Background. The usefulness of musicotherapy in the management of acute or chronicpain was recognized in the 1960, being used in dentistry, obstetrics, pre- and post-operative care, cancerology ⋯ There has been little work devoted to its use in rheumatology patients. Music induced an number of interactive factors which activate the endogenous system and modulate pain. We conducted a preliminary open study to demonstrate the feasibility of musicotherapy and evaluate its therapeutic efficacy. Methods. Musicotherapy sessions were organized within the hospital unit. The patients rested in the supine position, eyes closed, in a calm room with minimal lighting for 20-minute sessions twice a week. The music was diffused in a headset and adapted to the patient's tastes. Each session was composed of several phases progressively reaching a soo thing phase of relaxation followed by a progressive re-dynamizing phase (U-shaped curve). The patients scored their level of pain, physical (muscular) tension, and anxiety on three visual analog scales before and after each session. Forty patients with musculoskeletal pain participated in the musicotherapy sessions. Results. Mean pain level before the sessions was 5.16 points on the 10-point scale. After the musicotherapy sessions, the mean pain level was 3.34/10 (p<0.01, Student's t test for paired series). Physical tension fell from 5.06/10 before the sessions to 2.61/10 after the sessions (p<0.01) and anxiety from 4, 46110 before the sessions to 2.30/10 after the sessions (p<0.001), These three improvements were not correlated with age, gender, occupation, nationality, or type of disease. There was a trend towards a correlation between improvement in pain score and prior duration of pain (Pearson's coefficient = 0.313). Discussion, Tolerance to the musicotherapy sessions was excellent. The patients stated they were highly satisfied and had achieved substantial improvement in their perception of pain, physical tension, and anxiety. This therapeutic technique appears to be more effective on older chronic pain than on acute recent pain. Conclusion. Musicotherapy, applied for patients with pain, has enabled improvement in 88% of them. Musicotherapy appears to be another method to achieve relaxation. A controlled trial is being conducted for validation.