World Health Organization recognizes that atherosclerosis is the biggest epidemics in the world, because its clinical manifestations related with ischemic cardiopathy and cardiovascular and cerebrovascular diseases are the first cause of death and disability. Among the risk factors associated to this pathology are Diabetes Mellitus type II, arterial hypertension, obesity, hypercholesterinemia, ... [Show full abstract] tobacco use and others. Literature on the association to buccal diseases is scarcely, and refers only to deficient buccal hygiene. We present the case of a 52 years old patient referring he had suffered atherosclerosis events, with oral clinical manifestations consistent with periodontal recession and added gingival inflammation, gingival bleeding when exploring, and masticatory discomforts. Hypercolored gums, with increased volume, altered shape, consistence and texture, grade II dental mobility in lower teeth, 4-5 mm periodontal cavities. The microbiological analysis showed the existence of high levels of periodontal pathogens. It is appreciated the association between atherosclerosis physiopathologic elements, common risk factors with the periodontal disease and its expression in the buccal cavity as much in the gingival sulcus microbial flora as in the periodontal tissues.