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Ejaculation Malfunctions on the Day of Oocyte Pick up for IVF/ICSI: A Report of Four Cases

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  • IVF World

Abstract

Introduction: The procedure of in-vitro fertilization (IVF) is sometime physically stressful and emotional turmoil on the couples undergoing treatment. The male partner is obliged to produce semen for injection/insemination with the oocytes. Unfortunately, some men are ill-fated, not capable to reproduce semen on the day of oocyte pickup. Objective: To testify four cases of unexpected ejaculation malfunction on the day of oocyte pickup. Setting: Base Fertility Medical Science Pvt Ltd. Materials and method: The case retrospectively reviewed the case records of four couples over a year period (September 2013–November 2014), who suffered unexpected ejaculation complete failure on the day of oocyte pickup for IVF/ICSI. Data, including age, Stimulation Protocol, cause(s) of infertility, previous treatment history (If Any) and various techniques implemented to retrieve sperms were documented. Results: Altogether, 362 oocyte pickup cycles were conducted during a year period. Four men had ejaculatory failure, providing an incidence factor of 1.10 %. Three cases (75%) had no earlier symptom/history of complexity in producing semen on requirement. Even Recommendation of 50 mg Vardenafil /Sildenafil citrate and the couples watching sexually stimulating videos did not remedy the situation. Surgical sperm retrieval was successful in case 1. It yielded no live sperm sample in case 2. Cases 3 and 4 had repeat IVF cycles. The male partners were not aware that oocyte retrieval would take place the next day and produced semen within a couple of hours. Conclusion: Anxiety and psychogenic stress most likely played a major role in these reported cases. Key: It is hoped that liquid nitrogen for cryopreservation would be the more readily available and easy technique to adopt in such scenarios to be followed for the centres for semen cryopreservation as a necessary prestep towards helping such couples and the upcoming techniques’ not widely in practice in developing countries ,oocyte vitrification*.
Ejaculation malfunctions on the day of oocyte pick up for IVF/ICSI:
A report of four cases
1Aamir Javed, 1Ashwini LS, 2Vijaya Geetha Pathangae, 2Ashim Roy,
3Debashree Ganguly
1Department of Embryology, Base Fertility Medical Science Pvt Ltd, India.
2R & D in Life Sciences, Dayananda Sagar Institutions, India.
3Jahar Infertility Research Institute, India
*Corresponding author: Javed Aamir, Department of Embryology, BFMS, KHB Colony,
Basaveshwarnagar, Bangalore – 79, India.
Email: javed.aamir7700@gmail.com
Keywords: Ejaculation malfunctions; IVF/ICSI
ABSTRACT
Introduction:
The procedure of in-vitro fertilization (IVF) is sometime physically stressful and emotional turmoil
on the couples undergoing treatment. The male partner is obliged to produce semen for
injection/insemination with the oocytes. Unfortunately, some men are ill-fated, not capable to
reproduce semen on the day of oocyte pickup.
Objective: To testify four cases of unexpected ejaculation malfunction on the day of oocyte pickup.
Setting: Base Fertility Medical Science Pvt Ltd.
Materials and method: The case retrospectively reviewed the case records of four couples over a
year period (September 2013–November 2014), who suffered unexpected ejaculation complete
failure on the day of oocyte pickup for IVF/ICSI. Data, including age, Stimulation Protocol,
cause(s) of infertility, previous treatment history (If Any) and various techniques implemented to
retrieve sperms were documented.
Results: Altogether, 362 oocyte pickup cycles were conducted during a year period. Four men had
ejaculatory failure, providing an incidence factor of 1.10 %. Three cases (75%) had no earlier
symptom/history of complexity in producing semen on requirement. Even Recommendation of 50
mg Vardenafil /Sildenafil citrate and the couples watching sexually stimulating videos did not
remedy the situation. Surgical sperm retrieval was successful in case 1. It yielded no live sperm
sample in case 2. Cases 3 and 4 had repeat IVF cycles. The male partners were not aware that
oocyte retrieval would take place the next day and produced semen within a couple of hours.
Conclusion: Anxiety and psychogenic stress most likely played a major role in these reported
cases.
Key: It is hoped that liquid nitrogen for cryopreservation would be the more readily available and
easy technique to adopt in such scenarios to be followed for the centres for semen cryopreservation
as a necessary prestep towards helping such couples and the upcoming techniques’ not widely in
practice in developing countries ,oocyte vitrification*.
Index Term: Semen Cryopreservation, Ejaculation Malfunction, IVF, ICSI & Stimulants.
International Letters of Natural Sciences Vol. 48 (2015) pp 32-36 Online: 2015-11-03
© (2015) SciPress Ltd., Switzerland
doi:10.18052/www.scipress.com/ILNS.48.32
SciPress applies the Creative Commons Attribution license to works we publish: http://www.scipress.com/Home/OpenAccess
1. INTRODUCTION
The procedure of in vitro fertilization (IVF) can be actually stressful on the couples
undergoing treatment emotionally and physically. In our Assisted Reproductive Unit, averages of
350+* oocyte retrievals for IVF/ICSI are performed round the year. An ejaculation failure
incidence of 1.10% on the day of oocyte retrieval has occurred between September 2013 to
November 2014. Despite of the fact that the female partner is engaged with every day injections,
sequential ultrasound scans for the process of oocyte retrieval and successively embryo transfer,
however the male partner is called to produce semen for injection/ insemination to the oocytes
retrieved (1). Alas, some men are not able to perform out this chore when it doubtless matter most.
This is typically an exceptional occurrence with few incidences reports in the literature but for the
few to whom it occurs, it can be shattering and upsetting (2).Causes of ejaculation failure in general
include the first and foremost reason is the psychological disturbances and nervousness, use of
antipsychotics and antidepressant drugs, alcohol, excessive smoking and alcohol drinking (3).There
are numerous recommended ways of sperm retrieval for IVF/ICSI in such reported cases (4, 5).
These include (a) Oral prescription of 50 mg of Vardenafil and sildenafil citrate after an hour of
attempted sperm collection (b) Vibrostimulation (c) Vigorous prostatic massage (d)
Electroejaculation (e) Percutaneous epididermal sperm aspiration (PESA) ; (f) Testicular sperm
aspiration (TESA) ; (g) Testicular sperm extraction (TESE) ; (h) Microsurgical Eppidymal Sperm
aspiration (MESA) ; and (i) Sex therapy. At last if these attempts fail the last course of action is the
use of donor sperm. If a dilemma is diagnosed, the possibility of cryopreserving sperm for back-up
use is always better and carried out prior to initiating the treatment cycle. Here we discussed the
four case of ejaculation failure.
Case 1
Mr. AA was a 44-year serviceman married to a 36 year woman. Their only child was
conceived via IVF in 2010. Couple underwent subsequent ICSI cycles were unproductive and futile.
However there was no complexly in producing semen during the preceding cycles. Mr AA was
asked to go over again for his semen analysis at our unit but he refused as he felt he had done it
quite a lot of times in the times of yore and was absolutely normal. His wife had endometriosis and
bilaterally blocked tubes. The couple received pre-IVF counselling and commenced treatment in
October 2013. Six oocytes were retrieved on the day of oocyte retrieval Mr. AA was unable to
produce semen after 4 hour of continuous trying. He attempted masturbation and electro ejaculation
and later coitus with his partner with the use of a condom. A 100 mg dose of Sildenafil citrate was
prescribed and the clinic staffs calms his restlessness. After 4h.30m hour, PESA was successfully
performed without the local anaesthesia. Following Intracytoplasmic sperm injection (ICSI), three
reduced quality embryos were developed and transferred three days after oocyte retrieval. Which
post 15 days appeared us as a negative Beta-Hcg which did not result in a pregnancy.
Case 2
Mr. AB, was a 39-year IT professional married to a 40- year housewife. They had been
married for 15 years with no conception. A previous IVF cycle done in 2010 was unproductive.
There was an impediment in sperm production of about 6.00 h in that particular cycle. Mr. AB.
nevertheless had no difficulty with semen production for the analysis. He had normal semen count
and parameters. No particular reason was found for the couple’s infertility quandary. They had pre-
IVF counselling in particular on the near to the ground success rate using the wife’s own eggs as the
age and AMH was a critical factor. They opted and preferred to go to the fore using their self eggs.
They commenced treatment in December 2013. Eleven oocytes were retrieved. Mr. AB was unable
to produce semen for 4.30 h regardless of watching sexually thought-provoking videos. His anxiety
was put to rest and 50 mg Sildenafil citrate was prescribed. He appealed to depart the clinic milieu
and produce semen from his residence, a short distance from the clinic. His request was accepted
but finally no procurement of sperms. After another 5.30 h, PESA subsequently TESA were
attempted, respectively under local anaesthesia, combined with intravenous promethazine and
International Letters of Natural Sciences Vol. 48 33
pentazocine regrettably, no live sperm cell was recovered and the cycle was futile. They had a
repeat cycle six months after, at a standstill preferring to use their own eggs. His semen sample was
cryopreserved for this particular cycle as a backup. On the day of oocyte pickup, he still could not
produce semen and the frozen sample was employed. Subsequently day 3 transfer of three Grade A
embryos, pregnancy occurred.
Case 3
Mr. AC was a 42-year Govt servant married to a 36-year house wife. She prior had a kid from
a different spouse before her present marriage. Her husband parallel had two children from an
earlier marriage. They had been unable to achieve a pregnancy after 10 years of nuptials. Mr.AC
had no problem with semen production for analysis and his sperm count was 30 million cells/ml
they had pre-IVF counselling and have the same opinion to use donor oocytes. Following IVF
treatment in Jan 2014, twelve oocytes were retrieved from the donor. Mr. AC could not produce
semen after 3 h of struggle with the aid of sexually provoking videos. Sildenafil citrate, 50 mg was
prescribed, his anxiety allayed and he had coitus interrupt us with his wife. Semen sample could
still not be reproduced. He refused any surgical procedure and the cycle was cancelled. They had a
repeat cycle in March 2014. The husband was not agreeable with the employ of cryopreserved
sperms, as he was not convinced it would result in a ‘‘normal baby’’. In conformity with the wife, a
pronouncement was taken to get the husband to produce semen a day previous to oocyte pickup
while informing him it was to be for future use. Mr. AC. succeeded in producing semen within an
hour. Following ICSI of five oocytes, three Grade A embryos were transferred on day 2. Pregnancy
test taken two weeks later was positive. A twin baby delivered.
Case 4
Mr. AD was a 32-year businessman, married to a 28-year housewife. She had 1 previous
premarital terminations of pregnancy .They had been unable to accomplish a pregnancy after one
year unprotected intercourse of marriage. Mr. AD produced semen without difficulty for analysis.
Semen parameters were usual and normal. Pre-IVF counselling was offered to the couple, but
refused. They commenced IVF treatment in October 2013. Seven metaphase 2 oocytes were
procured. Mr. AD could not produce semen after 4 h. He was reassured and given 50 mg of viagra,
which he disallowed. He opted to go his address and produce semen and assured to be back within
an hour. He was advised to bring the semen sample within half an hour of collection and asked to
inform back to the clinic if he still experience complication. After another 4 h, efforts were made at
reaching the couple but they had switched off their contact numbers. The cycle was eventually
cancelled by the end of that day. A repeat cycle was carried out four months later. They accepted
pre-IVF counselling because of the previous experience, this cycle semen cryopreservation was
accepted done at time, Mr. AD was not informed that the wife had commenced controlled ovarian
hyperstimulation. He produced semen within an hour, which was inseminated with his wife’s
oocytes. No pregnancy resulted.
2. DISCUSSION AND CONCLUSION
Four cases of unexpected ejaculation malfunction occurred during the 1-year period at our
assisted reproduction centre. A total of 362 oocyte pickup cycles were carried out during the period,
given an incidence of 1.11%. This is to a certain extent high report as we consider from other
centres divulge it is a very rare occurrence (6,7). However Emery et al described only five cases
over a 4 year period with an average oocyte retrieval cycle of 500 per year (7).The raison d'être for
our high prevalence may not be unbelievable. Contrasting in the Western developed world,
parenthood appears to have more and arguably, profound roots in Indian hamlet (8,9). In the typical
Indian society, children secure conjugal ties, offer social security, assist with labour, confer social
prominence secure rights of assets and inheritance, endow with continuity through re-incarnation
and maintaining the family lineage and satisfy emotional needs (8). Case 1 had no prior history of
ejaculation failure as he had no problems in producing semen on demand in the clinic during his
34 Volume 48
previous IVF attempts. While case 2 had a six hour interruption prior to producing semen in a
preceding IVF cycle, he had no malfunctions with semen production on requirement in the assisted
reproduction centre for analysis, just like cases 3 and 4. This shows that acute ejaculation failure
can transpire in patients who prior had no difficulty with semen production on request in the clinic.
Sildenafil citrate (Viagra) has been recommended at different dose after unsuccessful trials of more
than 2h to produce semen (10). At the same time as this has been successfully used in a few of our
patients, it did not yield the desired effect in the three cases in which it was prescribed earlier.
Surgical sperm procurement in the form of PESA and TESA have equally being used in such cases
to gain spermatozoa (11,12). While PESA was successfully done in case 1, both TESA and PESA
were unsuccessful in retrieving any live sperm in case 2. Case 3 refused any surgical procedure.
However for the next procedure semen was cryopreserved and pregnancy occurred earlier which he
denied as he believed cryopreserved semen will not result in a normal child. It is our standard
practice to counsel the couples to abstain from sexual intercourse for 3–4 days prior to oocyte
pickup. In all the cases psychogenic anejaculation on the day of oocyte retrieval played a vital role.
Anxiety has been shown in infertile couples to be the vast psychological manifestation, allied to the
stressful nature of IVF and the apprehension of failure (13).This is doubtless more manifested on
the day of oocyte retrieval. Therefore the case 4 have not been updated of the exact day or time of
oocyte retrieval that might have allayed their anxiety. Saleh and colleagues (14) collected data from
405 men with normal sexual function. All of them obtained a first semen sample devoid of
difficulty. After being notified that the analysis of their semen sample was abnormal, 11% (46/405)
failed to get hold of sperm by masturbation two weeks later. This psychogenic sexual dysfunction
followed severe anxiety, which increased in such men. There is however ethical dilemma involved
in this practice which most likely would not be suitable in industrialized countries. While the
equipments needed for cryopreservation of semen is much cheaper contrast to the equipments
required for IVF, availability and sustainability of liquid nitrogen is often times a luxury in our
environment. The women are usually stigmatized, leading to seclusion, neglect, domestic
aggression or they may end up as second wives in a polygamous marriage, while the husbands
might be denied their rightful legacy (15,16,17). When all the possible modus operandi of obtaining
sperm fails, the existing options would be to use donor sperms or cancel the treatment and
cryopreserve sperms for use in subsequent cycle. In our assisted reproduction centre, we frequently
will not use donor sperms except this had been discussed and agreed upon much prior with the
couples. In conclusion, although ejaculation failure on the day of oocyte retrieval is an atypical
incidence, it is a foremost cause for apprehension in our practice. Anxiety most likely played a vital
role in these stated cases. Even though there are ethical dilemmas, not divulging the definite date of
oocyte retrieval to the male partner believing at risk of unexpected ejaculation failure might be
correlated with reduced anxiety and therefore aid semen production. It is on the other hand hoped
that liquid nitrogen for cryopreservation would become more readily accessible in India so that
more centres can implement and adopt semen cryopreservation as an essential step towards
assisting such couples.
Acknowledgements
Express gratitude to Dr T S Muralidhar, our colleagues for the clinical data compilation for all of
their work toward the study, data collection and review.
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36 Volume 48
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Ejaculation Malfunctions on the Day of Oocyte Pick up for IVF/ICSI: A Report of Four Cases
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... Suelen señalarlo como un acto innecesariamente público y sórdido 22 , y es la principal causa referida de inasistencia a las revisiones seminales postvasectomía (48%) 21,23 . La incapacidad para eyacular cuando se les solicita es la expresión extrema de tales problemas; aunque es algo que parece alcanzar a un número limitado de adultos (1-2%) 24,25 , y de adolescentes (14%) 26 . Que sea más frecuente entre adolescentes muestra la influencia que ejerce la vergüenza durante el desempeño del POMSM. ...
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The quality of infertility care is dependent upon adequate material resources and the appropriate use of it. In addition, a mutual understanding between physicians and patients is necessary. These imperatives are more salient in the era of the new reproductive technologies. However, in poor-resource areas these imperatives are insufficiently met. Moreover, in developing countries the negative consequences of childlessness are much stronger than in Western societies. Until recently, the problem of infertility in Third World countries has received little public attention. A plea is made for a stronger policy interest in Third World infertility care. In this it is important to focus on prevention, appropriate diagnosis and treatment at primary and secondary health-care level and to take the existing cultural beliefs into account.
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To study psychosexual problems in men undergoing infertility evaluation. A cohort observational study. Male infertility diagnostic center. Four hundred twelve men undergoing infertility evaluation between 1999 and 2001. Baseline and follow-up data on sexual functions. Semen analysis for samples collected by masturbation. A second analysis was requested in 2 weeks upon finding an abnormality of semen parameters. Penile vibratory stimulation to help men who failed to collect semen on their second or subsequent appointments. Sexual functions (erection and orgasm) during the time of infertility evaluation. Seven of 412 men were excluded from the analysis due to a past history of sexual dysfunction. Of the remaining 405 men, 46 (11%) failed to collect semen by masturbation for a second semen analysis after repeated (2-4 times) attempts at 2- to 3-day intervals. Nine of these men (20%) were able to collect semen using vibratory stimulation. All 46 men experienced problems with erection or orgasm and had severe anxiety during attempts to masturbate and during sexual contact with their partners. Our study indicates that some men may experience sexual dysfunction of a psychogenic nature in response to the diagnosis of infertility.