Traditional and medicinal uses of Carica papaya

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Journal of Medicinal Plants Studies
Year : 2013, Volume : 1, Issue : 1
First page : (7) Last page : (15)
ISSN: 2320-3862
Online Available at www.plantsjournal.com
Journal of Medicinal Plants Studies
Vol. 1 No. 1 2013 www.plantsjournal.com Page | 7
Traditional and Medicinal Uses of Carica papaya
Aravind. G *1, Debjit Bhowmik 1 , Duraivel. S 1, Harish. G 1
1. Department of Pharmacognosy, Nimra College of Pharmacy, Vijayawada, Andhra Pradesh,
India (E-mail: Voltas170@gmail.com)
Papaya, botanical name
Carica papaya
, is an lozenge tropical fruit, often seen in orange
-
red, yellow
-
green and
yellow-orange hues, with a rich orange pulp. The fruit is not just delicious and healthy, but whole plant parts, fruit,
roots, bark, peel, seeds and pulp are also known to have medicinal properties. The many benefits of papaya owed
due to high content of Vitamins A, B and C, proteolytic enzymes like papain and chymopapain which have antiviral,
antifungal and antibacterial properties. Carica papaya can be used for treatment of a numerous diseases like warts,
corns, sinuses, eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation,
amenorrhoea, general debility, expel worms and stimulate reproductive organs and many, as a result Carica papaya
can be regarded as a Neutraceutical. The present article reviews the pharmacological uses of Carica papaya and
side/toxic effects. Carica papaya contains an enzyme known as papain which is present in the bark, leaves and fruit.
The milky juice is extracted, dried and used as a chewing gum for digestive problems, toothpaste and meat
tenderizers. It also contains many biological active compounds including chymopapain and papain which is the
ingredient that aids digestive system, and again used in treatment of arthritis.
Keyword: Carica Papaya, Papain, Chymopapain, Neutraceutical
1. Introduction:
Papaya is a powerhouse of nutrients and is
available throughout the year. It is a rich source
of threes powerful antioxidant vitamin C, vitamin
A and vitamin E; the minerals, magnesium and
potassium; the B vitamin pantothenic acid and
folate and fiber. In addition to all this, it contains
a digestive enzyme-papaintha effectively treats
causes of trauma, allergies and sports injuries. All
the nutrients of papaya as a whole improve
cardiovascular system, protect against heart
diseases, heart attacks, strokes and prevent colon
cancer. The fruit is an excellent source of beta
carotene that prevents damage caused by free
radicals that may cause some forms of cancer. It
is reported that it helps in the prevention of
diabetic heart disease. Papaya lowers high
cholesterol levels as it is a good source of fiber.
Papaya effectively treats and improves all types
of digestive and abdominal disorders. It is a
medicine for dyspepsia, hyperacidity, dysentery
and constipation. Papaya helps in the digestion of
proteins as it is a rich source of proteolytic
enzymes. Even papain-a digestive enzyme found
in papaya is extracted, dried as a powder and used
as an aid in digestion. Ripe fruit consumed
regularly helps in habitual constipation. It is also
reported that papaya prevents premature aging. It
may be that it works because a poor digestion
does not provide enough nutrients to our body.
The fruit is regarded as a remedy for abdominal
disorders, The skin of papaya works as a best

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medicine for wounds. Even you can use the pulp
left after extracting the juice from papaya as
poultice on the wounds. The enzymes papain and
chymopapain and antioxidant nutrients found in
papaya have been found helpful in lowering
inflammation and healing burns. That is why
people with diseases( such as asthma, rheumatoid
arthritis, and osteoarthritis) that are worsened by
inflammation, find relief as the severity of the
condition reduces after taking all these nutrients.
Papaya contributes to a healthy immune system
by increasing your resistance to coughs and colds
because of its vitamin A and C contents. Papaya
included in your diet ensures a good supply of
vitamin A and C that are highly essential for
maintaining a good health. Carica papaya
constituents exhibit alkaline combination, as with
borax or potassium carbonate and they have
showed good results in treatment of warts, corns,
sinuses, eczema, cutaneous tubercles and other
hardness of the skin, and also injected into
indolent glandular tumors to promote their
absorption. Green fruits of papaya are used to
treat high blood pressure, dyspepsia, constipation,
amenorrhoea, general debility, expel worms and
stimulate reproductive organs.
2. Biological Sources
Botanical Name: Carica papaya
Family Name: Caricaceae
Common Name: Papaya, Paw Paw, Kates, Papaw
Part Used: Leaves, Fruits, bark, leaves
3. Nutritional Value
The papaya, papaw, or pawpaw is the fruit of the
plant Carica papaya, the only species in the genus
Carica of the plant family Caricaceae. It is native
to the tropics of the Americas. The papaya is a
large, tree-like plant, with a single stem growing
from 5 to 10 m (16 to 33 ft) tall, with spirally
arranged leaves confined to the top of the trunk.
The leaves are large, 50–70 cm in diameter,
deeply palmately lobed, with seven lobes. The
tree is usually unbranched, unless lopped. The
flowers appear on the axils of the leaves,
maturing into large fruit. The fruit is ripe when it
feels soft and its skin has attained amber to
orange hue.
These nutritional values of papaya help to prevent
the oxidation of cholesterol. Papaya is rich in iron
and calcium; a good source of vitamins A, B and
G and an excellent source of vitamin C (ascorbic
acid). The extracts of unripe C. papaya contain
terpenoids, alkaloids, flavonoids, carbohydrates,
glycosides, saponins, and steroids.
Table 1: Papaya, raw Nutritional value per 100 g
Energy
163KJ
Sodium
3 mg
Potassium
257
Phosphorus
5
Magnesium
10
Iron
0.10
Calcium
24
Vitamin C
61.8
Folate (vit. B
9)
38
Vitamin B
6
0.1
Niacin (vit. B
3
)
0.338
Riboflavin (vit.
B
2
)
0.05
Thiamine (vit.
B
1
) 0.04 mg
0.04
Vitamin A
328
Protein
0.61
Fat
0.14
Dietary fibre
1.8
Sugars
5.9
Carbohydrates
9.81
Table 2: Carica papaya is a pack of enzymes
Phytoconstituents
Carica papaya part
Enzyme
Papain,chymopapain
Unripe fruit
Carotenoids
Β carotene,crytoxanthin
Fruits
Carposide
Roots
Glucosinolates
Benzyl isothiocynate, papaya oil
Seeds
Minerals
Ca, K, Mg,Zn,Mn,Fe
Shoots, leaves
Monoterpenoids
Linalool,4-terpinol
Fruits
Flavoniods
Myricetin,kaemferol
Shoots
Alkaloids
Carpinine,carpaine,vitamin C and E
Leaves
These nutritional values of papaya help to prevent
the oxidation of cholesterol. Papaya is rich in iron
and calcium; a good source of vitamins A, B and

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G and an excellent source of vitamin C (ascorbic
acid). The extracts of unripe C. papaya contain
terpenoids, alkaloids, flavonoids, carbohydrates,
glycosides, saponins, and steroids.
a. Proteolytic Enzymes
Papaya contains several unique protein-digesting
proteolytic enzymes including papain and
chymopapain.
b. Papain
This enzyme is similar to pepsin, a digestive
enzyme in our body.
c. Chymopapain
A drug made from chymopapain used to be very
popular in treating slipped disk.
Both papain and chymopapain can help lower
inflammation and improve healing from burns.
d. Carpaine
The alkaloid, Carpaine, slows the heart rate in
humans and thus reduces blood pressure. Its
action is similar to the drug prescribed for heart
patients, digitalis. The alkaloid is reported to be
able to kill worms and amoebas.
e. Lycopene
Papaya has an abundance of cancer fighting
lycopene. It is a key intermediate in the
biosynthesis of many important carotenoids, such
as beta-carotene and xanthophylls.
f. Fibrin
Another useful compound not readily found in
the plant kingdom is Fibrin. It reduces the risk of
blood clots and improves the quality of blood
cells, optimizing the ability of blood to flow
through the circulatory system. Fibrin is also
important in preventing stoke.
4. Pharmacological Activity of Each Division
of Carica Papaya
Whole Carica papaya has a unique
pharmacological uses
4.1 Leaves
Papaya leaf has a numberless of benefits. In some
parts of Asia, the young leaves of the papaya are
steamed and eaten like spinach.
a. Dengue fever
Commencing on studies of Dr. Sanath Hettige,
who conducted the research on 70 dengue fever
patients, said papaya leaf juice helps increase
white blood cells and platelets, normalizes
clotting, and repairs the liver.
b. Cancer Cell Growth Inhibition
Recent research on papaya leaf tea extract has
demonstrated cancer cell growth inhibition. It
appears to boost the production of key signaling
molecules called Th1-type cytokines, which help
regulate the immune system.
c. Antimalarial and Antiplasmodial Activity
Papaya leaves are made into tea as a treatment for
malaria.[15] Antimalarial and antiplasmodial
activity has been noted in some preparations of
the plant,[15] but the mechanism is not understood
and not scientifically proven
d. Facilitate Digestion
The leaves of the papaya plants contain
chemical compounds of karpain, Substance which
kills microorganisms that often interfere with the
digestive function.
Additional Benefits of Papaya Leaves
 As an acne medicine
 Increase appetite
 Ease menstrual pain
 Meat tenderizer
 Relieve nausea
4.2 Fruit
Papaya fruit is a rich source of nutrients such as
provitamin A carotenoids, vitamin C, B vitamins,
lycopene, dietary minerals and dietary fibre.
Danielone is a phytoalexin found in the papaya
fruit. This compound showed high antifungal
activity against Colletotrichum gloesporioides, a
pathogenic fungus of papaya

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a. Laxative
Ripe papaya fruit is laxative which assures of
regular bowel movement.
b. Indigestion
The milky juice which is tapped from the green,
mature fruit while still in the tree contains an
enzyme known as "papain". People use this in the
preparation of different remedies for indigestion.
c. Void the Heart Attack or Stroke
The folic acid found in papayas is needed for the
conversion of homocysteine into amino acids
such as cysteine or methionine. If unconverted,
homocysteine can directly damage blood vessel
walls, is considered a significant risk factor for a
heart attack or stroke.
4.3 Seeds
The black seeds of the papaya are edible and have
a sharp, spicy taste. They are sometimes ground
and used as a substitute for black pepper.
a. Nephro-Protective Activity
In wistar rats nephro-protective activity was
observed in dose related manner. Concentration
of urine and creatinine were evaluated.
b. More Potent
The papaya seeds are very pungent and peppery,
making them almost unpalatable. However the
seeds seem to have more potent medicinal values
than the flesh.
 Papaya seeds have antibacterial properties and are
effective against E.coli, Salmonella and
Staphylococcus infections.
 Papaya seeds may protect the kidneys from toxin-
induced kidney failure.
 Papaya seeds can eliminate intestinal parasites.
 Papaya seeds help detoxify the liver
 As a skin irritant to lower fever
 Cure for piles and typhoid
 anti-helminthic and anti-amoebic properties
Dried papaya seeds actually look quite similar to
peppercorns and can be used in just the same
way. Grinding a couple over a meal, especially
protein rich meals, is a simple way to add extra
enzymes to your diet and improve your digestive
health.
4.4 Peel
Papaya peel is often used in cosmetics. The
papaya peel can also be used in many home
remedies.
a. Sunscreen And Soothing Slave
The presence of vitamin A helps to restore and
rebuild damaged skin. Applied papaya peel used
as skin lightening agent. When peel mixed with
honey and applied it can act as soothe and
moisturizers the skin.
b. Fight Dandruff
The papaya vinegar with lemon juice can be
applied to the scalp for 20 minutes prior to
shampooing to fight dandruff.
c. Muscle Relaxant
Adding papaya oil and vinegar to bath water,
along with essential oils like lavender, orange and
rosemary can be nourishing, refreshing and
relaxing, and can work as a pain reliever and
muscle relaxant.
4.5 Roots
Juice from papaya roots is used in some countries
of Asia to ease urinary troubles. Papaya leaf
when dried and cured like a cigar, is smoked by
asthmatic persons. An infusion of fresh papaya
leaves is used by person to expel or destroy
intestinal worms. Fresh young papaya are also
used to remedy colic, a certain stomach disorder
or cramp.
A decoction formed by boiling the outer part of
the roots of the papaya tree in the cure of
dyspepsia.
4.6 Latex
Fig 1: Fruits of Papaya

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The milky sap of a unripe papaya contains Papain
and chymopapain. chymopapain was approved
for intradiscal injection in patients with
documented herniated lumbar intervertebra discs
and who had not responded to "conservative
therapy". Vitamins and traces of an alkaloid
called Carpaine have also been found in the latex.
Apart from natural oils, the seeds of the fruit also
contain carbohydrates, carpasemine, benzyl
senevol and a glucoside. Papain is also used to
treat commercial beer, to degumm natural silk, as
a meat tenderizer and in the production of
chewing gums. Cosmetically it is used in
Shampoos and in a number of face-lifting
operations. In humans capaine slows down the
heart and thus reduces blood pressure.
5 Medicinal Value
a. Colon cancer
The fiber of papaya is able to bind cancer-causing
toxins in the colon and keep them away from the
healthy colon cells. These nutrients provide
synergistic protection for colon cells from free
radical damage to their DNA.
b. Anti-Inflammatory Effects
Protein enzymes including papain and
chymopapain and antioxidant nutrients found in
papaya; including vitamin C, vitamins E, and
beta-carotene, reduce the severity of the
conditions such as asthma, osteoarthritis, and
rheumatoid arthritis.
c. Rheumatoid Arthritis
Vitamin C-rich foods, such as papaya, provide
humans with protection against inflammatory
polyarthritis, a form of rheumatoid arthritis
involving two or more joints.
d. Promote Lung Health
If you are smoker, or if you are frequently
exposed to second hand smoke. Eating vitamin A
rich foods, such as papaya, help your lung healthy
and save your life.
e. Anti-Sickling Activity
Current research proves that papaya is having an
anti-sickling activity
f. Prevent Prostate Cancer
Men consuming lycopene-rich fruits and
vegetables such as papaya, tomatoes, apricots,
pink grapefruit, watermelon, and guava were 82%
less likely to have prostate cancer compared to
those consuming the least lycopene-rich foods.
G. Anticoagulant Effect
Injection of papian extract in a dog increases
prothrombin and coagulation threefold. It is also
claimed that the enzyme eliminates necrotic
tissues in chronic wounds, burns and ulcers.
Papain is also of commercial importance in the
brewery industry, in the food industry and in the
textile industry.
6. Allergies and Side Effects
Papaya is frequently used as a hair conditioner,
but should be used in small amounts. Papaya
releases a latex fluid when not quite ripe, which
can cause irritation and provoke allergic reaction
in some people.
The latex concentration of unripe papayas is
speculated to cause uterine contractions, which
may lead to a miscarriage. Papaya seed extracts
in large doses have a contraceptive effect on rats
and monkeys, but in small doses have no effect
on the unborn animals.
Excessive consumption of papaya can cause
carotenemia, the yellowing of soles and palms,
which is otherwise harmless. However, a very
large dose would need to be consumed; papaya
contains about 6% of the level of beta carotene
found in carrots (the most common cause of
carotenemia)
a. Toxicity
Externally the papaya latex is an irritant to the
skin and internally it causes severe gastritis.
Some people are allergic to various parts of the
fruit and even the enzyme papain has its negative
properties.
b. Skin Discoloration
Eating too much of a yellow, green or orange-
colored food that contains beta carotene can
cause a benign form of skin discoloration called
carotenemia. The palms of the hands and soles of

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the feet are the most visible areas of the body
affected by carotenemia. Cutting back on your
papaya consumption will resolve the
discoloration of the skin.
c. Free Radical Scavenging Acivity
Papaya has many phenolic groups which may
scavange free radicals. Aqueous extract of papaya
leaves shows anti-oxidant activity
d. Respiratory Distress
Papain is also a potential allergen, according to
Purdue University, people who eat too much
papaya and ingest high levels of papain may
develop symptoms consistent with hay fever or
asthma, including wheezing, breathing difficulties
and nasal congestion.
e. Gastrointestinal Symptoms
Ironically, the same papain that calms your
stomach can cause an upset stomach when taken
in large amounts. The high fiber content of
papaya can also contribute to unrest of the
digestive system. The latex of the fruit's skin can
also cause irritation of the stomach.
7. Preliminary Research
Papaya seed extract may have in toxicity-induced
kidney failure. Evidently a kidney-transplant
patient in London was cured of a post-operative
infection by placing strips of papaya on the
wound for 48 hours. Women in India,
Bangladesh, Pakistan, Sri Lanka, and other
countries have long used green papaya as an
herbal medicine for contraception and abortion.
Enslaved women in the West Indies were noted
for consuming papaya to prevent pregnancies and
thus preventing their children from being born
into slavery.
Is Papaya in Pregnancy Safe or Not?
There are so many old wives tales and
information flooding the media that people
should or should not have certain foods to eat
during pregnancy. But there is one specific food
which I get asked about so regularly that I need to
write about it. That's Papaya, is it Safe?
There have been many research projects into the
effects of foods on pregnant women and papaya
is no exception. Now the problem with Papaya is
that in an unripe state the Papaya contains high
concentrations of Latex, this latex concentration
reduces upon ripening and once completely ripe
has almost no latex left.
The Papaya latex's main constituents are papain
and chymopapain which have teratogenic
(abnormalities of physiological development) and
abortifacient (Can induce an abortion) effects. It
does this by increasing the chances of uterine
contractions as the papain acts like prostaglandin
and oxytocin which are known to put a mother’s
body into labour and hence an adverse effect on
the babies and mothers health.
The Latex can also cause marked oedema and
haemorrhagic placentas which are bleeding and
hemorrhaging from the edge of the placenta, this
can result in severe complications in pregnancy
and normally an early delivery.
Table 3: Home remedies practices
Preparation
Uses
PEEL
Application of
peel with a
little milk and
honey
protects soothe and moisturize the skin
Apply peel as
the face mask
for about 20
minutes
quite effective in ridding the skin of
blemishe
Slice papaya
into small
pieces; soak in
vinegar for
several weeks.
Remove the
peel and
fights dandruff

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papaya
vinegar with
lemon juice
can be applied
to the scalp
for 20 minutes
prior to
shampooing
to fight
dandruff.
peel simmered
in olive oil,
almond oil
and rosehip
oil, and the
resulting
papaya oil
massaged into
the skin and
use with
honey and
rose water
Works as a skin toner and skin cleanser
Adding
papaya oil and
vinegar to
bath water,
with oils like
lavender,
orange and
rosemary
nourishing, refreshing and relaxing, and
can work as a pain reliever and muscle
relaxant
FRUITS
Eat Fresh
Ripe papaya
in the morning
Indigestion, constipation, flatulence,
improve appetite
Apply unripe
papaya juice
on affected
area.
pimples, eczema, mouth ulcer
Eat at least
200gm of ripe
fruit
Eliminate acid reflux.
Fruit
It is used to treat mouth ulcer, gum
disease and toothache.
Unripe fruit
Contraceptive in some Asian countries
Soup made
from fish and
nearly ripen
In Southern China, lactating mothers
drink the soup to improve milk flow
fruit
LEAVES
Wash the leaf
and cut into
smaller pieces
Squeeze the
pulp and filter
with the cloth
Two
tablespoons
serving per
day
It has a very
bitter taste.
Hence it may
provide some
relief to
dengue fever.
Can cure dengue fever.
Leaves
Dressing wounds and injuries
ROOTS
A decoction
formed by
boiling the
outer part of
the roots
Cure of dyspepsia.
SEEDS
Dried seeds
pounded and
mixed with
vinegar.
skin irritant to lower fever
Fresh or dry
crushed seeds
bacteriostatic, bactericidal and fungicidal.
Take half
Expel intestinal worms

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teaspoon
ground
papaya seed
with warm
water in the
morning
before
breakfast.
follow 2 hours
later with
50ml castor
oil and 350ml
milk on an
empty
stomach, take
this for 2-4
days
Seeds
Detoxify the liver
8. Cosmetic Benefits of Papaya
Rubbing the white pulp of raw papaya improves
pimples as well as wrinkles. Papaya works as a
good bleaching agent. It is an important
ingredient in bath soaps, astringents, detergent
bars and hand washes.Home Recipe for Papaya
Skin Lightner Experts suggest that papaya can
help in removing dead worn-out skin cells and
replace it with healthy new cells, thereby
lightening the color of our skin. For this, one can
prepare a paste of raw papaya and apply it on the
skin once for few days.
9. Conclusion:
Carica papaya is a neutraceutical plant having a
wide range of pharmacological activates. The
whole plant has its own medicinal value. The
wide range of enzymes, vitamins present in
Carica papaya makes it a neutraceutical plant.
The present review is about all the prominent
pharmacological activity, home remedies and side
effects of Carica papaya.
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