leaves,
maturing into large fruit. The fruit is ripe when it
feels soft and its skin has attained amber to
orange hue.
These nutritional values of papaya help to prevent
the oxidation of cholesterol. Papaya is rich in iron
and calcium; a good source of vitamins A, B and
G and an excellent source of vitamin C (ascorbic
acid). The extracts of unripe C. papaya contain
terpenoids, alkaloids, flavonoids, carbohydrates,
glycosides, saponins, and steroids.
Table 1: Papaya, raw Nutritional value per 100 g
3 mg
Vitamin C
Folate (vit. B
Vitamin B
Niacin (vit. B
Riboflavin (vit.
Thiamine (vit.
) 0.04 mg
Vitamin A
Dietary fibre
Table 2: Carica papaya is a pack of enzymes
Carica papaya part
Unripe fruit
Β carotene,crytoxanthin
Benzyl isothiocynate, papaya oil
Ca, K, Mg,Zn,Mn,Fe
Shoots, leaves
Carpinine,carpaine,vitamin C and E
These nutritional values of papaya help to prevent
the oxidation of cholesterol. Papaya is rich in iron
and calcium; a good source of vitamins A, B and
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G and an excellent source of vitamin C (ascorbic
acid). The extracts of unripe C. papaya contain
terpenoids, alkaloids, flavonoids, carbohydrates,
glycosides, saponins, and steroids.
a. Proteolytic Enzymes
Papaya contains several unique protein-digesting
proteolytic enzymes including papain and
b. Papain
This enzyme is similar to pepsin, a digestive
enzyme in our body.
c. Chymopapain
A drug made from chymopapain used to be very
popular in treating slipped disk.
Both papain and chymopapain can help lower
inflammation and improve healing from burns.
d. Carpaine
The alkaloid, Carpaine, slows the heart rate in
humans and thus reduces blood pressure. Its
action is similar to the drug prescribed for heart
patients, digitalis. The alkaloid is reported to be
able to kill worms and amoebas.
e. Lycopene
Papaya has an abundance of cancer fighting
lycopene. It is a key intermediate in the
biosynthesis of many important carotenoids, such
as beta-carotene and xanthophylls.
f. Fibrin
Another useful compound not readily found in
the plant kingdom is Fibrin. It reduces the risk of
blood clots and improves the quality of blood
cells, optimizing the ability of blood to flow
through the circulatory system. Fibrin is also
important in preventing stoke.
4. Pharmacological Activity of Each Division
of Carica Papaya
Whole Carica papaya has a unique
pharmacological uses
4.1 Leaves
Papaya leaf has a numberless of benefits. In some
parts of Asia, the young leaves of the papaya are
steamed and eaten like spinach.
a. Dengue fever
Commencing on studies of Dr. Sanath Hettige,
who conducted the research on 70 dengue fever
patients, said papaya leaf juice helps increase
white blood cells and platelets, normalizes
clotting, and repairs the liver.
b. Cancer Cell Growth Inhibition
Recent research on papaya leaf tea extract has
demonstrated cancer cell growth inhibition. It
appears to boost the production of key signaling
molecules called Th1-type cytokines, which help
regulate the immune system.
c. Antimalarial and Antiplasmodial Activity
Papaya leaves are made into tea as a treatment for
malaria.[15] Antimalarial and antiplasmodial
activity has been noted in some preparations of
the plant,[15] but the mechanism is not understood
and not scientifically proven
d. Facilitate Digestion
The leaves of the papaya plants contain
chemical compounds of karpain, Substance which
kills microorganisms that often interfere with the
digestive function.
Additional Benefits of Papaya Leaves
As an acne medicine
Increase appetite
Ease menstrual pain
Meat tenderizer
Relieve nausea
4.2 Fruit
Papaya fruit is a rich source of nutrients such as
provitamin A carotenoids, vitamin C, B vitamins,
lycopene, dietary minerals and dietary fibre.
Danielone is a phytoalexin found in the papaya
fruit. This compound showed high antifungal
activity against Colletotrichum gloesporioides, a
pathogenic fungus of papaya
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a. Laxative
Ripe papaya fruit is laxative which assures of
regular bowel movement.
b. Indigestion
The milky juice which is tapped from the green,
mature fruit while still in the tree contains an
enzyme known as "papain". People use this in the
preparation of different remedies for indigestion.
c. Void the Heart Attack or Stroke
The folic acid found in papayas is needed for the
conversion of homocysteine into amino acids
such as cysteine or methionine. If unconverted,
homocysteine can directly damage blood vessel
walls, is considered a significant risk factor for a
heart attack or stroke.
4.3 Seeds
The black seeds of the papaya are edible and have
a sharp, spicy taste. They are sometimes ground
and used as a substitute for black pepper.
a. Nephro-Protective Activity
In wistar rats nephro-protective activity was
observed in dose related manner. Concentration
of urine and creatinine were evaluated.
b. More Potent
The papaya seeds are very pungent and peppery,
making them almost unpalatable. However the
seeds seem to have more potent medicinal values
than the flesh.
Papaya seeds have antibacterial properties and are
effective against E.coli, Salmonella and
Staphylococcus infections.
Papaya seeds may protect the kidneys from toxin-
induced kidney failure.
Papaya seeds can eliminate intestinal parasites.
Papaya seeds help detoxify the liver
As a skin irritant to lower fever
Cure for piles and typhoid
anti-helminthic and anti-amoebic properties
Dried papaya seeds actually look quite similar to
peppercorns and can be used in just the same
way. Grinding a couple over a meal, especially
protein rich meals, is a simple way to add extra
enzymes to your diet and improve your digestive
4.4 Peel
Papaya peel is often used in cosmetics. The
papaya peel can also be used in many home
a. Sunscreen And Soothing Slave
The presence of vitamin A helps to restore and
rebuild damaged skin. Applied papaya peel used
as skin lightening agent. When peel mixed with
honey and applied it can act as soothe and
moisturizers the skin.
b. Fight Dandruff
The papaya vinegar with lemon juice can be
applied to the scalp for 20 minutes prior to
shampooing to fight dandruff.
c. Muscle Relaxant
Adding papaya oil and vinegar to bath water,
along with essential oils like lavender, orange and
rosemary can be nourishing, refreshing and
relaxing, and can work as a pain reliever and
muscle relaxant.
4.5 Roots
Juice from papaya roots is used in some countries
of Asia to ease urinary troubles. Papaya leaf
when dried and cured like a cigar, is smoked by
asthmatic persons. An infusion of fresh papaya
leaves is used by person to expel or destroy
intestinal worms. Fresh young papaya are also
used to remedy colic, a certain stomach disorder
or cramp.
A decoction formed by boiling the outer part of
the roots of the papaya tree in the cure of
4.6 Latex
Fig 1: Fruits of Papaya
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The milky sap of a unripe papaya contains Papain
and chymopapain. chymopapain was approved
for intradiscal injection in patients with
documented herniated lumbar intervertebra discs
and who had not responded to "conservative
therapy". Vitamins and traces of an alkaloid
called Carpaine have also been found in the latex.
Apart from natural oils, the seeds of the fruit also
contain carbohydrates, carpasemine, benzyl
senevol and a glucoside. Papain is also used to
treat commercial beer, to degumm natural silk, as
a meat tenderizer and in the production of
chewing gums. Cosmetically it is used in
Shampoos and in a number of face-lifting
operations. In humans capaine slows down the
heart and thus reduces blood pressure.
5 Medicinal Value
a. Colon cancer
The fiber of papaya is able to bind cancer-causing
toxins in the colon and keep them away from the
healthy colon cells. These nutrients provide
synergistic protection for colon cells from free
radical damage to their DNA.
b. Anti-Inflammatory Effects
Protein enzymes including papain and
chymopapain and antioxidant nutrients found in
papaya; including vitamin C, vitamins E, and
beta-carotene, reduce the severity of the
conditions such as asthma, osteoarthritis, and
rheumatoid arthritis.
c. Rheumatoid Arthritis
Vitamin C-rich foods, such as papaya, provide
humans with protection against inflammatory
polyarthritis, a form of rheumatoid arthritis
involving two or more joints.
d. Promote Lung Health
If you are smoker, or if you are frequently
exposed to second hand smoke. Eating vitamin A
rich foods, such as papaya, help your lung healthy
and save your life.
e. Anti-Sickling Activity
Current research proves that papaya is having an
anti-sickling activity
f. Prevent Prostate Cancer
Men consuming lycopene-rich fruits and
vegetables such as papaya, tomatoes, apricots,
pink grapefruit, watermelon, and guava were 82%
less likely to have prostate cancer compared to
those consuming the least lycopene-rich foods.
G. Anticoagulant Effect
Injection of papian extract in a dog increases
prothrombin and coagulation threefold. It is also
claimed that the enzyme eliminates necrotic
tissues in chronic wounds, burns and ulcers.
Papain is also of commercial importance in the
brewery industry, in the food industry and in the
textile industry.
6. Allergies and Side Effects
Papaya is frequently used as a hair conditioner,
but should be used in small amounts. Papaya
releases a latex fluid when not quite ripe, which
can cause irritation and provoke allergic reaction
in some people.
The latex concentration of unripe papayas is
speculated to cause uterine contractions, which
may lead to a miscarriage. Papaya seed extracts
in large doses have a contraceptive effect on rats
and monkeys, but in small doses have no effect
on the unborn animals.
Excessive consumption of papaya can cause
carotenemia, the yellowing of soles and palms,
which is otherwise harmless. However, a very
large dose would need to be consumed; papaya
contains about 6% of the level of beta carotene
found in carrots (the most common cause of
a. Toxicity
Externally the papaya latex is an irritant to the
skin and internally it causes severe gastritis.
Some people are allergic to various parts of the
fruit and even the enzyme papain has its negative
b. Skin Discoloration
Eating too much of a yellow, green or orange-
colored food that contains beta carotene can
cause a benign form of skin discoloration called
carotenemia. The palms of the hands and soles of
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the feet are the most visible areas of the body
affected by carotenemia. Cutting back on your
papaya consumption will resolve the
discoloration of the skin.
c. Free Radical Scavenging Acivity
Papaya has many phenolic groups which may
scavange free radicals. Aqueous extract of papaya
leaves shows anti-oxidant activity
d. Respiratory Distress
Papain is also a potential allergen, according to
Purdue University, people who eat too much
papaya and ingest high levels of papain may
develop symptoms consistent with hay fever or
asthma, including wheezing, breathing difficulties
and nasal congestion.
e. Gastrointestinal Symptoms
Ironically, the same papain that calms your
stomach can cause an upset stomach when taken
in large amounts. The high fiber content of
papaya can also contribute to unrest of the
digestive system. The latex of the fruit's skin can
also cause irritation of the stomach.
7. Preliminary Research
Papaya seed extract may have in toxicity-induced
kidney failure. Evidently a kidney-transplant
patient in London was cured of a post-operative
infection by placing strips of papaya on the
wound for 48 hours. Women in India,
Bangladesh, Pakistan, Sri Lanka, and other
countries have long used green papaya as an
herbal medicine for contraception and abortion.
Enslaved women in the West Indies were noted
for consuming papaya to prevent pregnancies and
thus preventing their children from being born
into slavery.
Is Papaya in Pregnancy Safe or Not?
There are so many old wives tales and
information flooding the media that people
should or should not have certain foods to eat
during pregnancy. But there is one specific food
which I get asked about so regularly that I need to
write about it. That's Papaya, is it Safe?
There have been many research projects into the
effects of foods on pregnant women and papaya
is no exception. Now the problem with Papaya is
that in an unripe state the Papaya contains high
concentrations of Latex, this latex concentration
reduces upon ripening and once completely ripe
has almost no latex left.
The Papaya latex's main constituents are papain
and chymopapain which have teratogenic
(abnormalities of physiological development) and
abortifacient (Can induce an abortion) effects. It
does this by increasing the chances of uterine
contractions as the papain acts like prostaglandin
and oxytocin which are known to put a mother’s
body into labour and hence an adverse effect on
the babies and mothers health.
The Latex can also cause marked oedema and
haemorrhagic placentas which are bleeding and
hemorrhaging from the edge of the placenta, this
can result in severe complications in pregnancy
and normally an early delivery.
Table 3: Home remedies practices
Application of
peel with a
little milk and
protects soothe and moisturize the skin
Apply peel as
the face mask
for about 20
quite effective in ridding the skin of
Slice papaya
into small
pieces; soak in
vinegar for
several weeks.
Remove the
peel and
fights dandruff
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Vol. 1 No. 1 2013 Page | 13
vinegar with
lemon juice
can be applied
to the scalp
for 20 minutes
prior to
to fight
peel simmered
in olive oil,
almond oil
and rosehip
oil, and the
papaya oil
massaged into
the skin and
use with
honey and
rose water
Works as a skin toner and skin cleanser
papaya oil and
vinegar to
bath water,
with oils like
orange and
nourishing, refreshing and relaxing, and
can work as a pain reliever and muscle
Eat Fresh
Ripe papaya
in the morning
Indigestion, constipation, flatulence,
improve appetite
Apply unripe
papaya juice
on affected
pimples, eczema, mouth ulcer
Eat at least
200gm of ripe
Eliminate acid reflux.
It is used to treat mouth ulcer, gum
disease and toothache.
Unripe fruit
Contraceptive in some Asian countries
Soup made
from fish and
nearly ripen
In Southern China, lactating mothers
drink the soup to improve milk flow
Wash the leaf
and cut into
smaller pieces
Squeeze the
pulp and filter
with the cloth
serving per
It has a very
bitter taste.
Hence it may
provide some
relief to
dengue fever.
Can cure dengue fever.
Dressing wounds and injuries
A decoction
formed by
boiling the
outer part of
the roots
Cure of dyspepsia.
Dried seeds
pounded and
mixed with
skin irritant to lower fever
Fresh or dry
crushed seeds
bacteriostatic, bactericidal and fungicidal.
Take half
Expel intestinal worms
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Vol. 1 No. 1 2013 Page | 14
papaya seed
with warm
water in the
follow 2 hours
later with
50ml castor
oil and 350ml
milk on an
stomach, take
this for 2-4
Detoxify the liver
8. Cosmetic Benefits of Papaya
Rubbing the white pulp of raw papaya improves
pimples as well as wrinkles. Papaya works as a
good bleaching agent. It is an important
ingredient in bath soaps, astringents, detergent
bars and hand washes.Home Recipe for Papaya
Skin Lightner Experts suggest that papaya can
help in removing dead worn-out skin cells and
replace it with healthy new cells, thereby
lightening the color of our skin. For this, one can
prepare a paste of raw papaya and apply it on the
skin once for few days.
9. Conclusion:
Carica papaya is a neutraceutical plant having a
wide range of pharmacological activates. The
whole plant has its own medicinal value. The
wide range of enzymes, vitamins present in
Carica papaya makes it a neutraceutical plant.
The present review is about all the prominent
pharmacological activity, home remedies and side
effects of Carica papaya.
10. Reference:
1.Dawson, emma (1997). The Medicinal Properties of
the Papaya, Carica papaya L. [online]. at: HYPERLINK
2.J Dairy Sci. 2010 Nov;93(11):5059-68. Processing
optimization of probiotic yogurt containing papain
using response surface methodology. HYPERLINK
PMID: 20965320
3.University of Maryland Medical Center.
5.Antifungal effects of pawpaw seed extracts and papain
on post harvest Carica papaya L. fruit rot. Nwinyi,
Obinna and Abikoye, B. A. (2010)
6. Antifungal effects of pawpaw seed extracts and
papain on post harvest Carica papaya L. fruit rot.
African Journal of Agricultural Research, 5 (12). pp.
wuemeka%2520and%2520Anthonia.pdf" ISSN 1991-
637X (PDF)
9.Desser L,et al. Oral therapy with proteolytic enzyes
decreases excessive TGF-beta levels in human blood.
Cancer Chemother Pharmacol 2001;47:S10-5.
PMID: 11561866
10.Desser L, Zavadova E, Herbacek I. Oral enzymes as
additive cancer therapy. Int J Immunotherapy.
4" ISSN 0255-9625
12.Lohiya NK, Goyal RB, Jayaprakash D, Ansari AS,
Sharma S. Antifertility effects of aqueous extract of
Carica papaya seeds in male rats. Planta Med.
13. Chinoy NJ, D’Souza JM, Padman P. Effects of crude
extract of Carica papaya seeds in male albino mice.
Reprod Toxicol. 1994;8:75–9.
14. Adebiyi A, Ganesan AP, Prasad RN. Tocolytic and
toxic activity of papaya seed extract on isolated rat
uterus. Life Sci. 2003;74:581–92.
15. Udoh P, Essien I, Udoh F. Effect of Carica papaya
(paw paw) seeds extract on the morphology of
pituitary-gonadal axis of male Wistar rats. Phytother
Res. 2005;19:1065–8.
16.Milind, parle (2011). Basketfull benefits of pappaya.
International reasearch journal of pharmacy, 6-12.
18.AKHTAR (2000). anthelminitic activity of medicanal
plants with particular reference to there use in animals
in Indo-Pakistan subcontinent. Elesvier, 38, 99-107.
19.AYOOLA (2010). A phytochemical and nutrient
evaluation of carcia Papaya leaes. IJRRAS, 5 (3),.
20.BV, owoyele (2008). anti-inflamatory activities of
ethanolic extract of carica pappaya leaves.
onflammopharmacology, 16, 168-173.
21.Chavez, padro (2011 jan). Antifungal activity in
ehanolic extracts of carica pappaya L cv Maradol leaves
and seeds. NCBI, 1 (51), 54-60.
Journal of Medicinal Plants Studies
Vol. 1 No. 1 2013 Page | 15
22. Marston A, Hostettmann K. Separation and
quantification of flavonoids. In: Andersen OM, Markham
KR, editors. Flavonoids: chemistry, biochemistry,
applications. Boca Raton: CRC Press/Taylor Francis;
2006. pp. 1–36.
23. Oloyede OI. Chemical profile of unripe pulp of Carica
papaya L. Pak J Nutr. 2005;4:379–381. doi:
24. Marfo EK, Oke OL, Afolabi OA. Chemical composition
of papaya (Carica papaya) seeds. Food Chem.
1986;22:259–266. doi: 10.1016/0308-8146(86)90084-
25. Ordoñez VP, Vega EM, Malagón AO. Phytochemical
study of native plant species used in traditional
medicine in Loja province. Lyonia. 2006;10:65–71.
26. Oliva A, Meepagala K, Wedge D, Harries D, Hale A,
Aliotta G, Duke S. Natural fungicides from Ruta
graveolens L. leaves, including a new quinolone alkaloid.
J Agric Food Chem. 2003;51:890–896. doi:
27. Aqil F, Ahmad I. Broad-spectrum antibacterial and
antifungal properties of certain traditionally used
Indian medicinal plants. World J Microbiol Biotechnol.
2003;19:653–657. doi: 10.1023/A:1025128104056.
28. Chen Y-T, Hsu L-H, Huang I-P, Tsai T-C, Lee G-C,
Shaw J-F. Gene cloning and characterization of a novel
recombinant antifungal chitinase from papaya (Carica
papaya) J Agric Food Chem. 2007;55:714–722. doi:
... The papaya (Carica papaya L.), is a tree from the Caricaceae family, also, is one of the greatest significant fruits grown during the world's steamy and subtropical districts [1][2][3][4]. The Caricaceae family is made up of six types of fruticose, herbaceous, or arboreal dicotyledonous florae that share a mutual phylogenetic basis [5,6]. ...
... Similar reactions have been recorded by Refs. [2,42,43]. The midrib lengthens and the leaf lobes become more deeply lobed as the leaf matures; folds form, and new minor ribs form around the fifth midrib. ...
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Papaya is high in nutrients, delicious flavours, and potent antioxidants like lycopene; all of these bio constituents may reduce the risk of a variety of ailments, particularly those associated with age-ing, such as heart disease and cancer. The papaya (Carica papaya L.) despite having a lengthy farming history and important germplasm, little is known about its genetic basis and variety. In response to environmental changes, the results of papaya strain diversity show variation in yield, vegetative traits, morphological characteristics of flowers, fruits, and leaves. To characterise the genetic assessment, morphological, agronomical traits, and an inter-simple sequence repeat (ISSR) molecular marker were studied across 9 papaya strains. For the past three decades, DNA Molecular markers have been used. The DNA contours provide data on the strains, display the entire genome, and showing difference in both the encrypting and non-encrypting regions, as well as polymorphism. A mix of morphologic, chemical, and molecular characteristics of papaya strains can be used to well measure the degree of variety and correlation among papaya strains. The primers UBC812 and UBC825 performed the best for identifying and estimating the diversity of papaya accessions, followed by UBC864, UBC809, UBC811 and HB-13. The 9 papaya strains were classified into two clusters using UPGMA cluster analysis and a similarity coefficient obtained from ISSR markers. Among the nine papaya strains, the pair S3 and S7 had the highest similarity (0.97). The morphological characteristics are similar to molecular analysis. This work provided a quick and steadfast method for estimating variability among different Papaya strains, which breeders could use to improve papaya.
... These cancers often grow faster than receptor-positive breast cancers. In most cases pre-menopausal women develop hormone receptor-negative cancers and appears to be common in younger women and in women with African-American or Hispanic/Latina ancestry [46] . Some of the ERbreast cancers are Her-2 positive that cancer are now effectively targeted with Herceptin, which is an antibody for Her-2 proteins [47] . ...
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Aim: Breast cancer is typically detected either during a screening examination or after a woman notices a lump. Breast cancers have different phenotypes depending on the presence/absence of an estrogen receptor (ER) and/or an epidermal growth factor (Her-2) receptor. The objective of the present investigation was to investigate growth inhibitory activity of methanol-, ethanol-, and water-extracts from papaya fruit and leaves on MDA-MB-231 (ER⁻/Her-2⁻), MCF-7 (ER⁺/Her-2⁻), SK-BR- 3 (ER⁻/Her-2⁺) and MDA-MB-361, AU565 (ER⁺/Her-2⁺) breast cancer cells. Methods: The anti-oxidation potential of papaya extracts was determined by assessing their total polyphenol content, total flavonoid content and by assaying their anti-oxidation capacity. The effects on breast cancer cells proliferation were determined using a WST-1 assay. Results: The seeds and leaves contained higher anti-oxidation potential than that of the skin and pulp fractions. Our data indicate that methanol- and ethanol-extracts of papaya leaves, skin, pulp, and seeds have no effect on any of the breast cancer cell lines, whereas water-extract of leaves and seeds caused low to modest cytotoxic effects only on ER-negative breast cancer cell lines. Conclusion: Our data suggest that bioactive compound in papaya leaves can be potentially used to develop anti-cancer agents for ER-negative breast cancer.
... Wall (2006) documented the application of C. papaya in treating several conditions, such as stomach disorders, diarrhea, skin diseases, male contraceptives, and home remedies for the common cold (Wall 2006). The extracts from C. papaya leaves, fruits, and seeds were shown to possess anti-cancer activities in colorectal, prostate, cervical, and breast cancers (Aravind et al. 2013;Lohsoonthorn and Danvivat 1995;Shahar et al. 2011;Pandey et al. 2017;Siegel et al. 2010). Moreover, few studies reported the significance of C. papaya leaves juice in increasing the platelet count among patients suffering from Dengue fever (Ahmad et al. 2011;Rajapakse et al. 2019). ...
... Wall (2006) documented the application of C. papaya in treating several conditions, such as stomach disorders, diarrhea, skin diseases, male contraceptives, and home remedies for the common cold (Wall 2006). The extracts from C. papaya leaves, fruits, and seeds were shown to possess anti-cancer activities in colorectal, prostate, cervical, and breast cancers (Aravind et al. 2013;Lohsoonthorn and Danvivat 1995;Shahar et al. 2011;Pandey et al. 2017;Siegel et al. 2010). Moreover, few studies reported the significance of C. papaya leaves juice in increasing the platelet count among patients suffering from Dengue fever (Ahmad et al. 2011;Rajapakse et al. 2019). ...
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Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host cells to regulate certain host cellular functions. How nutrient-rich plants regulate host cellular functions, which in turn alleviate physiological and disease conditions in the host remains to be explored in detail. This computational study explores the potential targets, putative role, and functional implications of miRNAs derived from Carica papaya L., one of the most cultivated tropical crops in the world and a rich source of phytochemicals and enzymes, in human diet. Using the next-generation sequencing, -Illumina HiSeq2500, ~ 30 million small RNA sequence reads were generated from C. papaya young leaves, resulting in the identification of a total of 1798 known and 49 novel miRNAs. Selected novel C. papaya miRNAs were predicted to regulate certain human targets, and subsequent annotation of gene functions indicated a probable role in various biological processes and pathways, such as MAPK, WNT, and GPCR signaling pathways, and platelet activation. These presumptive target gene in humans were predominantly linked to various diseases, including cancer, diabetes, mental illness, and platelet disorder. The computational finding of this study provides insights into how C. papaya-derived miRNAs may regulate certain conditions of human disease and provide a new perspective on human health. However, the therapeutic potential of C. papaya miRNA can be further explored through experimental studies.
... Furthermore, the plant species exhibit a combination of alkaline with potassium carbonate or borax; which produces potential results in treatment of cutaneous tubercles warts, eczema, sinuses corns and other skin hardness and also administered into tumors of indolent glandular to enhance their absorption. Papaya green fruits are useful in treatment of hypertension, constipation, dyspepsia, general debility, amenorrhea, stimulate reproductive organs and expelling of worms (Aravind et al., 2013). ...
... Papain and chymopapain are examples of such active compounds present in papaya that may help to cure cancer, diabetes, and heart diseases. Ripe fruit of papaya is consumed fresh or can be processed in the production of jam, jelly, marmalade, candies and vegetable if unripe [3]. Southern Mexico and Costa Rica are the origin of papaya and it is native to central and southern American states. ...
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Viral diseases have been studied in-depth for reducing quality, yield, health and longevity of the fruit, to highlight the economic losses. Positive-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit trees. One of the best examples is papaya ringspot virus (PRSV). It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae, Cucurbitaceae and Caricaceae. This virus has a serious threat to the production of papaya, which is famous for its high nutritional and pharmaceutical values. The plant parts such as leaves, latex, seeds, fruits, bark, peel and roots may contain the biological compound that can be isolated and used in pharmaceutical industries as a disease control. Viral disease symptoms consist of vein clearing and yellowing of young leaves. Distinctive ring spot patterns with concentric rings and spots on fruit reduce its quality and taste. The virus has two major strains P and W. The former cause disease in papaya and cucurbits while the later one in papaya. Virion comprises 94.4% protein, including a 36 kDa coat protein which is a component responsible for a non-persistent transmission through aphids, and 5.5% nucleic acid. Cross protection, development of transgenic crops, exploring the resistant sources and induction of pathogen derived resistance have been recorded as effective management of PRSV. Along with these practices reduced aphid population through insecticides and plant extracts have been found ecofriendly approaches to minimize the disease incidence. Adoption of transgenic crops is a big challenge for the success of disease resistant papaya crops. The aim of this review is to understand the genomic nature of PRSV, detection methods and the different advanced control methods. This review article will be helpful in developing the best management strategies for controlling PRSV.
is a tropical fruit that is widely produced and obsessively consumed, both for its delicious flavor and for its numerous medicinal benefits. is a tropical fruit that ranges in colour from orange red to yellow orange. The entire plant was used as medicine, including the fruit, leaves, roots, peel, bark, seed, and pulp. Papaya is the common name for this plant, and Papita is the Hindi name for it. It is now cultivated all over the world and used as an attractive tree in gardens. It was first introduced to India in the 17th century. Due to the presence of phenolics, flavonoid, and alkaloids as the active ingredients, papaya is recognised for its antioxidant, antibacterial, anticancer, antifertility, antiinflammatory, antiulcer, antidiabetic, and hepatoprotective properties, among others. phytochemicals that are important Many commercial goods made from diverse plant components are available on the market and are used for a variety of applications. This review discusses the fruit's origins and briefly examines its nutritional and pharmacological properties.
Green synthesis of zinc oxide nanomaterial has received very significant importance in many fields. The aim of this research is to develop a novel green synthetic route to synthesize nanoparticles. The present study deals with green synthesis of zinc oxide nanoparticles using aqueous extracts of Carica papaya leaves. The aqueous extracts of Carica papaya leaves plays a major role in reducing the zinc acetate to zinc oxide nanoparticles and acts as surface stabilizing substance for zinc oxide nanoparticles production. Here, the characterization of green synthesized Carica papaya ZnO nanoparticles was done using various techniques like transmission electron microscope analysis (TEM), X-ray diffraction analysis (XRD) and Energy dispersive X-ray (EDX) analysis.
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This study investigated antibacterial activities, chemical composition and extract efficacy of Carica papaya peel (CPPE) var. Sekaki/ Hong Kong. Nine green solvents were used to extract the Carica papaya peel, and the extracts were subjected to antibacterial tests and assays against 14 bacteria. The most potent extract was then subjected to phenolic and flavonoid assays, gas chromatography-mass spectrometry (GC/MS) analysis, and efficacy study on food model systems. All CPPEs showed antibacterial activities, and pentane extract had moderate to clear inhibitions against all 14 bacteria. Ethanol extract of Carica papaya peel (ECPPE) inhibited C. perfringens, L. monocytogenes, B. subtilis, V. parahaemolyticus , and V. vulnificus with a minimum inhibitory concentration (MIC) of 1.563 mg/ml; therefore, the ECPPE was selected as the most potent extract. The total phenolic (TPC) and flavonoid contents (TFC) of the CPPEs ranged between 6.20 to 58.75 mg GAE/g DW and 1.35–29.09 mg QE/g DW, respectively. Palmitic acid, linoleic acid, β-sitosterol and stigmasterol in ECPPE may be potential antibacterial compounds that render antibacterial activities. The ECPPE could effectively inhibit the tested bacteria in low carbohydrate and high protein, fat, and fibre food model systems, which may suit the investigation of ECPPE efficacy in meat, poultry and dairy products, high fat-content products such as mayonnaise, butter and margarine and high fibre food such as legumes, lettuce and barley.
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Papaya (Carica papaya L.) belongs to the family Caricaceae comprising 31 species in four genera is a tropical plant. It is rich in nutrients like Vit A, C, B1 etc.which give protection against heart diseases and colon cancer. The chemical constituents are present in different parts of papaya plant and have varied useful medicinal and pharmaceutical uses like antimicrobial property, anthelmintic property, antioxidant activities, wound healing activity, anti – cancer activity, anti-hypertensive activity, antifungal activity etc. It is rich source of papain enzyme which is effective against cancer and has several industrial uses as well. Along with the enormous advantages and uses, there are toxic and side effects of papaya also like the pollen of papaya causes allergy to the people and it has abortifacient properties as well. Therefore, there is a need to extract these bioactive compounds to utilize them for the welfare of the humans and intake of papaya as fruit salads, fruit juice, leaf extract, decoction prepared through papaya leaves, etc. should be a part of our diet.
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Unlabelled: Therapy with oral proteolytic enzymes (OET) with combination drug products containing papain, bromelain, trypsin, and chymotrypsin has been shown to be beneficial in clinical settings such as radiotherapy-induced fibrosis, bleomycin pneumotoxicity and immunosuppression in cancer, all of which are nowadays known to be accompanied by excessive transforming growth factor-beta (TGF-beta) production. It has been demonstrated that proteolytic enzymes reduce TGF-beta levels in serum by converting the protease inhibitor alpha2 macroglobulin (alpha2M) from the "slow" form into the "fast" form, whereby the "fast" form binds and inactivates TGF-beta irreversibly. In this study we have investigated the effect of OET on the concentration of TGF-beta1 in serum of patients with rheumatoid arthritis (RA) (n = 38), osteomyelofibrosis (OMF) (n = 7) and herpes zoster (HZ) (n = 7). Seventy-eight healthy volunteers served as controls. TGF-beta1 levels in serum were assessed by enzyme-linked immunosorbent assay (ELISA). We have demonstrated that in healthy volunteers and in patients there exists a correlation between active and latent TGF-beta1 in serum (r=0.8021; P<0.0001). Treatment with OET had no significant effect on TGF-beta1 concentration in healthy volunteers or patients with a normal level of TGF-beta1. In patients with elevated TGF-beta1 concentration (> 50 ng/ml serum), OET reduced TGF-beta1 in RA (P < 0.005), in OMF (P < 0.05) and in HZ (P < 0.05). Conclusion: These results support the concept that OET is beneficial in diseases characterized in part by TGF-beta1 overproduction.
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Ethanolic extracts of 22 traditionally used Indian medicinal plants were studied for their antimicrobial activity against seven bacteria (Staphylococcus aureus, Salmonella typhimurium, S. paratyphi, S. typhi, E. coli, Shigella dysenteriae and Pseudomonas aeruginosa) and five filamentous fungi (Aspergillus niger, Alternaria alternata, Fusarium chlamydosporum, Rhizoctonia bataticola and Trichoderma viride) and a yeast Candida albicans of clinical origin. Of these, 16 plant extracts showed varied level of antibacterial activity against one or more test bacteria. Similarly antifungal and anticandidal activity was detected among 17 and 9 plant extracts respectively. Broad-spectrum antimicrobial activity (both antibacterial and antifungal) was detected among crude extracts of Bryophyllum pinnatum (leaves), Caesalpinia bonducella (seeds), Delonix regia (flower), Hedychium spicatum (fruits), Mangifera indica (leaves), Murraya coenigii (leaves) and Syzgium cumini (seeds). Similarly extracts of Cichorium intybus (roots), Ficus religiosa (leaves) and Trigonella foenum-graecum (leaves) demonstrated more antibacterial activity with less antifungal activity. On the other hand Pistacia integerrima (stems) and Rheum emodi (roots) demonstrated more antifungal activity with less antibacterial activity.
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Bioactive compounds from vegetal sources are a potential source of natural antifungic. An ethanol extraction was used to obtain bioactive compounds from Carica papaya L. cv. Maradol leaves and seeds of discarded ripe and unripe fruit. Both, extraction time and the papaya tissue flour:organic solvent ratio significantly affected yield, with the longest time and highest flour:solvent ratio producing the highest yield. The effect of time on extraction efficiency was confirmed by qualitative identification of the compounds present in the lowest and highest yield extracts. Analysis of the leaf extract with phytochemical tests showed the presence of alkaloids, flavonoids and terpenes. Antifungal effectiveness was determined by challenging the extracts (LE, SRE, SUE) from the best extraction treatment against three phytopathogenic fungi: Rhizopus stolonifer, Fusarium spp. and Colletotrichum gloeosporioides. The leaf extract exhibited the broadest action spectrum. The MIC(50) for the leaf extract was 0.625 mg ml(-1) for Fusarium spp. and >10 mg ml(-1) for C. gloeosporioides, both equal to approximately 20% mycelial growth inhibition. Ethanolic extracts from Carica papaya L. cv. Maradol leaves are a potential source of secondary metabolites with antifungal properties.
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Exposure to oxygen may induce a lack of functionality of probiotic dairy foods because the anaerobic metabolism of probiotic bacteria compromises during storage the maintenance of their viability to provide benefits to consumer health. Glucose oxidase can constitute a potential alternative to increase the survival of probiotic bacteria in yogurt because it consumes the oxygen permeating to the inside of the pot during storage, thus making it possible to avoid the use of chemical additives. This research aimed to optimize the processing of probiotic yogurt supplemented with glucose oxidase using response surface methodology and to determine the levels of glucose and glucose oxidase that minimize the concentration of dissolved oxygen and maximize the Bifidobacterium longum count by the desirability function. Response surface methodology mathematical models adequately described the process, with adjusted determination coefficients of 83% for the oxygen and 94% for the B. longum. Linear and quadratic effects of the glucose oxidase were reported for the oxygen model, whereas for the B. longum count model an influence of the glucose oxidase at the linear level was observed followed by the quadratic influence of glucose and quadratic effect of glucose oxidase. The desirability function indicated that 62.32 ppm of glucose oxidase and 4.35 ppm of glucose was the best combination of these components for optimization of probiotic yogurt processing. An additional validation experiment was performed and results showed acceptable error between the predicted and experimental results.
Oral therapy with proteolytic enzymes (OTPE) (papain, bromelain, trypsin, chymotrypsin amylase and lipase) has been used in additive cancer therapy for several years and has led to a reduction in adverse effects after cancer treatment (radiation and chemotherapy). OTPE has been proven to have a beneficial effect, especially in cancers and other conditions involving elevated transforming growth factor-β (TGF-β) expression. Proteases such as trypsin, chymotrypsin, bromelain and papain have been demonstrated to be capable of converting the slow form of α2-macroglobulin into the fast form. This form of α2-macroglobulin is capable of irreversibly binding TGF-β. Subsequently the TGF-β-α2-macroglobulin complex can be quickly removed via endocytosis. Since the production of TGF-β is regulated by an autocrine loop, removal of TGF-β results in down-regulation of TGF-β overproduction. It has been proposed that OTPE may act through this interruption of the autocrine loop. In vitro reduction in TGF-β overexpression in tumor-associated macrophages leads to enhanced tumor killing capacity as well as to stimulation of natural killer cell and granulocyte cytotoxicity. In clinical trials with patients suffering from polycythemia vera or myelofibrosis, treatment with proteolytic enzymes has been shown to reduce elevated serum concentrations of TGF-β. These findings suggest that through reduction of TGF-β overproduction, OTPE could be beneficial in the inhibition of fibrosis and in additive tumor therapy.
Helminthiasis is one of the most important group of parasitic diseases in Indo-Pakistan subcontinent resulting in heavy production losses in livestock. A wide variety of anthelmintics is used for the treatment of helminths in animals. However, the development of resistance in helminths against commonly used anthelmintics have always been a challenge faced by the animal health care professionals. Therefore, exploitation of anthelmintic potential of plants indigenous to Indo-Pak subcontinent is an area of research interest. This paper reviews the use of some indigenous plants as anthelmintics in animals. # 2000 Elsevier Science B.V. All rights reserved.
Unripe pulp of Carica papaya was screened to test for the presence of certain phytochemicals. Chemical composition of the pulp were determined. Phytochemical screening of mature unripe pulp of Carica papaya (dry weight) showed the presence of saponins and cardenolides while chemical analysis revealed the presence of potassium (223.0mg/100g) as well as sodium, calcium, iron, phosphorus, zinc, copper, magnesium and manganese in considerable quantities. Proximate analysis of the pulp showed that it contained starch (43.28%), sugars (15.15%), crude protein (13.63%), crude fat (1.29%), moisture (10.65%) and fibre (1.88%). All these results indicate that the pulp of mature unripe Carica papaya contains nutrients and mineral elements that may be useful in nutrition. The presence of some phytochemicals like saponins and cardenolides explained the astringent action of the plant encountered in the numerous therapeutic uses.