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Assesment the role of Dexamethasone on modulation of acute and chronic pain and compare with stress analgesic effect in formalin test in mice

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... On the other hand, our previous studies showed that Glucocorticoids and stress have analgesic effects (23, 24) and one of the mechanisms involved in these effects was opioidergic system (25). Besides, some previous studies suggested that there is probably an interaction between the antinociceptive effects of CS and the opioidergic system. ...
... Furthermore, our results showed that DEX (as an agonist of glucocorticoid receptor that released the hypophyseal endorphins and junction to receptors) and ST ( which activates the hypothalamus-pituitary-adrenal axis and causes a release in glucocorticoids) have analgesic effects which confirmed the results of the previous studies (23, 24, 40, 41). ...
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Our previous study showed that Coriandrum sativum (CS) has antinociceptive effects, but the mechanisms that mediate this effect are not clear. The present study was designed to test the role of opiate system in the antinociceptive effects of CS on acute and chronic pain in mice using Hot Plate (HP), Tail Flick (TF) and Formalin (FT) tests and also to compare its effect with dexamethasone (DEX) and stress (ST). Young adult male albino mice (25-30 g) in 33 groups (n = 8 in each group) were used in this study. CS (125 250, 500 and 1000 mg/Kg IP), DEX (0.5, 1 and 2 mg/Kg IP), vehicle (VEH) or swim stress were used 30 min before the pain evaluation tests. Acute and chronic pain was assessed by HP, TF and FT models. In addition, Naloxone (NAL, 2 mg/Kg, IP) was injected 15 min before the CS extract administration in order to assess the role of opiate system in the antinociception of CS. Results indicated that CS, DEX and ST have analgesic effects (p < 0.01) in comparison with the control group and higher dose of CS was more effective (p < 0.001). Besides, pretreatment of NAL modulates the antinociceptive effects of CS in all models (p < 0.001). The above findings showed that CS, DEX and ST have modulator effects on pain. These findings further indicate that the CS extract has more analgesic effects than DEX and ST and also provides the evidence for the existence of an interaction between antinociceptive effects of CS and opiate system.
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Objective: To determine and introduce medicinal plants used in the treatment of psychological disorders in Urmia city of Iran. Methods: Direct observation, interviews and collection of herbarium native medicinal herbs were used in this study. Questionnaires included herbalists ’ personal information, native herbs list to include local name of plant, used organ, application methods and therapeutic effect of the plant. Samples that listed in the questionnaires were collected to determine the genus and species. Results: By interviews, 22 medicinal plants of 10 families were determined in Urmia city. Asteraceae family had the most therapeutic effects (32%). Seeds of plants were the most used organs and common application method of plants was decoction (80%). Conclusions: Indigenous knowledge of medicinal plants offers new ideas for modern pharmaceutical science. These study results might be tested experimentally in order to produce new herbal remedies for management of neurological and psychiatric disorders.
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