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Clinical effects of fish type I collagen hydrolysate on skin properties

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... Collagens are the major group of structural proteins found in the extracellular matrix of all eukaryotic tissues (COOPER, 2007). The main source of collagen for biomedical and cosmetic use is based on bovine and porcine tissues, such as skin, tendon, cartilage, etc. Due to medical concerns and religious believes aquatic species, such as fishes and invertebrates were lately considered an alternative source of collagen for a variety of applications in several domains (MATSUMOTO, 2006). Over the last decade, aquatic species served to recover many bioactive compounds for regenerative medicine, collagen being the most common used biomaterial in tissue management due to its biocompatibility (BINSI, 2013). ...
... Several reports showed that cell proliferation and migration were promoted by peptides extracted from different species of marine fish. In vivo tests using fish type I collagen hydrolyzate (Amino collagen, Meiji Seika, Tokyo, Japan) taken orally showed an increase in the moisture content of the face cheek, the improvement of the viscoelasticity and a lower sebum content (MATSUMOTO, 2006). Peptides extracted from tuna back-bone, sardine muscle (SENEVIRATHNE, 2012) and bulk fish protein hydrolysates from defatted salmon backbones presented antioxidant properties (SLIZYTE, 2016), and also protein hydrolysates from cod muscle were found to contain growth factors or secretagogues (RAVALLEC, 2000). ...
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Fish bones mainly contain type I collagen and hydroxyapatite, and despite of their potential for applications in biotechnology and biomedicine, they represent one of the major source of waste generated by fish processing industry. The present study was focused on the interaction of bioactive peptides extracted from silver carp (H. molitrix) bones with human keratinocytes in culture. The potential of fish bone bioactive peptides to influence cell viability, proliferation and migration was evaluated in different experimental models in vitro. The results demonstrated a high efficiency and bioactivity of the enzymatically extracted fish bone peptides in several processes involved in cutaneous wound healing, in particular stimulation of keratinocytes metabolism and migration. In conclusion, they present a huge potential for applications in skin tissue engineering, but also in the biomedical and cosmetic fields.
... Additionally, evidence from the animal models suggested that oral administration of collagen reduces the intensity of skin hydration caused by UV radiation and also reduces hyperplasia of the epidermis caused by UV rays [36]. Furthermore, oral intake of collagen enhances the moisture content of the skin, especially the stratum corneum, as well as the elasticity of the skin, reducing wrinkling and roughness [37]. Overall, collagen causes an increase in fibroblasts and extracellular matrix proteins and a decrease in metalloproteinase. ...
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Introduction: Slowing the aging process by use of collagen supplements has become a driving force in the field of dermatology and cosmetics. Generally, oral and topical collagen are used in anti-aging products, as reported in the literature. Objectives: The overarching goal of this research is to collate the consequences of oral collagen with those of topical collagen in reducing or delaying the aging process. Methods: We executed an electronic search in Google Scholar and PubMed. We considered a study eligible if it was original research, published in English between 2010 and 2020, and if it provided information on the topic of collagen and aging. We retrieved 12 full-text articles, and these were assessed by reviewers independently. Results: All human studies included in the review were randomized controlled trials mainly conducted in high- to middle-income countries which highlighted that both oral and topical collagen supplements help to delay the aging process, with no differences arising between the two types of collagen. The evidence from the reviewed studies suggested that both collagen supplements improve skin moisture, elasticity, and hydration when orally administered. Additionally, collagen reduces the wrinkling and roughness of the skin, and existing studies have not found any side effects of its oral supplements. Conclusions: Both oral and topical collagen can contribute to reducing or delaying skin aging. Future epidemiological studies with large sample sizes and thorough follow-up measures would be required to comprehensively understand the potential effects of these two types of collagen on the aging process.
... Proliferation and cell migration with new extracellular matrix formation are a few of the steps involved in the wound healing process [144]. Oral administration of peptides extracted from various fish species and their by-products, such as collagen hydrolysates, demonstrates retention of moisture over the face along with enhanced viscoelastic properties and reduced sebum levels [145]. Enzymatic protein hydrolysates derived from the bones of silver carp and isolated peptides showed higher efficiency in stimulating metabolism of keratinocytes and wound healing activities, demonstrating the promising nature of bone peptides in care of wounds in the cutaneous region [146]. ...
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Developing peptide-based drugs are very promising to address many of the lifestyle mediated diseases which are prevalent in a major portion of the global population. As an alternative to synthetic peptide-based drugs, derived peptides from natural sources have gained a greater attention in the last two decades. Aquatic organisms including plants, fish and shellfish are known as a rich reservoir of parent protein molecules which can offer novel sequences of amino acids in pep-tides, having unique bio-functional properties upon hydrolyzing with proteases from different sources. However, rather than exploiting fish and shellfish stocks which are already under pressure due to overexploitation, the processing discards, regarded as secondary raw material, could be a potential choice for peptide based therapeutic development strategies. In this connection, we have attempted to review the scientific reports in this area of research that deal with some of the well-established bioactive properties, such as antihypertensive, anti-oxidative, anti-coagulative, antibac-terial and anticarcinogenic properties, with reference to the type of enzymes, substrate used, degree of particular bio-functionality, mechanism, and wherever possible, the active amino acid sequences in peptides. Many of the studies have been conducted on hydrolysate (crude mixture of peptides) enriched with low molecular bioactive peptides. In vitro and in vivo experiments on the potency of bioactive peptides to modulate the human physiological functions beneficially have demonstrated that these peptides can be used in the prevention and treatment of non-communicable lifestyle mediated diseases. The information synthesized under this review could serve as a point of reference to drive further research on and development of functionally active therapeutic natural peptides. Availability of such scientific information is expected to open up new zones of investigation for adding value to underutilized secondary raw materials, which in turn paves the way for sustainability in fish processing. However, there are significant challenges ahead in exploring the fish waste as a source of bioactive peptides, as it demands more studies on mechanisms and structure-function relationship understanding as well as clearance from regulatory and statutory bodies before reaching the end user in the form of supplement or therapeutics. Citation: Phadke, G.G.; Rathod, N.B.; Ozogul, F.; Elavarasan, K.; Karthikeyan, M.; Shin, K.-H.; Kim, S.-K. Exploiting of Secondary Raw Materials from Fish Processing Industry as a
... In other words, collagen peptides have a role in protecting against skin aging. In addition, clinical trials have shown that a 6-week intake of fish collagen peptides (FCP) improved skin hydration in female volunteers 34,35) . Kalil et al. reported in their clinical study that there were no side effects or systemic effects by FCP, and that the FCP-treated group showed not only better skin texture and hydration, but also improved brightness 36) . ...
Article
Fish collagen peptides (FCP) derived from the skin, bones and scales are commercially used as a functional food or dietary supplement for hypertension and diabetes. However, there is limited evidence on the effects of FCP on the osteoblast function in contrast to evidence of the effects on wound healing, diabetes and bone regeneration, which have been obtained from animal studies. In this narrative review, we expound on the availability of FCP by basic research using osteoblasts. Low-concentration FCP upregulates the expression of osteoblast proliferation, differentiation and collagen modifying enzyme-related genes. Furthermore, it could accelerate matrix mineralization. FCP may have potential utility as a biomaterial to improve collagen quality and promote mineralization through the mitogen-activated protein kinase and Smad cascades. However, there are few clinical studies on bone regeneration in human subjects. It is desirable to be applied clinically through clinical study as soon as possible, based on the results from basic research.
... The improved elasticity values mean higher distensibility of the elastin fibres. Our results are in agreement with previous investigations where oral administration of collagen-derived products have shown an improvement on skin elasticity [7,26]. Regarding skin fatigue, a significant decrease was observed in both treatments Ovoderm® and placebo, nevertheless, the decline in skin fatigue was greater in Ovoderm® group (33%) than in the placebo group (18%). ...
Article
Human skin physiology changes during the course of life involving age-related changes in skin appearance. It has been suggested that eggshell membrane, a natural ingredient containing collagen, hyaluronic acid, elastine, among others, can be used for improving skin. However, there are limited clinical studies using eggshell membrane as a dietary supplement to study skin health. The efficacy of Ovoderm®, an oral supplement from eggshell membrane, on skin biophysical parameters related to cutaneous aging was evaluated.
... Importantly, the collagen peptides reach the skin tissue and are able to remain there for several days [6]. Indeed, a number of clinical studies confirmed beneficial effects of hydrolyzed collagen on human skin [5], for instance by increasing skin elasticity and hydration [7][8][9][10][11][12]. ...
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Objective: Skin health, skin appearance and skin beauty are influenced by collagen composition of the dermis. Natural aging affects the structural integrity of the collagen network, resulting in drier skin, wrinkle formation and reduced skin elasticity. Orally ingested hydrolyzed collagen reaches the skin tissue and exerts beneficial effects on human skin from within. However, not only collagen peptides, but also micronutrients can beneficially affect skin appearance. Thus, dietary supplements for cosmetic and beauty effects containing combinations of collagen peptides and selected micronutrients are in demand. Aim of this study was to investigate the effect of a food supplement with collagen hydrolysate and micronutrients on skin beauty. The test product was assessed for its capability to reduce wrinkles and to improve skin hydration and collagen structure.
... Collagen peptides can also help our skin cape with some bad situation. Ingestion of collagen peptides improves the skin properties of women during winter (Matsumoto, 2006). The skin benefit effects are also found in the skin of pigs (Matsuda et al., 2006), mice (Pyun et al., 2012;Okawa et al., 2012) and others, with the phenomenon of increased fibroblast density. ...
... The benefits of daily ingestion of hydrolyzed collagen (10 g) on skin hydration of 20 healthy Japanese women compared to the placebo group (19 volunteers) were evaluated by Sumida et al. [15] In comparison with the placebo group, gradual improvement of water absorption capacity was observed through 60 days in volunteers who ingested collagen peptides. Matsumoto et al. [16] presented results of a trial also suggesting that a daily ingestion of collagen peptides improve skin hydration. The authors reported subjective improvement of the skin condition of woman's volunteers after ingestion of fish collagen peptides for 6 weeks. ...
... -08, 2008. With that, the content of collagen in a single serving of the product, i.e., 200 ml of the drink, should be 200 % of the daily need, which is 5 g (Matsumoto et al., 2006;Moskowitz, 2000). The content of dry matter in the ingredients of the starch drink formulation (FI) is shown in Table 1, and its nutritional value in Table 2. (1) Based on the information matrix (Table 1), Table 3 shows a system of linear balance equations and limitations. ...
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There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot and mouth diseases, has an economic and environmental benefits, and may be suitable for those that practice religious-based food restrictions, i.e., people of Muslim, Jewish and Hindu faiths. It has unique rheological properties, making it more suitable for certain applications than mammalian gelatins. It can be easily modified to enhance its mechanical properties. However, extensive research is still needed to characterize gelatin hydrolysates, elucidate the Structure Activity Relationship (SAR), and formulate them into dosage forms. Additionally, expansion into cosmetic applications and drug delivery is needed.
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