A rapid specific UPLC method has been developed for simultaneous determination of Telmisartan (TS) impurities and Chlorthalidone (CT) impurities in their formulations. Chromatographic separation of these two compounds impurities was carried out an Acquity BEH Shield-RP18, 100 x 2.1 mm, 1.7 μm column is used for development of method pH 4.5 buffer is prepared using 0.025M Potassium dihydrogen phosphate, 0.0027M 1-hexane sulphonic acid sodium salt and 1 mL of triethyl amine in milli-Q water, pH 4.5 ± 0.05 adjusted with diluted ortho phosphoric acid. The mobile phase A consists pH 4.5 buffer & acetonitrile in the ratio 90:10 (v/v). Mobile phase B consists pH 4.5 buffers & acetonitrile in the ratio 20:80 (v/v). The flow rate of mobile phase is 0.3 mL/min with a gradient elution. The column temperature is 25°C and detection wavelength is 290 nm. The injection volume is 3 μL. The gradient program is as follows: time (min)/% mobile phase B: 0/20, 2/30, 5/45, 8/55, 10/80, 14/80, 14.1/20 and 18/20. The developed RPUPLC method was validated with respect to specificity, linearity, accuracy, precision, robustness and high sensitivity with detection limits and quantification limits. To the best of our knowledge, a rapid LC method, which separates all the impurities of Telmisartan and Chlorthalidone, disclosed in this investigation was not published elsewhere.