Conference Paper


To read the full-text of this research, you can request a copy directly from the authors.


Immediately after a radiologist dispersion event or nuclear disaster, a method is needed to quickly assay a large number of people for internal contamination. While no such method exists presently, we propose to adapt a Nuclear Medicine Gamma Camera and use internal dosimetric calculations to enable the high-throughput screening of urine bioassay samples. We determined the efficacy of using a nuclear medicine camera for high throughput bioassay screening and determined the minimum detectable concentrations (MDC) of radioactive material F-18 (511 keV) and Tc-99m (140 keV) that can be detected with our methodology. For this investigation, contribution from background radiation was determined and statistically compared against our signal to determine the MDC, the energy response of the Gamma Camera determined, and the effect of sample volume on detector efficiency determined. Our MDCs next were compared against the Protective Action Guidelines (PAGs) recommended by the Environmental Protection Agency. After the MDCs for various isotopes were calculated, the resulting radiation dose equivalent (mSv) were calculated from these potential intakes. Plain tap water was used to simulate human urine because of their approximately identical physical densities, and Tc- 99m and F-18 were the radioactive isotopes tested. The samples were imaged and counted with a Symbian Dual Head SPECT/CT and a desktop computer installed with E.SOFTVA25A; version at Brigham and Women’s Hospital. This technique demonstrated the ability to measure 35 samples in 10 min (approximately 1,600 samples in 8 h), which makes it the fastest technique available presently for large-scale screening bioassay. Our results also demonstrate that this technique will achieve MDCs 10% below the levels recommended by the EPA PAGs.

No full-text available

Request Full-text Paper PDF

To read the full-text of this research,
you can request a copy directly from the authors.

ResearchGate has not been able to resolve any citations for this publication.
ResearchGate has not been able to resolve any references for this publication.